Preclinical pharmacokinetic and toxicity studies have established that difluprednate ophthalmic emulsion 0.05% given 4 times a day is not toxic to the eye.
Difluprednate is a topical corticosteroid indicated for the treatment of infammation and pain associated with ocular surgery. It is a butyrate ester of 6(?), 9(?)-difluoro prednisolone acetate. Difluprednate is abbreviated DFBA, or difluoroprednisolone butyrate acetate. It is indicated for treatment of endogenous anterior uveiti.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Trastuzumab | The risk or severity of neutropenia can be increased when Trastuzumab is combined with Difluprednate. |
| Tacrolimus | Tacrolimus may increase the immunosuppressive activities of Difluprednate. |
| Phenylephrine | The risk or severity of hypertension can be increased when Difluprednate is combined with Phenylephrine. |
| Aminoglutethimide | The therapeutic efficacy of Difluprednate can be decreased when used in combination with Aminoglutethimide. |
| Insulin human | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Insulin human. |
| Insulin lispro | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Insulin lispro. |
| Insulin glargine | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Insulin glargine. |
| Insulin pork | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Insulin pork. |
| Troglitazone | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Troglitazone. |
| Glimepiride | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Glimepiride. |
| Sulfisoxazole | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Sulfisoxazole. |
| Disopyramide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Disopyramide. |
| Acarbose | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Acarbose. |
| Metformin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Metformin. |
| Sulfadiazine | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Sulfadiazine. |
| Rosiglitazone | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Rosiglitazone. |
| Acetohexamide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Acetohexamide. |
| Quinine | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Quinine. |
| Miglitol | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Miglitol. |
| Chlorpropamide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Chlorpropamide. |
| Nateglinide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Nateglinide. |
| Pentamidine | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Pentamidine. |
| Mifepristone | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Mifepristone. |
| Tolazamide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Tolazamide. |
| Repaglinide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Repaglinide. |
| Phenformin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Phenformin. |
| Sulfamethoxazole | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Sulfamethoxazole. |
| Glyburide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Glyburide. |
| Glipizide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Glipizide. |
| Gliclazide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Gliclazide. |
| Tolbutamide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Tolbutamide. |
| Pioglitazone | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Pioglitazone. |
| Bromocriptine | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Bromocriptine. |
| Gliquidone | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Gliquidone. |
| Mitiglinide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Mitiglinide. |
| Sitagliptin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Sitagliptin. |
| Sunitinib | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Sunitinib. |
| Exenatide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Exenatide. |
| Mecasermin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Mecasermin. |
| Pramlintide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Pramlintide. |
| Glisoxepide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Glisoxepide. |
| Insulin aspart | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Insulin aspart. |
| Insulin detemir | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Insulin detemir. |
| Insulin glulisine | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Insulin glulisine. |
| Glymidine | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Glymidine. |
| AICA ribonucleotide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with AICA ribonucleotide. |
| Buformin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Buformin. |
| Vildagliptin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Vildagliptin. |
| Voglibose | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Voglibose. |
| NN344 | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with NN344. |
| AMG-222 | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with AMG-222. |
| Bisegliptin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Bisegliptin. |
| Alogliptin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Alogliptin. |
| Dapagliflozin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Dapagliflozin. |
| Saxagliptin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Saxagliptin. |
| Liraglutide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Liraglutide. |
| Gosogliptin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Gosogliptin. |
| Linagliptin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Linagliptin. |
| Canagliflozin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Canagliflozin. |
| Glibornuride | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Glibornuride. |
| Benfluorex | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Benfluorex. |
| Empagliflozin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Empagliflozin. |
| Albiglutide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Albiglutide. |
| Dulaglutide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Dulaglutide. |
| Lobeglitazone | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Lobeglitazone. |
| Netoglitazone | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Netoglitazone. |
| Rivoglitazone | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Rivoglitazone. |
| Ciglitazone | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Ciglitazone. |
| Lixisenatide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Lixisenatide. |
| Insulin beef | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Insulin beef. |
| Insulin degludec | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Insulin degludec. |
| Insulin peglispro | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Insulin peglispro. |
| Insulin tregopil | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Insulin tregopil. |
| Ipragliflozin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Ipragliflozin. |
| Dutogliptin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Dutogliptin. |
| Allicin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Allicin. |
| Tofogliflozin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Tofogliflozin. |
| Ertugliflozin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Ertugliflozin. |
| 2,4-thiazolidinedione | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with 2,4-thiazolidinedione. |
| Teneligliptin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Teneligliptin. |
| Omarigliptin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Omarigliptin. |
| Carmegliptin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Carmegliptin. |
| Gemigliptin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Gemigliptin. |
| Anagliptin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Anagliptin. |
| Evogliptin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Evogliptin. |
| Sotagliflozin | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Sotagliflozin. |
| Balaglitazone | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Balaglitazone. |
| Remogliflozin etabonate | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Remogliflozin etabonate. |
| Carbutamide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Carbutamide. |
| Guar gum | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Guar gum. |
| Metahexamide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Metahexamide. |
| Semaglutide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Semaglutide. |
| Taspoglutide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Taspoglutide. |
| Englitazone | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Englitazone. |
| Tirzepatide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Tirzepatide. |
| Gastric inhibitory polypeptide | The risk or severity of hyperglycemia can be increased when Difluprednate is combined with Gastric inhibitory polypeptide. |
| Isoniazid | The serum concentration of Isoniazid can be decreased when it is combined with Difluprednate. |
| Cyclosporine | The risk or severity of adverse effects can be increased when Difluprednate is combined with Cyclosporine. |
| Digoxin | The risk or severity of adverse effects can be increased when Difluprednate is combined with Digoxin. |
| Acetyldigitoxin | The risk or severity of adverse effects can be increased when Difluprednate is combined with Acetyldigitoxin. |