The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus. These compounds all appear in the same fermentation and have similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase). The most commonly utilized bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Dicoumarol | The therapeutic efficacy of Dicoumarol can be increased when used in combination with Bafilomycin A1. |
| Phenindione | The therapeutic efficacy of Phenindione can be increased when used in combination with Bafilomycin A1. |
| Warfarin | The therapeutic efficacy of Warfarin can be increased when used in combination with Bafilomycin A1. |
| Phenprocoumon | The therapeutic efficacy of Phenprocoumon can be increased when used in combination with Bafilomycin A1. |
| Acenocoumarol | The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Bafilomycin A1. |
| 4-hydroxycoumarin | The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Bafilomycin A1. |
| Coumarin | The therapeutic efficacy of Coumarin can be increased when used in combination with Bafilomycin A1. |
| (R)-warfarin | The therapeutic efficacy of (R)-warfarin can be increased when used in combination with Bafilomycin A1. |
| Ethyl biscoumacetate | The therapeutic efficacy of Ethyl biscoumacetate can be increased when used in combination with Bafilomycin A1. |
| Fluindione | The therapeutic efficacy of Fluindione can be increased when used in combination with Bafilomycin A1. |
| Clorindione | The therapeutic efficacy of Clorindione can be increased when used in combination with Bafilomycin A1. |
| Diphenadione | The therapeutic efficacy of Diphenadione can be increased when used in combination with Bafilomycin A1. |
| Tioclomarol | The therapeutic efficacy of Tioclomarol can be increased when used in combination with Bafilomycin A1. |
| (S)-Warfarin | The therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Bafilomycin A1. |