Injection site pain is the most common adverse effect associated with hydroxyprogesterone caproate. Other commonly reported adverse effects include: injection site swelling, urticaria, pruritus, injection site pruritus, nausea, injection site nodule, and diarrhea.
Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17?-hydroxyprogesterone formed from caproic acid (hexanoic acid). Hydroxyprogesterone caproate was previously marketed under the trade name Delalutin by Squibb, which was approved by the U.S. Food and Drug Administration (FDA) in 1956 and withdrawn from marketing in 1999.L46118 The U.S. FDA approved Makena from KV Pharmaceutical (previously named as Gestiva) on February 4, 2011 for prevention of preterm delivery in women with a history of preterm delivery, sparking a pricing controversy.
In April 2023, the FDA withdrew its approval of Makena and its generics given an unfavorable risk-to-benefit assessment.L46113
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Acitretin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Acitretin. |
| Atazanavir | The serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Atazanavir. |
| Boceprevir | The serum concentration of Hydroxyprogesterone caproate can be increased when it is combined with Boceprevir. |
| Exenatide | Exenatide can cause a decrease in the absorption of Hydroxyprogesterone caproate resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Sugammadex | The serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Sugammadex. |
| Thalidomide | Hydroxyprogesterone caproate may increase the thrombogenic activities of Thalidomide. |
| Ulipristal | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Ulipristal. |
| Tranexamic acid | Hydroxyprogesterone caproate may increase the thrombogenic activities of Tranexamic acid. |
| Clobazam | The serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Clobazam. |
| Colestipol | The serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Colestipol. |
| Sevelamer | The serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Sevelamer. |
| Colesevelam | The serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Colesevelam. |
| Cholestyramine | The serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Cholestyramine. |
| Griseofulvin | The metabolism of Hydroxyprogesterone caproate can be increased when combined with Griseofulvin. |
| Tixocortol | The serum concentration of Tixocortol can be increased when it is combined with Hydroxyprogesterone caproate. |
| Fluocortin | The serum concentration of Fluocortin can be increased when it is combined with Hydroxyprogesterone caproate. |
| Fluperolone | The serum concentration of Fluperolone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Fluclorolone | The serum concentration of Fluclorolone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Flunisolide | The serum concentration of Flunisolide can be increased when it is combined with Hydroxyprogesterone caproate. |
| Beclomethasone dipropionate | The serum concentration of Beclomethasone dipropionate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Betamethasone | The serum concentration of Betamethasone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Fluocinolone acetonide | The serum concentration of Fluocinolone acetonide can be increased when it is combined with Hydroxyprogesterone caproate. |
| Triamcinolone | The serum concentration of Triamcinolone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Prednisone | The serum concentration of Prednisone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Hydrocortisone | The serum concentration of Hydrocortisone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Prednisolone | The serum concentration of Prednisolone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Methylprednisolone | The serum concentration of Methylprednisolone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Corticotropin | The serum concentration of Corticotropin can be increased when it is combined with Hydroxyprogesterone caproate. |
| Cortisone acetate | The serum concentration of Cortisone acetate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Fluprednidene | The serum concentration of Fluprednidene can be increased when it is combined with Hydroxyprogesterone caproate. |
| Meprednisone | The serum concentration of Meprednisone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Dexamethasone isonicotinate | The serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Deflazacort | The serum concentration of Deflazacort can be increased when it is combined with Hydroxyprogesterone caproate. |
| Cortivazol | The serum concentration of Cortivazol can be increased when it is combined with Hydroxyprogesterone caproate. |
| Prednylidene | The serum concentration of Prednylidene can be increased when it is combined with Hydroxyprogesterone caproate. |
| Cloprednol | The serum concentration of Cloprednol can be increased when it is combined with Hydroxyprogesterone caproate. |
