Peringatan Keamanan

The symptoms associated with overdose are adverse reactions such as headache, nausea and vomiting. Lanthanum carbonate was not acutely toxic in animals by the oral route. No deaths and no adverse effects occurred in mice, rats or dogs after single oral doses of 2000 mg/kg.

Lanthanum carbonate

DB06792

small molecule approved

Deskripsi

Lanthanum carbonate is a phosphate binder marketed under the trade name Fosrenol by Shire Pharmaceuticals. It is a large pill that requires thorough chewing to avoid choking and other gastrointestinal adverse effects. It is used to treat elevated phosphate levels, primarily in patients with chronic kidney disease, by binding to dietary phosphate and preventing its absorption in the intestine.L50733

Struktur Molekul 2D

Berat 457.835
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The elimination half-life of lanthanum in patients undergoing dialysis was 53 hours following discontinuation of therapy.[L50733]
Volume Distribusi -
Klirens (Clearance) In healthy volunteers administered intravenous lanthanum as the soluble chloride salt (120 ?g), renal clearance was less than 2% of total plasma clearance.[L50733]

Absorpsi

The bioavailability of lanthanum carbonate following oral administration is exceedingly low (<0.002%), with a mean Cmax of 1.0 ng/mL and average serum concentration of 0.6 ng/mL.L50733 The timing of food intake relative to lanthanum administration (during and 30 minutes after food intake) has a negligible effect on the systemic level of lanthanum.L50733

Metabolisme

Lanthanum does not undergo metabolism.L50733

Rute Eliminasi

No information is available regarding the mass balance of lanthanum in humans after oral administration. In rats and dogs, the mean recovery of lanthanum after an oral dose was about 99% and 94%, respectively, and was essentially all from feces.L50733 Biliary excretion is the predominant route of elimination for circulating lanthanum in rats.L50733

