Gestodene

DB06730

small molecule investigational

Deskripsi

Gestodene is a progestogen hormonal contraceptive. Products containing gestoden include Meliane, which contains 20 mcg of ethinylestradiol and 75 mcg of gestodene; and Gynera, which contains 30 mcg of ethinylestradiol and 75 mcg of gestodene.

Struktur Molekul 2D

Berat 310.4299
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 16 to 18 hrs.
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

in vitro 99% using 3H=R5020 / in vivo similar to progesterone

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

704 Data
Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Gestodene.
Acitretin The therapeutic efficacy of Gestodene can be decreased when used in combination with Acitretin.
Atazanavir The serum concentration of Gestodene can be increased when it is combined with Atazanavir.
Boceprevir The serum concentration of Gestodene can be increased when it is combined with Boceprevir.
Prucalopride The serum concentration of Gestodene can be decreased when it is combined with Prucalopride.
Sugammadex The serum concentration of Gestodene can be decreased when it is combined with Sugammadex.
Thalidomide Gestodene may increase the thrombogenic activities of Thalidomide.
Ulipristal The therapeutic efficacy of Gestodene can be decreased when used in combination with Ulipristal.
Ursodeoxycholic acid The therapeutic efficacy of Ursodeoxycholic acid can be decreased when used in combination with Gestodene.
Glycochenodeoxycholic Acid The therapeutic efficacy of Glycochenodeoxycholic Acid can be decreased when used in combination with Gestodene.
Cholic Acid The therapeutic efficacy of Cholic Acid can be decreased when used in combination with Gestodene.
Glycocholic acid The therapeutic efficacy of Glycocholic acid can be decreased when used in combination with Gestodene.
Deoxycholic acid The therapeutic efficacy of Deoxycholic acid can be decreased when used in combination with Gestodene.
Taurocholic acid The therapeutic efficacy of Taurocholic acid can be decreased when used in combination with Gestodene.
Obeticholic acid The therapeutic efficacy of Obeticholic acid can be decreased when used in combination with Gestodene.
Tauroursodeoxycholic acid The therapeutic efficacy of Tauroursodeoxycholic acid can be decreased when used in combination with Gestodene.
Bamet-UD2 The therapeutic efficacy of Bamet-UD2 can be decreased when used in combination with Gestodene.
cis-Diamminechlorocholylglycinateplatinum(II) The therapeutic efficacy of cis-Diamminechlorocholylglycinateplatinum(II) can be decreased when used in combination with Gestodene.
Dehydrocholic acid The therapeutic efficacy of Dehydrocholic acid can be decreased when used in combination with Gestodene.
Hyodeoxycholic Acid The therapeutic efficacy of Hyodeoxycholic Acid can be decreased when used in combination with Gestodene.
Aramchol The therapeutic efficacy of Aramchol can be decreased when used in combination with Gestodene.
Ox bile extract The therapeutic efficacy of Ox bile extract can be decreased when used in combination with Gestodene.
Chenodeoxycholic acid The therapeutic efficacy of Chenodeoxycholic acid can be decreased when used in combination with Gestodene.
Taurochenodeoxycholic acid The therapeutic efficacy of Taurochenodeoxycholic acid can be decreased when used in combination with Gestodene.
Tranexamic acid Gestodene may increase the thrombogenic activities of Tranexamic acid.
Clobazam The serum concentration of Gestodene can be decreased when it is combined with Clobazam.
Colestipol Colestipol can cause a decrease in the absorption of Gestodene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sevelamer Sevelamer can cause a decrease in the absorption of Gestodene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Colesevelam Colesevelam can cause a decrease in the absorption of Gestodene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cholestyramine Cholestyramine can cause a decrease in the absorption of Gestodene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Griseofulvin The metabolism of Gestodene can be increased when combined with Griseofulvin.
Tixocortol The serum concentration of Tixocortol can be increased when it is combined with Gestodene.
Fluocortin The serum concentration of Fluocortin can be increased when it is combined with Gestodene.
Fluperolone The serum concentration of Fluperolone can be increased when it is combined with Gestodene.
Fluclorolone The serum concentration of Fluclorolone can be increased when it is combined with Gestodene.
Flunisolide The serum concentration of Flunisolide can be increased when it is combined with Gestodene.
Beclomethasone dipropionate The serum concentration of Beclomethasone dipropionate can be increased when it is combined with Gestodene.
Betamethasone The serum concentration of Betamethasone can be increased when it is combined with Gestodene.
Fluocinolone acetonide The serum concentration of Fluocinolone acetonide can be increased when it is combined with Gestodene.
Triamcinolone The serum concentration of Triamcinolone can be increased when it is combined with Gestodene.
Prednisone The serum concentration of Prednisone can be increased when it is combined with Gestodene.
Hydrocortisone The serum concentration of Hydrocortisone can be increased when it is combined with Gestodene.
Prednisolone The serum concentration of Prednisolone can be increased when it is combined with Gestodene.
Methylprednisolone The serum concentration of Methylprednisolone can be increased when it is combined with Gestodene.
Corticotropin The serum concentration of Corticotropin can be increased when it is combined with Gestodene.
Cortisone acetate The serum concentration of Cortisone acetate can be increased when it is combined with Gestodene.
Fluprednidene The serum concentration of Fluprednidene can be increased when it is combined with Gestodene.
Meprednisone The serum concentration of Meprednisone can be increased when it is combined with Gestodene.
Dexamethasone isonicotinate The serum concentration of Dexamethasone isonicotinate can be increased when it is combined with Gestodene.
