Peringatan Keamanan

1250 mg/kg (rat, oral) LD50
400 mg/kg IPR-RAT LD50
2000 mg/kg SKN-RBT LD50
53 mg/kg IVN-RAT LD50
2500 mg/kg ORL-GPG LD50

Benzyl alcohol

DB06770

small molecule approved

Deskripsi

Struktur Molekul 2D

Berat 108.1378
Wujud liquid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1969 Data
Deferasirox The serum concentration of Benzyl alcohol can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Benzyl alcohol can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Benzyl alcohol can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Benzyl alcohol can be decreased when it is combined with Teriflunomide.
Buprenorphine Benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.
Hydrocodone Benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.
Magnesium sulfate The therapeutic efficacy of Benzyl alcohol can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Benzyl alcohol may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.
Mirtazapine Benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.
Orphenadrine Benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.
Pramipexole Benzyl alcohol may increase the sedative activities of Pramipexole.
Ropinirole Benzyl alcohol may increase the sedative activities of Ropinirole.
Rotigotine Benzyl alcohol may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Benzyl alcohol.
Sodium oxybate Benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.
Thalidomide Benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Hyaluronidase (ovine) Hyaluronidase (ovine) can cause an increase in the absorption of Benzyl alcohol resulting in an increased serum concentration and potentially a worsening of adverse effects.
Hyaluronidase (human recombinant) Hyaluronidase (human recombinant) can cause an increase in the absorption of Benzyl alcohol resulting in an increased serum concentration and potentially a worsening of adverse effects.
Hyaluronidase Hyaluronidase can cause an increase in the absorption of Benzyl alcohol resulting in an increased serum concentration and potentially a worsening of adverse effects.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Benzyl alcohol.
Mifepristone The serum concentration of Benzyl alcohol can be increased when it is combined with Mifepristone.
Mirabegron The serum concentration of Benzyl alcohol can be increased when it is combined with Mirabegron.
Abiraterone The serum concentration of Benzyl alcohol can be increased when it is combined with Abiraterone.
Cyproterone acetate The metabolism of Benzyl alcohol can be increased when combined with Cyproterone acetate.
Ethanol Benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Benzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Benzyl alcohol.
Citalopram The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Citalopram.
Trazodone The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Trazodone.
Sertraline The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Nefazodone.
Zimelidine The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Milnacipran.
Desvenlafaxine The serum concentration of Benzyl alcohol can be increased when it is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Indalpine.
Alaproclate The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Alaproclate.
Technetium Tc-99m tilmanocept Benzyl alcohol may decrease effectiveness of Technetium Tc-99m tilmanocept as a diagnostic agent.
Trospium The metabolism of Benzyl alcohol can be decreased when combined with Trospium.
Benzatropine The metabolism of Benzyl alcohol can be decreased when combined with Benzatropine.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Benzyl alcohol.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Benzyl alcohol.
Maprotiline The risk or severity of CNS depression can be increased when Maprotiline is combined with Benzyl alcohol.
Tolterodine The metabolism of Benzyl alcohol can be decreased when combined with Tolterodine.
Tiotropium The metabolism of Benzyl alcohol can be decreased when combined with Tiotropium.
Solifenacin The metabolism of Benzyl alcohol can be decreased when combined with Solifenacin.
Pizotifen The risk or severity of CNS depression can be increased when Pizotifen is combined with Benzyl alcohol.
Olanzapine The risk or severity of CNS depression can be increased when Olanzapine is combined with Benzyl alcohol.
Lamotrigine The risk or severity of methemoglobinemia can be increased when Lamotrigine is combined with Benzyl alcohol.
Flupentixol The risk or severity of CNS depression can be increased when Flupentixol is combined with Benzyl alcohol.
Doxepin The risk or severity of CNS depression can be increased when Doxepin is combined with Benzyl alcohol.
Quetiapine The risk or severity of CNS depression can be increased when Quetiapine is combined with Benzyl alcohol.
Fesoterodine The metabolism of Benzyl alcohol can be decreased when combined with Fesoterodine.
Umeclidinium The metabolism of Umeclidinium can be decreased when combined with Benzyl alcohol.
Revefenacin The metabolism of Revefenacin can be decreased when combined with Benzyl alcohol.
Zopiclone The risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Zopiclone.
Albendazole The metabolism of Benzyl alcohol can be increased when combined with Albendazole.
Primidone The risk or severity of methemoglobinemia can be increased when Primidone is combined with Benzyl alcohol.
Carbamazepine The risk or severity of methemoglobinemia can be increased when Carbamazepine is combined with Benzyl alcohol.
Rifampin The risk or severity of methemoglobinemia can be increased when Rifampicin is combined with Benzyl alcohol.
Caffeine The metabolism of Benzyl alcohol can be decreased when combined with Caffeine.
Moxifloxacin The risk or severity of methemoglobinemia can be increased when Moxifloxacin is combined with Benzyl alcohol.
Mexiletine The metabolism of Benzyl alcohol can be decreased when combined with Mexiletine.
Alosetron The metabolism of Benzyl alcohol can be decreased when combined with Alosetron.
Gatifloxacin The risk or severity of methemoglobinemia can be increased when Gatifloxacin is combined with Benzyl alcohol.
Lobeglitazone The metabolism of Benzyl alcohol can be decreased when combined with Lobeglitazone.
Pazufloxacin The risk or severity of methemoglobinemia can be increased when Pazufloxacin is combined with Benzyl alcohol.
Simeprevir The metabolism of Benzyl alcohol can be decreased when combined with Simeprevir.
Osilodrostat The metabolism of Benzyl alcohol can be decreased when combined with Osilodrostat.
Duloxetine The metabolism of Benzyl alcohol can be decreased when combined with Duloxetine.
Ritanserin The metabolism of Benzyl alcohol can be decreased when combined with Ritanserin.
Venlafaxine The risk or severity of CNS depression can be increased when Venlafaxine is combined with Benzyl alcohol.
Clobazam The serum concentration of Benzyl alcohol can be increased when it is combined with Clobazam.
Quinine The metabolism of Benzyl alcohol can be decreased when combined with Quinine.
Chlorpromazine The metabolism of Benzyl alcohol can be decreased when combined with Chlorpromazine.
Cyclosporine The metabolism of Benzyl alcohol can be decreased when combined with Cyclosporine.
Imipramine The metabolism of Benzyl alcohol can be decreased when combined with Imipramine.
Metoprolol The metabolism of Benzyl alcohol can be decreased when combined with Metoprolol.
Terfenadine The metabolism of Benzyl alcohol can be decreased when combined with Terfenadine.
Clozapine The serum concentration of Benzyl alcohol can be increased when it is combined with Clozapine.
Celecoxib The metabolism of Benzyl alcohol can be decreased when combined with Celecoxib.
Cimetidine The metabolism of Benzyl alcohol can be decreased when combined with Cimetidine.
Panobinostat The metabolism of Benzyl alcohol can be decreased when combined with Panobinostat.
Asunaprevir The metabolism of Benzyl alcohol can be decreased when combined with Asunaprevir.
Rucaparib The metabolism of Benzyl alcohol can be decreased when combined with Rucaparib.
Ketoconazole The metabolism of Benzyl alcohol can be decreased when combined with Ketoconazole.

