Peringatan Keamanan

Most adverse reactions are related to the intravenous administration such as local irritation, pain, and hematoma. Extravasation can also be an issue.

Polidocanol

DB06811

small molecule approved

Deskripsi

Polidocanol is a sclerosing agent indicated to treat uncomplicated spider veins (varicose veins ?1 mm in diameter) and uncomplicated reticular veins (varicose veins 1 to 3 mm in diameter) in the lower extremity. It is marketed under the brand names Asclera and Varithena. The formula for Polidocanol has the structural formula C12H25(OCH2CH2)nOH, a mean extent of polymerization (n) of approximately 9 and a mean molecular weight of approximately 600.

Struktur Molekul 2D

Berat 582.8073
Wujud liquid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half-life is approximately 1.5 h.
Volume Distribusi When given intravenously, the volume of distribution was 35-82L.
Klirens (Clearance) Sytemic clearance was 0.2-0.4 L/min.

Absorpsi

When given intravenously, the maximum blood concentrations were reached in 15 mins.

Metabolisme

Metabolism was not measured.

Rute Eliminasi

Route of elimination was not indicated.

Interaksi Obat

36 Data
Peginterferon alfa-2a The therapeutic efficacy of Polidocanol can be decreased when used in combination with Peginterferon alfa-2a.
Pegfilgrastim The therapeutic efficacy of Polidocanol can be decreased when used in combination with Pegfilgrastim.
Peginterferon alfa-2b The therapeutic efficacy of Polidocanol can be decreased when used in combination with Peginterferon alfa-2b.
Pegaspargase The therapeutic efficacy of Polidocanol can be decreased when used in combination with Pegaspargase.
Pegademase The therapeutic efficacy of Polidocanol can be decreased when used in combination with Pegademase.
Pegvisomant The therapeutic efficacy of Polidocanol can be decreased when used in combination with Pegvisomant.
Propylene glycol The therapeutic efficacy of Polidocanol can be decreased when used in combination with Propylene glycol.
Heptaethylene glycol The therapeutic efficacy of Polidocanol can be decreased when used in combination with Heptaethylene glycol.
Pegaptanib The therapeutic efficacy of Polidocanol can be decreased when used in combination with Pegaptanib.
Egaptivon pegol The therapeutic efficacy of Polidocanol can be decreased when used in combination with Egaptivon pegol.
PEG-uricase The therapeutic efficacy of Polidocanol can be decreased when used in combination with PEG-uricase.
Peginterferon alfacon-1 The therapeutic efficacy of Polidocanol can be decreased when used in combination with Peginterferon alfacon-1.
GlycoPEG-GCSF The therapeutic efficacy of Polidocanol can be decreased when used in combination with GlycoPEG-GCSF.
Pegnivacogin The therapeutic efficacy of Polidocanol can be decreased when used in combination with Pegnivacogin.
Pegpleranib The therapeutic efficacy of Polidocanol can be decreased when used in combination with Pegpleranib.
Pegsunercept The therapeutic efficacy of Polidocanol can be decreased when used in combination with Pegsunercept.
Peginesatide The therapeutic efficacy of Peginesatide can be decreased when used in combination with Polidocanol.
Certolizumab pegol The therapeutic efficacy of Certolizumab pegol can be decreased when used in combination with Polidocanol.
Methoxy polyethylene glycol-epoetin beta The therapeutic efficacy of Methoxy polyethylene glycol-epoetin beta can be decreased when used in combination with Polidocanol.
Peginterferon beta-1a The therapeutic efficacy of Peginterferon beta-1a can be decreased when used in combination with Polidocanol.
Pegloticase The therapeutic efficacy of Pegloticase can be decreased when used in combination with Polidocanol.
Polyethylene glycol The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Polidocanol.
Antihemophilic factor (recombinant), PEGylated The therapeutic efficacy of Antihemophilic factor (recombinant), PEGylated can be decreased when used in combination with Polidocanol.
Insulin peglispro The therapeutic efficacy of Insulin peglispro can be decreased when used in combination with Polidocanol.
Eptacog alfa pegol (activated) The therapeutic efficacy of Eptacog alfa pegol (activated) can be decreased when used in combination with Polidocanol.
Olaptesed Pegol The therapeutic efficacy of Olaptesed Pegol can be decreased when used in combination with Polidocanol.
Abicipar Pegol The therapeutic efficacy of Abicipar Pegol can be decreased when used in combination with Polidocanol.
Lexaptepid pegol The therapeutic efficacy of Lexaptepid pegol can be decreased when used in combination with Polidocanol.
Cepeginterferon alfa-2B The therapeutic efficacy of Cepeginterferon alfa-2B can be decreased when used in combination with Polidocanol.
Pegvaliase The therapeutic efficacy of Pegvaliase can be decreased when used in combination with Polidocanol.
Pegamotecan The therapeutic efficacy of Pegamotecan can be decreased when used in combination with Polidocanol.
Lipegfilgrastim The therapeutic efficacy of Lipegfilgrastim can be decreased when used in combination with Polidocanol.
Nonacog beta pegol The therapeutic efficacy of Nonacog beta pegol can be decreased when used in combination with Polidocanol.
Damoctocog alfa pegol The therapeutic efficacy of Damoctocog alfa pegol can be decreased when used in combination with Polidocanol.
Elapegademase The therapeutic efficacy of Elapegademase can be decreased when used in combination with Polidocanol.
Rurioctocog alfa pegol The therapeutic efficacy of Rurioctocog alfa pegol can be decreased when used in combination with Polidocanol.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 22620717
    Peterson JD, Goldman MP, Weiss RA, Duffy DM, Fabi SG, Weiss MA, Guiha I: Treatment of reticular and telangiectatic leg veins: double-blind, prospective comparative trial of polidocanol and hypertonic saline. Dermatol Surg. 2012 Aug;38(8):1322-30. doi: 10.1111/j.1524-4725.2012.02422.x. Epub 2012 May 23.
  • PMID: 21605244
    Weiss RA, Voigts R, Howell DJ: Absence of concentration congruity in six compounded polidocanol samples obtained for leg sclerotherapy. Dermatol Surg. 2011 Jun;37(6):812-5. doi: 10.1111/j.1524-4725.2011.01906..x.
Link

Contoh Produk & Brand

Produk: 10 • International brands: 1
Produk
  • Asclera
    Injection, solution • 0.01000 g/1mL • Intravenous • US • Approved
  • Asclera
    Injection, solution • 0.00500 g/1mL • Intravenous • US • Approved
  • Asclera
    Injection, solution • 0.01000 g/1mL • Intravenous • US • Approved
  • Asclera
    Injection, solution • 0.00500 g/1mL • Intravenous • US • Approved
  • Varithena
    Injectable Foam; Kit • 10 mg/1mL • Intravenous • US • Approved
  • Varithena
    Injectable Foam; Kit • 10 mg/1mL • Intravenous • US • Approved
  • Varithena
    Injectable Foam; Kit • 10 mg/1mL • Intravenous • US • Approved
  • Varithena
    Injectable Foam; Kit • 10 mg/1mL • Intravenous • US • Approved
Menampilkan 8 dari 10 produk.
International Brands
  • Aethoxysklerol

Sekuens Gen/Protein (FASTA)

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