Deflazacort The serum concentration of Deflazacort can be increased when it is combined with Gestodene.
Cortivazol The serum concentration of Cortivazol can be increased when it is combined with Gestodene.
Prednylidene The serum concentration of Prednylidene can be increased when it is combined with Gestodene.
Cloprednol The serum concentration of Cloprednol can be increased when it is combined with Gestodene.
Mometasone furoate The serum concentration of Mometasone furoate can be increased when it is combined with Gestodene.
Hydrocortisone acetate The serum concentration of Hydrocortisone acetate can be increased when it is combined with Gestodene.
Hydrocortisone succinate The serum concentration of Hydrocortisone succinate can be increased when it is combined with Gestodene.
Prednisolone phosphate The serum concentration of Prednisolone phosphate can be increased when it is combined with Gestodene.
Prednisolone hemisuccinate The serum concentration of Prednisolone hemisuccinate can be increased when it is combined with Gestodene.
Methylprednisolone hemisuccinate The serum concentration of Methylprednisolone hemisuccinate can be increased when it is combined with Gestodene.
Prednisone acetate The serum concentration of Prednisone acetate can be increased when it is combined with Gestodene.
Clocortolone acetate The serum concentration of Clocortolone acetate can be increased when it is combined with Gestodene.
Melengestrol acetate The serum concentration of Melengestrol acetate can be increased when it is combined with Gestodene.
Betamethasone phosphate The serum concentration of Betamethasone phosphate can be increased when it is combined with Gestodene.
Cortisone The serum concentration of Cortisone can be increased when it is combined with Gestodene.
Fluticasone propionate The serum concentration of Fluticasone propionate can be increased when it is combined with Gestodene.
Fluticasone furoate The serum concentration of Fluticasone furoate can be increased when it is combined with Gestodene.
Fluticasone The serum concentration of Fluticasone can be increased when it is combined with Gestodene.
Hydrocortisone cypionate The serum concentration of Hydrocortisone cypionate can be increased when it is combined with Gestodene.
Fludrocortisone The serum concentration of Fludrocortisone can be increased when it is combined with Gestodene.
Trilostane The serum concentration of Trilostane can be increased when it is combined with Gestodene.
Budesonide The serum concentration of Budesonide can be increased when it is combined with Gestodene.
Dexamethasone The serum concentration of Dexamethasone can be increased when it is combined with Gestodene.
Paramethasone The serum concentration of Paramethasone can be increased when it is combined with Gestodene.
Ciclesonide The serum concentration of Ciclesonide can be increased when it is combined with Gestodene.
Aldosterone The serum concentration of Aldosterone can be increased when it is combined with Gestodene.
Fluprednisolone The serum concentration of Fluprednisolone can be increased when it is combined with Gestodene.
Melengestrol The serum concentration of Melengestrol can be increased when it is combined with Gestodene.
Clobetasol propionate The serum concentration of Clobetasol propionate can be increased when it is combined with Gestodene.
Fluocinonide The serum concentration of Fluocinonide can be increased when it is combined with Gestodene.
Hydrocortisone butyrate The serum concentration of Hydrocortisone butyrate can be increased when it is combined with Gestodene.
Desoximetasone The serum concentration of Desoximetasone can be increased when it is combined with Gestodene.
Mometasone The serum concentration of Mometasone can be increased when it is combined with Gestodene.
Fluocortolone The serum concentration of Fluocortolone can be increased when it is combined with Gestodene.
Prednisolone acetate The serum concentration of Prednisolone acetate can be increased when it is combined with Gestodene.
Fluorometholone The serum concentration of Fluorometholone can be increased when it is combined with Gestodene.
Difluocortolone The serum concentration of Difluocortolone can be increased when it is combined with Gestodene.
Flumethasone The serum concentration of Flumethasone can be increased when it is combined with Gestodene.
Methylprednisolone aceponate The serum concentration of Methylprednisolone aceponate can be increased when it is combined with Gestodene.
Vitamin A The therapeutic efficacy of Gestodene can be decreased when used in combination with Vitamin A.
Bexarotene The therapeutic efficacy of Gestodene can be decreased when used in combination with Bexarotene.
Alitretinoin The therapeutic efficacy of Gestodene can be decreased when used in combination with Alitretinoin.
Tretinoin The therapeutic efficacy of Gestodene can be decreased when used in combination with Tretinoin.
Tazarotene The therapeutic efficacy of Gestodene can be decreased when used in combination with Tazarotene.
Etretinate The therapeutic efficacy of Gestodene can be decreased when used in combination with Etretinate.
Isotretinoin The therapeutic efficacy of Gestodene can be decreased when used in combination with Isotretinoin.
4-Oxoretinol The therapeutic efficacy of Gestodene can be decreased when used in combination with 4-Oxoretinol.
Fenretinide The therapeutic efficacy of Gestodene can be decreased when used in combination with Fenretinide.
Ro 12-7310 The therapeutic efficacy of Gestodene can be decreased when used in combination with Ro 12-7310.
Zuretinol acetate The therapeutic efficacy of Gestodene can be decreased when used in combination with Zuretinol acetate.
Motretinide The therapeutic efficacy of Gestodene can be decreased when used in combination with Motretinide.

Target Protein

Progesterone receptor PGR

Referensi & Sumber

Synthesis reference: Rino Prendin, Silvio Pirovano, "Process for the preparation of gestodene." U.S. Patent US5719300, issued March, 1994.

Contoh Produk & Brand

Produk: 1 • International brands: 0
Produk
  • Myvlar
    Tablet • - • Oral • US • OTC

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