Levopropoxyphene

DB06793

small molecule withdrawn

Deskripsi

Levopropoxyphene is a stereoisomer of propoxyphene in the form of 2S, 3R enantiomer. It was sold as an antitussive, but it was removed from the market in the 70s.T133 Levopropoxyphene was developed by Lilly and FDA approved on March 21st, 1962. This drug presented different dosages and it was administered as a capsule or suspension.

Struktur Molekul 2D

Berat 339.479
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

90 Data
Pregabalin The therapeutic efficacy of Pregabalin can be decreased when used in combination with Levopropoxyphene.
Butalbital The therapeutic efficacy of Butalbital can be decreased when used in combination with Levopropoxyphene.
Phenytoin The therapeutic efficacy of Phenytoin can be decreased when used in combination with Levopropoxyphene.
Topiramate The therapeutic efficacy of Topiramate can be decreased when used in combination with Levopropoxyphene.
Pentobarbital The therapeutic efficacy of Pentobarbital can be decreased when used in combination with Levopropoxyphene.
Valproic acid The therapeutic efficacy of Valproic acid can be decreased when used in combination with Levopropoxyphene.
Trimethadione The therapeutic efficacy of Trimethadione can be decreased when used in combination with Levopropoxyphene.
Clobazam The therapeutic efficacy of Clobazam can be decreased when used in combination with Levopropoxyphene.
Secobarbital The therapeutic efficacy of Secobarbital can be decreased when used in combination with Levopropoxyphene.
Metharbital The therapeutic efficacy of Metharbital can be decreased when used in combination with Levopropoxyphene.
Methohexital The therapeutic efficacy of Methohexital can be decreased when used in combination with Levopropoxyphene.
Mephenytoin The therapeutic efficacy of Mephenytoin can be decreased when used in combination with Levopropoxyphene.
Lamotrigine The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Levopropoxyphene.
Carbamazepine The therapeutic efficacy of Carbamazepine can be decreased when used in combination with Levopropoxyphene.
Ethosuximide The therapeutic efficacy of Ethosuximide can be decreased when used in combination with Levopropoxyphene.
Thiopental The therapeutic efficacy of Thiopental can be decreased when used in combination with Levopropoxyphene.
Paramethadione The therapeutic efficacy of Paramethadione can be decreased when used in combination with Levopropoxyphene.
Clorazepic acid The therapeutic efficacy of Clorazepic acid can be decreased when used in combination with Levopropoxyphene.
Magnesium sulfate The therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Levopropoxyphene.
Tizanidine The therapeutic efficacy of Tizanidine can be decreased when used in combination with Levopropoxyphene.
Riluzole The therapeutic efficacy of Riluzole can be decreased when used in combination with Levopropoxyphene.
Ethotoin The therapeutic efficacy of Ethotoin can be decreased when used in combination with Levopropoxyphene.
Oxcarbazepine The therapeutic efficacy of Oxcarbazepine can be decreased when used in combination with Levopropoxyphene.
Primidone The therapeutic efficacy of Primidone can be decreased when used in combination with Levopropoxyphene.
Acetazolamide The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Levopropoxyphene.
Diazepam The therapeutic efficacy of Diazepam can be decreased when used in combination with Levopropoxyphene.
Phensuximide The therapeutic efficacy of Phensuximide can be decreased when used in combination with Levopropoxyphene.
Progabide The therapeutic efficacy of Progabide can be decreased when used in combination with Levopropoxyphene.
Methylphenobarbital The therapeutic efficacy of Methylphenobarbital can be decreased when used in combination with Levopropoxyphene.
Tiagabine The therapeutic efficacy of Tiagabine can be decreased when used in combination with Levopropoxyphene.
Zonisamide The therapeutic efficacy of Zonisamide can be decreased when used in combination with Levopropoxyphene.
Felbamate The therapeutic efficacy of Felbamate can be decreased when used in combination with Levopropoxyphene.
Zaleplon The therapeutic efficacy of Zaleplon can be decreased when used in combination with Levopropoxyphene.
Gabapentin The therapeutic efficacy of Gabapentin can be decreased when used in combination with Levopropoxyphene.
Clonazepam The therapeutic efficacy of Clonazepam can be decreased when used in combination with Levopropoxyphene.
Vigabatrin The therapeutic efficacy of Vigabatrin can be decreased when used in combination with Levopropoxyphene.
Phenacemide The therapeutic efficacy of Phenacemide can be decreased when used in combination with Levopropoxyphene.
Thiamylal The therapeutic efficacy of Thiamylal can be decreased when used in combination with Levopropoxyphene.
Phenobarbital The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Levopropoxyphene.
Levetiracetam The therapeutic efficacy of Levetiracetam can be decreased when used in combination with Levopropoxyphene.
Estazolam The therapeutic efficacy of Estazolam can be decreased when used in combination with Levopropoxyphene.
Fosphenytoin The therapeutic efficacy of Fosphenytoin can be decreased when used in combination with Levopropoxyphene.
Amobarbital The therapeutic efficacy of Amobarbital can be decreased when used in combination with Levopropoxyphene.
Hexobarbital The therapeutic efficacy of Hexobarbital can be decreased when used in combination with Levopropoxyphene.
Barbital The therapeutic efficacy of Barbital can be decreased when used in combination with Levopropoxyphene.
Delorazepam The therapeutic efficacy of Delorazepam can be decreased when used in combination with Levopropoxyphene.