| Mometasone furoate | The serum concentration of Mometasone furoate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Hydrocortisone acetate | The serum concentration of Hydrocortisone acetate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Hydrocortisone succinate | The serum concentration of Hydrocortisone succinate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Prednisolone phosphate | The serum concentration of Prednisolone phosphate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Prednisolone hemisuccinate | The serum concentration of Prednisolone hemisuccinate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Methylprednisolone hemisuccinate | The serum concentration of Methylprednisolone hemisuccinate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Prednisone acetate | The serum concentration of Prednisone acetate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Clocortolone acetate | The serum concentration of Clocortolone acetate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Melengestrol acetate | The serum concentration of Melengestrol acetate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Betamethasone phosphate | The serum concentration of Betamethasone phosphate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Cortisone | The serum concentration of Cortisone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Fluticasone propionate | The serum concentration of Fluticasone propionate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Fluticasone furoate | The serum concentration of Fluticasone furoate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Fluticasone | The serum concentration of Fluticasone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Budesonide | The serum concentration of Budesonide can be increased when it is combined with Hydroxyprogesterone caproate. |
| Dexamethasone | The serum concentration of Dexamethasone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Paramethasone | The serum concentration of Paramethasone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Hydrocortisone cypionate | The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Fludrocortisone | The serum concentration of Fludrocortisone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Trilostane | The serum concentration of Trilostane can be increased when it is combined with Hydroxyprogesterone caproate. |
| Ciclesonide | The serum concentration of Ciclesonide can be increased when it is combined with Hydroxyprogesterone caproate. |
| Aldosterone | The serum concentration of Aldosterone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Fluprednisolone | The serum concentration of Fluprednisolone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Melengestrol | The serum concentration of Melengestrol can be increased when it is combined with Hydroxyprogesterone caproate. |
| Clobetasol propionate | The serum concentration of Clobetasol propionate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Fluocinonide | The serum concentration of Fluocinonide can be increased when it is combined with Hydroxyprogesterone caproate. |
| Hydrocortisone butyrate | The serum concentration of Hydrocortisone butyrate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Desoximetasone | The serum concentration of Desoximetasone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Mometasone | The serum concentration of Mometasone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Fluocortolone | The serum concentration of Fluocortolone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Prednisolone acetate | The serum concentration of Prednisolone acetate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Fluorometholone | The serum concentration of Fluorometholone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Difluocortolone | The serum concentration of Difluocortolone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Flumethasone | The serum concentration of Flumethasone can be increased when it is combined with Hydroxyprogesterone caproate. |
| Methylprednisolone aceponate | The serum concentration of Methylprednisolone aceponate can be increased when it is combined with Hydroxyprogesterone caproate. |
| Vitamin A | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Vitamin A. |
| Bexarotene | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Bexarotene. |
| Alitretinoin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Alitretinoin. |
| Tretinoin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Tretinoin. |
| Tazarotene | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Tazarotene. |
| Etretinate | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Etretinate. |
| Isotretinoin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Isotretinoin. |
| 4-Oxoretinol | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with 4-Oxoretinol. |
| Fenretinide | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Fenretinide. |
| Ro 12-7310 | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Ro 12-7310. |
| Zuretinol acetate | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Zuretinol acetate. |
| Motretinide | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Motretinide. |
| Bosentan | The serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Bosentan. |
| Carbamazepine | The serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Carbamazepine. |
| Piperacillin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Piperacillin. |
| Ampicillin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Ampicillin. |
| Phenoxymethylpenicillin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Phenoxymethylpenicillin. |
| Carbenicillin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Carbenicillin. |
| Oxacillin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Oxacillin. |
| Hetacillin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Hetacillin. |
| Benzylpenicilloyl polylysine | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Benzylpenicilloyl polylysine. |
| Mezlocillin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Mezlocillin. |
| Cyclacillin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Cyclacillin. |
| Benzylpenicillin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Benzylpenicillin. |
| Amoxicillin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Amoxicillin. |
| Azlocillin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Azlocillin. |
| Cloxacillin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Cloxacillin. |
| Amdinocillin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Amdinocillin. |
| Bacampicillin | The therapeutic efficacy of Hydroxyprogesterone caproate can be decreased when used in combination with Bacampicillin. |