Fosaprepitant

DB06717

small molecule approved

Deskripsi

Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment.

Struktur Molekul 2D

Berat 614.4066
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 9-13 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Aprepitant is metabolized primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19. Seven metabolites of aprepitant, which are only weakly active, have been identified in human plasma.

Rute Eliminasi

Aprepitant is eliminated primarily by metabolism; aprepitant is not renally excreted. Aprepitant is excreted in the milk of rats. It is not known whether this drug is excreted in human milk.

Interaksi Makanan

2 Data
  • 1. Exercise caution with grapefruit products. Grapefruit inhibits the CYP3A4 metabolism of fosaprepitant, which may increase its serum concentration.
  • 2. Exercise caution with St. John's Wort. This herb induces the CYP3A4 metabolism of fosaprepitant and may reduce its serum concentration.

Interaksi Obat

566 Data
Lomitapide The metabolism of Lomitapide can be decreased when combined with Fosaprepitant.
Aripiprazole The metabolism of Aripiprazole can be increased when combined with Fosaprepitant.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be increased when combined with Fosaprepitant.
Phenytoin The metabolism of Fosaprepitant can be increased when combined with Phenytoin.
Fosphenytoin The metabolism of Fosaprepitant can be increased when combined with Fosphenytoin.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Fosaprepitant.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Fosaprepitant.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Fosaprepitant.
Colchicine The metabolism of Colchicine can be decreased when combined with Fosaprepitant.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Fosaprepitant.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Fosaprepitant.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Fosaprepitant.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Fosaprepitant.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Fosaprepitant.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Fosaprepitant.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Fosaprepitant.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Fosaprepitant.
Ifosfamide The metabolism of Ifosfamide can be increased when combined with Fosaprepitant.
Perampanel The metabolism of Perampanel can be increased when combined with Fosaprepitant.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Fosaprepitant.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Fosaprepitant.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Fosaprepitant.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Fosaprepitant.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Fosaprepitant.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Fosaprepitant.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Fosaprepitant.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Fosaprepitant.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Fosaprepitant.
Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Fosaprepitant.
Bexarotene The metabolism of Fosaprepitant can be increased when combined with Bexarotene.
Bosentan The metabolism of Fosaprepitant can be increased when combined with Bosentan.
Nafcillin The metabolism of Fosaprepitant can be increased when combined with Nafcillin.
Modafinil The metabolism of Fosaprepitant can be increased when combined with Modafinil.
Etravirine The metabolism of Fosaprepitant can be increased when combined with Etravirine.
Avasimibe The metabolism of Fosaprepitant can be increased when combined with Avasimibe.
Echinacea The metabolism of Fosaprepitant can be increased when combined with Echinacea.
Dexamethasone acetate The metabolism of Fosaprepitant can be increased when combined with Dexamethasone acetate.
Pitolisant The serum concentration of Fosaprepitant can be decreased when it is combined with Pitolisant.
Segesterone acetate The metabolism of Segesterone acetate can be increased when combined with Fosaprepitant.
Metreleptin The metabolism of Fosaprepitant can be increased when combined with Metreleptin.
Octylphenoxy polyethoxyethanol The metabolism of Octylphenoxy polyethoxyethanol can be increased when combined with Fosaprepitant.
Trestolone The metabolism of Trestolone can be increased when combined with Fosaprepitant.
Cloprostenol The metabolism of Cloprostenol can be increased when combined with Fosaprepitant.
Gossypol The metabolism of Gossypol can be increased when combined with Fosaprepitant.
Ormeloxifene The metabolism of Ormeloxifene can be increased when combined with Fosaprepitant.
