Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a mucoactive drug with several properties including secretolytic and secretomotoric actions that restore the physiological clearance mechanisms of the respiratory tract which play an important role in the body’s natural defence mechanisms. It stimulates synthesis and release of surfactant by type II pneumocytes. Surfactants acts as an anti-glue factor by reducing the adhesion of mucus to the bronchial wall, in improving its transport and in providing protection against infection and irritating agents.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Pitolisant | The serum concentration of Ambroxol can be decreased when it is combined with Pitolisant. |
| Metreleptin | The metabolism of Ambroxol can be increased when combined with Metreleptin. |
| Cenobamate | The serum concentration of Ambroxol can be decreased when it is combined with Cenobamate. |
| Ritonavir | The serum concentration of Ambroxol can be increased when it is combined with Ritonavir. |
| Haloperidol | The serum concentration of Haloperidol can be increased when it is combined with Ambroxol. |
| Tucatinib | The metabolism of Tucatinib can be decreased when combined with Ambroxol. |
| Abametapir | The serum concentration of Ambroxol can be increased when it is combined with Abametapir. |
| Satralizumab | The serum concentration of Ambroxol can be decreased when it is combined with Satralizumab. |
| Sotorasib | The serum concentration of Ambroxol can be decreased when it is combined with Sotorasib. |
| Cyclosporine | The metabolism of Ambroxol can be decreased when combined with Cyclosporine. |
| Fluvoxamine | The metabolism of Ambroxol can be decreased when combined with Fluvoxamine. |
| Fluconazole | The metabolism of Ambroxol can be decreased when combined with Fluconazole. |
| Erythromycin | The serum concentration of Ambroxol can be increased when it is combined with Erythromycin. |
| Ziprasidone | The metabolism of Ambroxol can be decreased when combined with Ziprasidone. |
| Isradipine | The metabolism of Ambroxol can be decreased when combined with Isradipine. |
| Diltiazem | The metabolism of Ambroxol can be decreased when combined with Diltiazem. |
| Clozapine | The metabolism of Ambroxol can be decreased when combined with Clozapine. |
| Ciprofloxacin | The risk or severity of methemoglobinemia can be increased when Ciprofloxacin is combined with Ambroxol. |
| Nicardipine | The metabolism of Ambroxol can be decreased when combined with Nicardipine. |
| Verapamil | The metabolism of Ambroxol can be decreased when combined with Verapamil. |
| Aprepitant | The metabolism of Ambroxol can be decreased when combined with Aprepitant. |
| Isoniazid | The risk or severity of methemoglobinemia can be increased when Isoniazid is combined with Ambroxol. |
| Primaquine | The risk or severity of methemoglobinemia can be increased when Primaquine is combined with Ambroxol. |
| Miconazole | The metabolism of Ambroxol can be decreased when combined with Miconazole. |
| Fusidic acid | The risk or severity of methemoglobinemia can be increased when Fusidic acid is combined with Ambroxol. |
| Zimelidine | The metabolism of Ambroxol can be decreased when combined with Zimelidine. |
| Dronedarone | The metabolism of Ambroxol can be decreased when combined with Dronedarone. |
| Milnacipran | The metabolism of Ambroxol can be decreased when combined with Milnacipran. |
| Simeprevir | The metabolism of Ambroxol can be decreased when combined with Simeprevir. |
| Isavuconazonium | The metabolism of Ambroxol can be decreased when combined with Isavuconazonium. |
| Desvenlafaxine | The metabolism of Ambroxol can be decreased when combined with Desvenlafaxine. |
| Nilvadipine | The metabolism of Ambroxol can be decreased when combined with Nilvadipine. |
| Seproxetine | The metabolism of Ambroxol can be decreased when combined with Seproxetine. |
| Crizotinib | The risk or severity of methemoglobinemia can be increased when Crizotinib is combined with Ambroxol. |
| Linagliptin | The metabolism of Ambroxol can be decreased when combined with Linagliptin. |
| Indalpine | The metabolism of Ambroxol can be decreased when combined with Indalpine. |
| Netupitant | The metabolism of Ambroxol can be decreased when combined with Netupitant. |
| Barnidipine | The metabolism of Ambroxol can be decreased when combined with Barnidipine. |
| Benidipine | The metabolism of Ambroxol can be decreased when combined with Benidipine. |
| Venetoclax | The risk or severity of methemoglobinemia can be increased when Venetoclax is combined with Ambroxol. |
| Isavuconazole | The metabolism of Ambroxol can be decreased when combined with Isavuconazole. |
| Fosnetupitant | The metabolism of Ambroxol can be decreased when combined with Fosnetupitant. |
| Berotralstat | The metabolism of Ambroxol can be decreased when combined with Berotralstat. |
| Midostaurin | The metabolism of Ambroxol can be decreased when combined with Midostaurin. |
| Voriconazole | The metabolism of Ambroxol can be decreased when combined with Voriconazole. |
| Danazol | The metabolism of Ambroxol can be decreased when combined with Danazol. |
| Nelfinavir | The metabolism of Ambroxol can be decreased when combined with Nelfinavir. |