Nitrazepam The therapeutic efficacy of Nitrazepam can be decreased when used in combination with Levopropoxyphene.
7-Nitroindazole The therapeutic efficacy of 7-Nitroindazole can be decreased when used in combination with Levopropoxyphene.
Valpromide The therapeutic efficacy of Valpromide can be decreased when used in combination with Levopropoxyphene.
Flunarizine The therapeutic efficacy of Flunarizine can be decreased when used in combination with Levopropoxyphene.
Ezogabine The therapeutic efficacy of Ezogabine can be decreased when used in combination with Levopropoxyphene.
Methsuximide The therapeutic efficacy of Methsuximide can be decreased when used in combination with Levopropoxyphene.
Brivaracetam The therapeutic efficacy of Brivaracetam can be decreased when used in combination with Levopropoxyphene.
Rufinamide The therapeutic efficacy of Rufinamide can be decreased when used in combination with Levopropoxyphene.
Lacosamide The therapeutic efficacy of Lacosamide can be decreased when used in combination with Levopropoxyphene.
Remacemide The therapeutic efficacy of Remacemide can be decreased when used in combination with Levopropoxyphene.
Clomethiazole The therapeutic efficacy of Clomethiazole can be decreased when used in combination with Levopropoxyphene.
Deramciclane The therapeutic efficacy of Deramciclane can be decreased when used in combination with Levopropoxyphene.
Tramiprosate The therapeutic efficacy of Tramiprosate can be decreased when used in combination with Levopropoxyphene.
Gaboxadol The therapeutic efficacy of Gaboxadol can be decreased when used in combination with Levopropoxyphene.
Sulthiame The therapeutic efficacy of Sulthiame can be decreased when used in combination with Levopropoxyphene.
Perampanel The therapeutic efficacy of Perampanel can be decreased when used in combination with Levopropoxyphene.
Ifenprodil The therapeutic efficacy of Ifenprodil can be decreased when used in combination with Levopropoxyphene.
Barbexaclone The therapeutic efficacy of Barbexaclone can be decreased when used in combination with Levopropoxyphene.
Beclamide The therapeutic efficacy of Beclamide can be decreased when used in combination with Levopropoxyphene.
Cannabidiol The therapeutic efficacy of Cannabidiol can be decreased when used in combination with Levopropoxyphene.
Paraldehyde The therapeutic efficacy of Paraldehyde can be decreased when used in combination with Levopropoxyphene.
Stiripentol The therapeutic efficacy of Stiripentol can be decreased when used in combination with Levopropoxyphene.
Eslicarbazepine acetate The therapeutic efficacy of Eslicarbazepine acetate can be decreased when used in combination with Levopropoxyphene.
Doramectin The therapeutic efficacy of Doramectin can be decreased when used in combination with Levopropoxyphene.
Tiletamine The therapeutic efficacy of Tiletamine can be decreased when used in combination with Levopropoxyphene.
Brexanolone The therapeutic efficacy of Brexanolone can be decreased when used in combination with Levopropoxyphene.
Etiracetam The therapeutic efficacy of Etiracetam can be decreased when used in combination with Levopropoxyphene.
Vinpocetine The therapeutic efficacy of Vinpocetine can be decreased when used in combination with Levopropoxyphene.
Carisbamate The therapeutic efficacy of Carisbamate can be decreased when used in combination with Levopropoxyphene.
Pheneturide The therapeutic efficacy of Pheneturide can be decreased when used in combination with Levopropoxyphene.
Neocitrullamon The therapeutic efficacy of Neocitrullamon can be decreased when used in combination with Levopropoxyphene.
Medazepam The therapeutic efficacy of Medazepam can be decreased when used in combination with Levopropoxyphene.
Phenibut The therapeutic efficacy of Phenibut can be decreased when used in combination with Levopropoxyphene.
Ethadione The therapeutic efficacy of Ethadione can be decreased when used in combination with Levopropoxyphene.
Cannabidivarin The therapeutic efficacy of Cannabidivarin can be decreased when used in combination with Levopropoxyphene.
Eslicarbazepine The therapeutic efficacy of Eslicarbazepine can be decreased when used in combination with Levopropoxyphene.
JNJ-26489112 The therapeutic efficacy of JNJ-26489112 can be decreased when used in combination with Levopropoxyphene.
Cenobamate The therapeutic efficacy of Cenobamate can be decreased when used in combination with Levopropoxyphene.
Amifampridine The risk or severity of seizure can be increased when Levopropoxyphene is combined with Amifampridine.
Dalfampridine The risk or severity of seizure can be increased when Levopropoxyphene is combined with Dalfampridine.
Bupropion The risk or severity of seizure can be increased when Bupropion is combined with Levopropoxyphene.
Fenfluramine The therapeutic efficacy of Fenfluramine can be decreased when used in combination with Levopropoxyphene.
Ganaxolone The therapeutic efficacy of Ganaxolone can be decreased when used in combination with Levopropoxyphene.
Hydroxychloroquine The risk or severity of seizure can be increased when Hydroxychloroquine is combined with Levopropoxyphene.

Target Protein

Mu-type opioid receptor OPRM1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 24671376
    Dicpinigaitis PV, Morice AH, Birring SS, McGarvey L, Smith JA, Canning BJ, Page CP: Antitussive drugs--past, present, and future. Pharmacol Rev. 2014 Mar 26;66(2):468-512. doi: 10.1124/pr.111.005116. Print 2014.
  • PMID: 12943851
    de Vries EJ, Janssen DB: Biocatalytic conversion of epoxides. Curr Opin Biotechnol. 2003 Aug;14(4):414-20.
Textbook
  • Tyrell J. (2014). Fundamentals of Industrial Chemistry. Wiley.

Contoh Produk & Brand

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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