Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM). Gavestinel displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites and is orally bioavailable and active in vivo.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Nelfinavir | The metabolism of Gavestinel can be increased when combined with Nelfinavir. |
| Phenytoin | The metabolism of Gavestinel can be increased when combined with Phenytoin. |
| Desogestrel | The metabolism of Gavestinel can be increased when combined with Desogestrel. |
| Zidovudine | The metabolism of Gavestinel can be increased when combined with Zidovudine. |
| Ritonavir | The metabolism of Gavestinel can be increased when combined with Ritonavir. |
| Lamotrigine | The metabolism of Gavestinel can be increased when combined with Lamotrigine. |
| Carbamazepine | The metabolism of Gavestinel can be increased when combined with Carbamazepine. |
| Efavirenz | The metabolism of Gavestinel can be increased when combined with Efavirenz. |
| Primidone | The metabolism of Gavestinel can be increased when combined with Primidone. |
| Tipranavir | The metabolism of Gavestinel can be increased when combined with Tipranavir. |
| Ethinylestradiol | The metabolism of Gavestinel can be increased when combined with Ethinylestradiol. |
| Rifampin | The metabolism of Gavestinel can be increased when combined with Rifampicin. |
| Phenobarbital | The metabolism of Gavestinel can be increased when combined with Phenobarbital. |
| Testosterone propionate | The metabolism of Gavestinel can be increased when combined with Testosterone propionate. |
| Adenine | The metabolism of Gavestinel can be decreased when combined with Adenine. |
| Indinavir | The metabolism of Gavestinel can be decreased when combined with Indinavir. |
| Valproic acid | The metabolism of Gavestinel can be decreased when combined with Valproic acid. |
| Amitriptyline | The metabolism of Gavestinel can be decreased when combined with Amitriptyline. |
| Indomethacin | The metabolism of Gavestinel can be decreased when combined with Indomethacin. |
| Sorafenib | The metabolism of Gavestinel can be decreased when combined with Sorafenib. |
| Erlotinib | The metabolism of Gavestinel can be decreased when combined with Erlotinib. |
| Flurbiprofen | The metabolism of Gavestinel can be decreased when combined with Flurbiprofen. |
| Propofol | The metabolism of Gavestinel can be decreased when combined with Propofol. |
| Ketoconazole | The metabolism of Gavestinel can be decreased when combined with Ketoconazole. |
| Probenecid | The metabolism of Gavestinel can be decreased when combined with Probenecid. |
| Atazanavir | The metabolism of Gavestinel can be decreased when combined with Atazanavir. |
| Gemfibrozil | The metabolism of Gavestinel can be decreased when combined with Gemfibrozil. |
| Flunitrazepam | The metabolism of Gavestinel can be decreased when combined with Flunitrazepam. |
| Deferasirox | The metabolism of Gavestinel can be decreased when combined with Deferasirox. |
| Nilotinib | The metabolism of Gavestinel can be decreased when combined with Nilotinib. |
| Eltrombopag | The metabolism of Gavestinel can be decreased when combined with Eltrombopag. |
| Pazopanib | The metabolism of Gavestinel can be decreased when combined with Pazopanib. |
| Regorafenib | The metabolism of Gavestinel can be decreased when combined with Regorafenib. |
| Dasabuvir | The metabolism of Gavestinel can be decreased when combined with Dasabuvir. |
| Sodium aurothiomalate | The metabolism of Gavestinel can be decreased when combined with Sodium aurothiomalate. |
| Ombitasvir | The metabolism of Gavestinel can be decreased when combined with Ombitasvir. |
| Paritaprevir | The metabolism of Gavestinel can be decreased when combined with Paritaprevir. |
| Silibinin | The metabolism of Gavestinel can be decreased when combined with Silibinin. |
| Dacomitinib | The metabolism of Gavestinel can be decreased when combined with Dacomitinib. |
| Fostamatinib | The metabolism of Gavestinel can be decreased when combined with Fostamatinib. |
| Enasidenib | The metabolism of Gavestinel can be decreased when combined with Enasidenib. |
| Pibrentasvir | The metabolism of Gavestinel can be decreased when combined with Pibrentasvir. |
| Glecaprevir | The metabolism of Gavestinel can be decreased when combined with Glecaprevir. |
| Pexidartinib | The metabolism of Gavestinel can be decreased when combined with Pexidartinib. |
| Mefenamic acid | The metabolism of Gavestinel can be decreased when combined with Mefenamic acid. |
| Diflunisal | The metabolism of Gavestinel can be decreased when combined with Diflunisal. |
| Fosphenytoin | The metabolism of Gavestinel can be decreased when combined with Fosphenytoin. |
| Isavuconazole | The metabolism of Gavestinel can be decreased when combined with Isavuconazole. |
| Umifenovir | The metabolism of Gavestinel can be decreased when combined with Umifenovir. |
| Methylene blue | The metabolism of Gavestinel can be decreased when combined with Methylene blue. |
| Niflumic acid | The metabolism of Gavestinel can be decreased when combined with Niflumic acid. |
| Cannabidiol | The metabolism of Gavestinel can be decreased when combined with Cannabidiol. |
| Dovitinib | The metabolism of Gavestinel can be decreased when combined with Dovitinib. |
| Asciminib | The metabolism of Gavestinel can be decreased when combined with Asciminib. |
| Mitapivat | The metabolism of Gavestinel can be increased when combined with Mitapivat. |
| Dabrafenib | The metabolism of Gavestinel can be decreased when combined with Dabrafenib. |
| Quizartinib | The metabolism of Gavestinel can be decreased when combined with Quizartinib. |
| Repotrectinib | The metabolism of Gavestinel can be decreased when combined with Repotrectinib. |
| Encorafenib | The metabolism of Gavestinel can be decreased when combined with Encorafenib. |