| Indinavir | The metabolism of Ambroxol can be decreased when combined with Indinavir. |
| Terfenadine | The metabolism of Ambroxol can be decreased when combined with Terfenadine. |
| Efavirenz | The metabolism of Ambroxol can be decreased when combined with Efavirenz. |
| Ergotamine | The metabolism of Ambroxol can be decreased when combined with Ergotamine. |
| Amprenavir | The metabolism of Ambroxol can be decreased when combined with Amprenavir. |
| Delavirdine | The metabolism of Ambroxol can be decreased when combined with Delavirdine. |
| Methimazole | The metabolism of Ambroxol can be decreased when combined with Methimazole. |
| Conivaptan | The metabolism of Ambroxol can be decreased when combined with Conivaptan. |
| Tipranavir | The metabolism of Ambroxol can be decreased when combined with Tipranavir. |
| Telithromycin | The metabolism of Ambroxol can be decreased when combined with Telithromycin. |
| Ketoconazole | The metabolism of Ambroxol can be decreased when combined with Ketoconazole. |
| Atazanavir | The metabolism of Ambroxol can be decreased when combined with Atazanavir. |
| Amiodarone | The metabolism of Ambroxol can be decreased when combined with Amiodarone. |
| Nefazodone | The metabolism of Ambroxol can be decreased when combined with Nefazodone. |
| Itraconazole | The metabolism of Ambroxol can be decreased when combined with Itraconazole. |
| Saquinavir | The metabolism of Ambroxol can be decreased when combined with Saquinavir. |
| Posaconazole | The metabolism of Ambroxol can be decreased when combined with Posaconazole. |
| Darunavir | The metabolism of Ambroxol can be decreased when combined with Darunavir. |
| Lopinavir | The metabolism of Ambroxol can be decreased when combined with Lopinavir. |
| Ditiocarb | The metabolism of Ambroxol can be decreased when combined with Ditiocarb. |
| Nilotinib | The metabolism of Ambroxol can be decreased when combined with Nilotinib. |
| Telaprevir | The metabolism of Ambroxol can be decreased when combined with Telaprevir. |
| Lonafarnib | The metabolism of Ambroxol can be decreased when combined with Lonafarnib. |
| Boceprevir | The metabolism of Ambroxol can be decreased when combined with Boceprevir. |
| Elvitegravir | The metabolism of Ambroxol can be decreased when combined with Elvitegravir. |
| Stiripentol | The metabolism of Ambroxol can be decreased when combined with Stiripentol. |
| Ribociclib | The metabolism of Ambroxol can be decreased when combined with Ribociclib. |
| Danoprevir | The metabolism of Ambroxol can be decreased when combined with Danoprevir. |
| Troleandomycin | The metabolism of Ambroxol can be decreased when combined with Troleandomycin. |
| Phenytoin | The risk or severity of methemoglobinemia can be increased when Phenytoin is combined with Ambroxol. |
| Pentobarbital | The risk or severity of methemoglobinemia can be increased when Pentobarbital is combined with Ambroxol. |
| Carbamazepine | The risk or severity of methemoglobinemia can be increased when Carbamazepine is combined with Ambroxol. |
| Mitotane | The risk or severity of methemoglobinemia can be increased when Mitotane is combined with Ambroxol. |
| Primidone | The risk or severity of methemoglobinemia can be increased when Primidone is combined with Ambroxol. |
| Rifampin | The risk or severity of methemoglobinemia can be increased when Rifampicin is combined with Ambroxol. |
| Phenobarbital | The risk or severity of methemoglobinemia can be increased when Phenobarbital is combined with Ambroxol. |
| Dexamethasone | The risk or severity of methemoglobinemia can be increased when Dexamethasone is combined with Ambroxol. |
| Fosphenytoin | The risk or severity of methemoglobinemia can be increased when Fosphenytoin is combined with Ambroxol. |
| St. John's Wort | The metabolism of Ambroxol can be increased when combined with St. John's Wort. |
| Enzalutamide | The serum concentration of Ambroxol can be decreased when it is combined with Enzalutamide. |
| Lumacaftor | The metabolism of Ambroxol can be increased when combined with Lumacaftor. |
| Rifamycin | The risk or severity of methemoglobinemia can be increased when Rifamycin is combined with Ambroxol. |
| Apalutamide | The serum concentration of Ambroxol can be decreased when it is combined with Apalutamide. |
| Rifapentine | The risk or severity of methemoglobinemia can be increased when Rifapentine is combined with Ambroxol. |
| Curcumin | The metabolism of Ambroxol can be decreased when combined with Curcumin. |
| Somatrogon | The metabolism of Ambroxol can be increased when combined with Somatrogon. |
| Levoketoconazole | The metabolism of Ambroxol can be decreased when combined with Levoketoconazole. |
| Mavacamten | The serum concentration of Ambroxol can be decreased when it is combined with Mavacamten. |
| Viloxazine | The metabolism of Ambroxol can be decreased when combined with Viloxazine. |
| Ivosidenib | The metabolism of Ambroxol can be increased when combined with Ivosidenib. |
| Dabrafenib | The serum concentration of Ambroxol can be decreased when it is combined with Dabrafenib. |
| Telotristat ethyl | The serum concentration of Ambroxol can be decreased when it is combined with Telotristat ethyl. |
| Avanafil | The serum concentration of Avanafil can be increased when it is combined with Ambroxol. |