Peringatan Keamanan

Common adverse effects include headache, nausea and feeling of warmth or flushing. Other uncommon side effects include hypersensitivity reactions, fever, diarrhea, vomiting, dizziness, palpitations, paraesthesia, abdominal pain, and taste sensations. There is no identified antidote in case of overdose. Mangafodipir displays embryotoxic and fetotoxic potential thus is contradindicated in pregnant patients. It is not reported to be genotoxic L875. LD50 in the mouse is 5 mmol/kg A19718.

Mangafodipir

DB06796

small molecule approved investigational withdrawn

Deskripsi

Mangafodipir is a contrast agent used as a diagnostic tool administered intravenously to enhance contrast in magnetic resonance imaging (MRI) of the liver and pancreas. This drug is made up of paramagnetic manganese (II) ions combined with the chelating agent fodipir (dipyridoxyl diphosphate, DPDP). Manganese absorption into the tissues that makes the normal tissue appear brighter in MRI is limited in abnormal or cancerous tissue. Enhanced contrast by mangafodipir improves visualization and detection of lesions of the liver formed from metastatic disease or hepatocellular carcinomas. The contrast agent is present as mangafodipir trisodium marketed under the name Teslascan. Teslascan has been removed from the Drug Product List by FDA in 2003, and withdrawn from the European market in 2012.

Struktur Molekul 2D

Berat 691.382
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The mean initial plasma half-life of manganese metals is approximately 20 minutes and 50 minutes for fodipir (dipyridoxyl diphosphate, DPDP) [L874].
Volume Distribusi The volume of distribution for manganese is between 0.5 and 1.5 l/kg, and 0.17 to 0.45 l/kg for fodipir (dipyridoxyl diphosphate) [L874]. Fodipir is distributed rapidly throughout the body with the highest concentrations in the kidneys, lung, blood and liver with a low affinity in the myocardium and brain. Manganese is initially distributed to the kindeys and sequentially to liver, spleen and pancreas [L875].
Klirens (Clearance) The approximate total clearance of radiolabeled mangafodipir is 3.1 mL/min kg in dogs [A19709].

Absorpsi

Mangafodipir is taken up by the liver and pancreas where the contrast enhancement effect is mediated.

Metabolisme

Mangafodipir (MnDPDP) is dephosphorylated to form Mn dipyridoxyl monophosphate (MnDPMP) and fully dephosphorylated Mn dipyridoxyl ethylenediamine diacetate (MnPLED) in a sequential manner, followed by simultaneous transmetallation where maganese is exchanged for plasma zinc L874. Corresponsing zinc compounds are ZnDPDP, ZnDPMP and ZnPLED A19708. Manganese is released from the complex to be transported to target organs.

Rute Eliminasi

Fodipir is predominantly eliminated via urine within 24 hours where up to 25% of administered fodipir is excreted into feces. Manganese is mainly excreted into feces where renal elimination is about 15-20% of the dose L875.

Interaksi Obat

727 Data
Cyclosporine Cyclosporine may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Latamoxef Latamoxef may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Nimesulide Nimesulide may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Benoxaprofen Benoxaprofen may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Metamizole Metamizole may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Zomepirac Zomepirac may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Ceftobiprole Ceftobiprole may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Cimicoxib Cimicoxib may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Lornoxicam Lornoxicam may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Aceclofenac Aceclofenac may decrease the excretion rate of Mangafodipir which could result in a higher serum level.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 9571956
    Wang C: Mangafodipir trisodium (MnDPDP)-enhanced magnetic resonance imaging of the liver and pancreas. Acta Radiol Suppl. 1998;415:1-31.
  • PMID: 19834427
    Hirt D, Richardet JP, Urien S, Poupon J, Sogni P, Batteux F, Laurent A, Pavlovic S, Debray M, Treluyer JM, Weill B: Pharmacokinetic-pharmacodynamic modeling of manganese after a single intravenous infusion of mangafodipir in patients with acute alcoholic hepatitis. Ther Drug Monit. 2009 Oct;31(5):557-65. doi: 10.1097/FTD.0b013e3181affd6d.
  • PMID: 9245963
    Toft KG, Hustvedt SO, Grant D, Martinsen I, Gordon PB, Friisk GA, Korsmo AJ, Skotland T: Metabolism and pharmacokinetics of MnDPDP in man. Acta Radiol. 1997 Jul;38(4 Pt 2):677-89.
  • PMID: 9245964
    Hustvedt SO, Grant D, Southon TE, Zech K: Plasma pharmacokinetics, tissue distribution and excretion of MnDPDP in the rat and dog after intravenous administration. Acta Radiol. 1997 Jul;38(4 Pt 2):690-9.
  • PMID: 16570354
    Eser G, Karabacakoglu A, Karakose S, Eser C, Kayacetin E: Mangafodipir trisodium-enhanced magnetic resonance imaging for evaluation of pancreatic mass and mass-like lesions. World J Gastroenterol. 2006 Mar 14;12(10):1603-6.
  • PMID: 16941248
    Karabacakoglu A, Adiguzel Y, Karakose S, Kayacetin E, Haykir R: Characterization of focal liver lesions: use of mangafodipir trisodium (MnDPDP)-enhanced MR images. Turk J Gastroenterol. 2006 Sep;17(3):164-71.
  • PMID: 9626883
    Colet JM, Vander Elst L, Muller RN: Dynamic evaluation of the hepatic uptake and clearance of manganese-based MRI contrast agents: a 31P NMR study on the isolated and perfused rat liver. J Magn Reson Imaging. 1998 May-Jun;8(3):663-9.

Contoh Produk & Brand

Produk: 3 • International brands: 0
Produk
  • Teslascan
    Solution • 37.9 mg / mL • Intravenous • Canada • Approved
  • Teslascan
    Injection, solution • 0.01 mmol/ml • Intravenous • EU
  • Teslascan
    Injection, solution • 0.01 mmol/ml • Intravenous • EU

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