Interaksi Makanan

1 Data
  • 1. Take with food.

Interaksi Obat

88 Data
Moxifloxacin Lanthanum carbonate can cause a decrease in the absorption of Moxifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Grepafloxacin Lanthanum carbonate can cause a decrease in the absorption of Grepafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enoxacin Lanthanum carbonate can cause a decrease in the absorption of Enoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pefloxacin Lanthanum carbonate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ciprofloxacin Lanthanum carbonate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Trovafloxacin Lanthanum carbonate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nalidixic acid Lanthanum carbonate can cause a decrease in the absorption of Nalidixic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rosoxacin Lanthanum carbonate can cause a decrease in the absorption of Rosoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cinoxacin Lanthanum carbonate can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lomefloxacin Lanthanum carbonate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gatifloxacin Lanthanum carbonate can cause a decrease in the absorption of Gatifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Norfloxacin Lanthanum carbonate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Levofloxacin Lanthanum carbonate can cause a decrease in the absorption of Levofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gemifloxacin Lanthanum carbonate can cause a decrease in the absorption of Gemifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ofloxacin Lanthanum carbonate can cause a decrease in the absorption of Ofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sparfloxacin Lanthanum carbonate can cause a decrease in the absorption of Sparfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Temafloxacin Lanthanum carbonate can cause a decrease in the absorption of Temafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fleroxacin Lanthanum carbonate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Technetium Tc-99m ciprofloxacin Lanthanum carbonate can cause a decrease in the absorption of Technetium Tc-99m ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Garenoxacin Lanthanum carbonate can cause a decrease in the absorption of Garenoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nemonoxacin Lanthanum carbonate can cause a decrease in the absorption of Nemonoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Flumequine Lanthanum carbonate can cause a decrease in the absorption of Flumequine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enrofloxacin Lanthanum carbonate can cause a decrease in the absorption of Enrofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Orbifloxacin Lanthanum carbonate can cause a decrease in the absorption of Orbifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sarafloxacin Lanthanum carbonate can cause a decrease in the absorption of Sarafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Difloxacin Lanthanum carbonate can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pazufloxacin Lanthanum carbonate can cause a decrease in the absorption of Pazufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Prulifloxacin Lanthanum carbonate can cause a decrease in the absorption of Prulifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Delafloxacin Lanthanum carbonate can cause a decrease in the absorption of Delafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sitafloxacin Lanthanum carbonate can cause a decrease in the absorption of Sitafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxolinic acid Lanthanum carbonate can cause a decrease in the absorption of Oxolinic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rufloxacin Lanthanum carbonate can cause a decrease in the absorption of Rufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pipemidic acid Lanthanum carbonate can cause a decrease in the absorption of Pipemidic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ampicillin The serum concentration of Ampicillin can be decreased when it is combined with Lanthanum carbonate.
Chloroquine Lanthanum carbonate can cause a decrease in the absorption of Chloroquine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Halofantrine Lanthanum carbonate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Doxycycline The serum concentration of Doxycycline can be decreased when it is combined with Lanthanum carbonate.
Lymecycline The serum concentration of Lymecycline can be decreased when it is combined with Lanthanum carbonate.
Clomocycline The serum concentration of Clomocycline can be decreased when it is combined with Lanthanum carbonate.
Oxytetracycline The serum concentration of Oxytetracycline can be decreased when it is combined with Lanthanum carbonate.
Demeclocycline The serum concentration of Demeclocycline can be decreased when it is combined with Lanthanum carbonate.
Tetracycline The serum concentration of Tetracycline can be decreased when it is combined with Lanthanum carbonate.
Metacycline The serum concentration of Metacycline can be decreased when it is combined with Lanthanum carbonate.
Minocycline The serum concentration of Minocycline can be decreased when it is combined with Lanthanum carbonate.
Sarecycline The serum concentration of Sarecycline can be decreased when it is combined with Lanthanum carbonate.
Omadacycline The serum concentration of Omadacycline can be decreased when it is combined with Lanthanum carbonate.
Penimepicycline The serum concentration of Penimepicycline can be decreased when it is combined with Lanthanum carbonate.
Ramipril Lanthanum carbonate can cause a decrease in the absorption of Ramipril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fosinopril Lanthanum carbonate can cause a decrease in the absorption of Fosinopril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Trandolapril Lanthanum carbonate can cause a decrease in the absorption of Trandolapril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Benazepril Lanthanum carbonate can cause a decrease in the absorption of Benazepril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enalapril Lanthanum carbonate can cause a decrease in the absorption of Enalapril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Moexipril Lanthanum carbonate can cause a decrease in the absorption of Moexipril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lisinopril Lanthanum carbonate can cause a decrease in the absorption of Lisinopril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Perindopril Lanthanum carbonate can cause a decrease in the absorption of Perindopril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Quinapril Lanthanum carbonate can cause a decrease in the absorption of Quinapril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Omapatrilat Lanthanum carbonate can cause a decrease in the absorption of Omapatrilat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rescinnamine Lanthanum carbonate can cause a decrease in the absorption of Rescinnamine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Captopril Lanthanum carbonate can cause a decrease in the absorption of Captopril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cilazapril Lanthanum carbonate can cause a decrease in the absorption of Cilazapril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Spirapril Lanthanum carbonate can cause a decrease in the absorption of Spirapril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Temocapril Lanthanum carbonate can cause a decrease in the absorption of Temocapril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Imidapril Lanthanum carbonate can cause a decrease in the absorption of Imidapril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zofenopril Lanthanum carbonate can cause a decrease in the absorption of Zofenopril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Delapril Lanthanum carbonate can cause a decrease in the absorption of Delapril resulting in a reduced serum concentration and potentially a decrease in efficacy.
Benazeprilat Lanthanum carbonate can cause a decrease in the absorption of Benazeprilat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fosinoprilat Lanthanum carbonate can cause a decrease in the absorption of Fosinoprilat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ramiprilat Lanthanum carbonate can cause a decrease in the absorption of Ramiprilat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Trandolaprilat Lanthanum carbonate can cause a decrease in the absorption of Trandolaprilat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Moexiprilat Lanthanum carbonate can cause a decrease in the absorption of Moexiprilat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Perindoprilat Lanthanum carbonate can cause a decrease in the absorption of Perindoprilat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Quinaprilat Lanthanum carbonate can cause a decrease in the absorption of Quinaprilat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cilazaprilat Lanthanum carbonate can cause a decrease in the absorption of Cilazaprilat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pravastatin The absorption of Pravastatin can be decreased when combined with Lanthanum carbonate.
Lovastatin The absorption of Lovastatin can be decreased when combined with Lanthanum carbonate.
Cerivastatin The absorption of Cerivastatin can be decreased when combined with Lanthanum carbonate.
Simvastatin The absorption of Simvastatin can be decreased when combined with Lanthanum carbonate.
Atorvastatin The absorption of Atorvastatin can be decreased when combined with Lanthanum carbonate.
Fluvastatin The absorption of Fluvastatin can be decreased when combined with Lanthanum carbonate.
Rosuvastatin The absorption of Rosuvastatin can be decreased when combined with Lanthanum carbonate.
Mevastatin The absorption of Mevastatin can be decreased when combined with Lanthanum carbonate.
Pitavastatin The absorption of Pitavastatin can be decreased when combined with Lanthanum carbonate.
Thyrotropin alfa Lanthanum carbonate can cause a decrease in the absorption of Thyrotropin alfa resulting in a reduced serum concentration and potentially a decrease in efficacy.
Liothyronine Lanthanum carbonate can cause a decrease in the absorption of Liothyronine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Levothyroxine Lanthanum carbonate can cause a decrease in the absorption of Levothyroxine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Liotrix Lanthanum carbonate can cause a decrease in the absorption of Liotrix resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tiratricol Lanthanum carbonate can cause a decrease in the absorption of Tiratricol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Thyroid, porcine Lanthanum carbonate can cause a decrease in the absorption of Thyroid, porcine resulting in a reduced serum concentration and potentially a decrease in efficacy.

Target Protein

Phosphate

Referensi & Sumber

Artikel (PubMed)
  • PMID: 36827665
    Nain P, Nayak N, Maj MC, Singh RK, Kaur J, Jeong Y, Maity S, Nath R, Hilgers RH, Nauhria S, Nauhria S: Efficacy of Lanthanum Carbonate and Sevelamer Carbonate as Phosphate Binders in Chronic Kidney Disease-A Comparative Clinical Study. Pharmacy (Basel). 2023 Feb 2;11(1):27. doi: 10.3390/pharmacy11010027.

Contoh Produk & Brand

Produk: 32 • International brands: 2
Produk
  • Fosrenol
    Tablet, chewable • 250 mg/1 • Oral • US • Approved
  • Fosrenol
    Tablet, chewable • 500 mg/1 • Oral • US • Approved
  • Fosrenol
    Tablet, chewable • 500 mg/1 • Oral • US • Approved
  • Fosrenol
    Tablet, chewable • 750 mg/1 • Oral • US • Approved
  • Fosrenol
    Tablet, chewable • 1000 mg/1 • Oral • US • Approved
  • Fosrenol
    Powder • 750 mg/1 • Oral • US • Approved
  • Fosrenol
    Powder • 1000 mg/1 • Oral • US • Approved
  • Fosrenol
    Tablet, chewable • 500 mg/1 • Oral • US • Approved
Menampilkan 8 dari 32 produk.
International Brands
  • Foznol
  • Phosbloc

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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