Referensi & Sumber

Synthesis reference: Cornelis Jongsma, Leon H. B. Frijns, Paula A. M. Raven-Donners, "Method for the preparation of a pure alkali metal benzoate and benzyl alcohol." U.S. Patent US4296245, issued June, 1940.
Artikel (PubMed)
  • PMID: 22366290
    Taylor PM, Chengelis CP, Miller WR, Parker GA, Gleason TR, Cozzi E: Evaluation of propofol containing 2% benzyl alcohol preservative in cats. J Feline Med Surg. 2012 Aug;14(8):516-26. doi: 10.1177/1098612X12440354. Epub 2012 Feb 24.
  • PMID: 4560999
    Novak E, Stubbs SS, Sanborn EC, Eustice RM: The tolerance and safety of intravenously administered benzyl alcohol in methylprednisolone sodium succinate formulations in normal human subjects. Toxicol Appl Pharmacol. 1972 Sep;23(1):54-61.
  • PMID: 20199404
    Meinking TL, Villar ME, Vicaria M, Eyerdam DH, Paquet D, Mertz-Rivera K, Rivera HF, Hiriart J, Reyna S: The clinical trials supporting benzyl alcohol lotion 5% (Ulesfia): a safe and effective topical treatment for head lice (pediculosis humanus capitis). Pediatr Dermatol. 2010 Jan-Feb;27(1):19-24. doi: 10.1111/j.1525-1470.2009.01059.x.

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