The intramuscular LD50 in rats is approximately 105 mg/kg; intraperitoneally 140 mg/kg. The intraperitoneal LD80 in mice is approximately 125 mg/kg. Dimercaprol has been shown in animal experiments to increase brain deposition of arsenite, organic mercury compounds and increase the toxicity of cadmium and lead. Dimercaprol has been shown to induce seizure in animal studies and also is nephrotoxic.
Dimercaprol is a traditional chelating agent developed by British biochemists at Oxford University during World War II. It was developed as an experimental antidote against the arsenic-based poison gas Lewisite. It has been used clinically since 1949 in arsenic, cadmium and mercury poisoning. In addition, it has in the past been used for the treatment of Wilson's disease, a genetic disorder in which the body tends to retain copper. Dimercaprol has toxic potential, and its use may be followed by a variety of adverse effects.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Nitroprusside | Dimercaprol may increase the nephrotoxic activities of Nitroprusside. |
| Iron Dextran | Dimercaprol may increase the nephrotoxic activities of Iron Dextran. |
| Iron | Dimercaprol may increase the nephrotoxic activities of Iron. |
| Ferumoxytol | Dimercaprol may increase the nephrotoxic activities of Ferumoxytol. |
| Prussian blue | Dimercaprol may increase the nephrotoxic activities of Prussian blue. |
| Ferric carboxymaltose | Dimercaprol may increase the nephrotoxic activities of Ferric carboxymaltose. |
| Iron sucrose | Dimercaprol may increase the nephrotoxic activities of Iron sucrose. |
| Ferric pyrophosphate | Dimercaprol may increase the nephrotoxic activities of Ferric pyrophosphate. |
| Ferric ammonium citrate | Dimercaprol may increase the nephrotoxic activities of Ferric ammonium citrate. |
| Ferumoxsil | Dimercaprol may increase the nephrotoxic activities of Ferumoxsil. |
| Ferumoxides | Dimercaprol may increase the nephrotoxic activities of Ferumoxides. |
| Ferric sulfate | Dimercaprol may increase the nephrotoxic activities of Ferric sulfate. |
| Ferrous bisglycinate | Dimercaprol may increase the nephrotoxic activities of Ferrous bisglycinate. |
| Gleptoferron | Dimercaprol may increase the nephrotoxic activities of Gleptoferron. |
| Ferric oxide | Dimercaprol may increase the nephrotoxic activities of Ferric oxide. |
| Perflubutane | Dimercaprol may increase the nephrotoxic activities of Perflubutane. |
| Ferrous sulfate anhydrous | Dimercaprol may increase the nephrotoxic activities of Ferrous sulfate anhydrous. |
| Sodium feredetate | Dimercaprol may increase the nephrotoxic activities of Sodium feredetate. |
| Ferric hydroxide | Dimercaprol may increase the nephrotoxic activities of Ferric hydroxide. |
| Ferrous chloride | Dimercaprol may increase the nephrotoxic activities of Ferrous chloride. |
| Ferric cation | Dimercaprol may increase the nephrotoxic activities of Ferric cation. |
| Ferrous gluconate | Dimercaprol may increase the nephrotoxic activities of Ferrous gluconate. |
| Ferrous succinate | Dimercaprol may increase the nephrotoxic activities of Ferrous succinate. |
| Ferrous fumarate | Dimercaprol may increase the nephrotoxic activities of Ferrous fumarate. |
| Tetraferric tricitrate decahydrate | Dimercaprol may increase the nephrotoxic activities of Tetraferric tricitrate decahydrate. |
| Ferric oxyhydroxide | Dimercaprol may increase the nephrotoxic activities of Ferric oxyhydroxide. |
| Ferric maltol | Dimercaprol may increase the nephrotoxic activities of Ferric maltol. |
| Iron isomaltoside 1000 | Dimercaprol may increase the nephrotoxic activities of Iron isomaltoside 1000. |
| Iron polymaltose | Dimercaprol may increase the nephrotoxic activities of Iron polymaltose. |
| Technetium Tc-99m oxidronate | Dimercaprol may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent. |
| Cyclosporine | Cyclosporine may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Icosapent | Icosapent may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefotiam | Cefotiam may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Mesalazine | Mesalazine may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefmenoxime | Cefmenoxime may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefmetazole | Cefmetazole may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Pamidronic acid | Pamidronic acid may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Tenofovir disoproxil | Tenofovir disoproxil may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Indomethacin | Indomethacin may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cidofovir | Cidofovir may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefpiramide | Cefpiramide may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Ceftazidime | Ceftazidime may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Loracarbef | Loracarbef may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefalotin | Cefalotin may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Nabumetone | Nabumetone may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Ketorolac | Ketorolac may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Tenoxicam | Tenoxicam may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Celecoxib | Celecoxib may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefotaxime | Cefotaxime may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Tolmetin | Tolmetin may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Foscarnet | Foscarnet may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Rofecoxib | Rofecoxib may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Piroxicam | Piroxicam may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Methotrexate | Methotrexate may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cephalexin | Cephalexin may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Fenoprofen | Fenoprofen may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Valaciclovir | Valaciclovir may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Valdecoxib | Valdecoxib may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Diclofenac | Diclofenac may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Sulindac | Sulindac may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Bacitracin | Bacitracin may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Amphotericin B | Amphotericin B may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cephaloglycin | Cephaloglycin may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Flurbiprofen | Flurbiprofen may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Adefovir dipivoxil | Adefovir dipivoxil may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Pentamidine | Pentamidine may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Etodolac | Etodolac may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Mefenamic acid | Mefenamic acid may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Acyclovir | Acyclovir may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Naproxen | Naproxen may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Sulfasalazine | Sulfasalazine may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Phenylbutazone | Phenylbutazone may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Meloxicam | Meloxicam may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Carprofen | Carprofen may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefaclor | Cefaclor may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Diflunisal | Diflunisal may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Tacrolimus | Tacrolimus may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Ceforanide | Ceforanide may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Salicylic acid | Salicylic acid may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Meclofenamic acid | Meclofenamic acid may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Acetylsalicylic acid | Acetylsalicylic acid may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Carboplatin | Carboplatin may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Oxaprozin | Oxaprozin may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Ketoprofen | Ketoprofen may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Balsalazide | Balsalazide may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Ibuprofen | Ibuprofen may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefditoren | Cefditoren may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Atazanavir | Atazanavir may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Colistimethate | Colistimethate may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefuroxime | Cefuroxime may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefapirin | Cefapirin may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefadroxil | Cefadroxil may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefprozil | Cefprozil may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Ceftriaxone | Ceftriaxone may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Olsalazine | Olsalazine may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Lumiracoxib | Lumiracoxib may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefamandole | Cefamandole may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefazolin | Cefazolin may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefonicid | Cefonicid may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |
| Cefoperazone | Cefoperazone may decrease the excretion rate of Dimercaprol which could result in a higher serum level. |