Norgestrienone The metabolism of Norgestrienone can be increased when combined with Fosaprepitant.
Norethindrone enanthate The metabolism of Norethindrone enanthate can be increased when combined with Fosaprepitant.
Etonogestrel The metabolism of Etonogestrel can be increased when combined with Fosaprepitant.
Desogestrel The metabolism of Desogestrel can be increased when combined with Fosaprepitant.
Megestrol acetate The metabolism of Megestrol acetate can be increased when combined with Fosaprepitant.
Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Fosaprepitant.
Ethynodiol diacetate The metabolism of Ethynodiol diacetate can be increased when combined with Fosaprepitant.
Ethinylestradiol The metabolism of Ethinylestradiol can be increased when combined with Fosaprepitant.
Mestranol The metabolism of Mestranol can be increased when combined with Fosaprepitant.
Estrone sulfate The metabolism of Estrone sulfate can be increased when combined with Fosaprepitant.
Norelgestromin The metabolism of Norelgestromin can be increased when combined with Fosaprepitant.
Gestodene The metabolism of Gestodene can be increased when combined with Fosaprepitant.
Hydroxyprogesterone caproate The metabolism of Hydroxyprogesterone caproate can be increased when combined with Fosaprepitant.
Ulipristal The metabolism of Ulipristal can be increased when combined with Fosaprepitant.
Dienogest The metabolism of Dienogest can be increased when combined with Fosaprepitant.
Norethynodrel The metabolism of Norethynodrel can be increased when combined with Fosaprepitant.
Norgestrel The metabolism of Norgestrel can be increased when combined with Fosaprepitant.
Gestrinone The metabolism of Gestrinone can be increased when combined with Fosaprepitant.
Nomegestrol The metabolism of Nomegestrol can be increased when combined with Fosaprepitant.
Lynestrenol The metabolism of Lynestrenol can be increased when combined with Fosaprepitant.
Chlormadinone The metabolism of Chlormadinone can be increased when combined with Fosaprepitant.
Quingestanol The metabolism of Quingestanol can be increased when combined with Fosaprepitant.
Demegestone The metabolism of Demegestone can be increased when combined with Fosaprepitant.
Etynodiol The metabolism of Etynodiol can be increased when combined with Fosaprepitant.
Nomegestrol acetate The metabolism of Nomegestrol acetate can be increased when combined with Fosaprepitant.
Estradiol The metabolism of Estradiol can be increased when combined with Fosaprepitant.
Diethylstilbestrol The metabolism of Diethylstilbestrol can be increased when combined with Fosaprepitant.
Progesterone The metabolism of Progesterone can be increased when combined with Fosaprepitant.
Medroxyprogesterone acetate The metabolism of Medroxyprogesterone acetate can be increased when combined with Fosaprepitant.
Norethisterone The metabolism of Norethisterone can be increased when combined with Fosaprepitant.
Mifepristone The metabolism of Mifepristone can be increased when combined with Fosaprepitant.
Norgestimate The metabolism of Norgestimate can be increased when combined with Fosaprepitant.
Drospirenone The metabolism of Drospirenone can be increased when combined with Fosaprepitant.
Cyproterone acetate The metabolism of Cyproterone acetate can be increased when combined with Fosaprepitant.
Testosterone enanthate The metabolism of Testosterone enanthate can be increased when combined with Fosaprepitant.
Estradiol benzoate The metabolism of Estradiol benzoate can be increased when combined with Fosaprepitant.
Estradiol cypionate The metabolism of Estradiol cypionate can be increased when combined with Fosaprepitant.
Estradiol valerate The metabolism of Estradiol valerate can be increased when combined with Fosaprepitant.
Rifabutin The metabolism of Fosaprepitant can be increased when combined with Rifabutin.
Felbamate The metabolism of Fosaprepitant can be increased when combined with Felbamate.
Genistein The metabolism of Fosaprepitant can be increased when combined with Genistein.
Oritavancin The metabolism of Fosaprepitant can be increased when combined with Oritavancin.
Armodafinil The metabolism of Fosaprepitant can be increased when combined with Armodafinil.
Glycerol phenylbutyrate The metabolism of Fosaprepitant can be increased when combined with Glycerol phenylbutyrate.
Eslicarbazepine acetate The metabolism of Fosaprepitant can be increased when combined with Eslicarbazepine acetate.
Lesinurad The metabolism of Fosaprepitant can be increased when combined with Lesinurad.
Asunaprevir The metabolism of Fosaprepitant can be increased when combined with Asunaprevir.
Sarilumab The metabolism of Fosaprepitant can be increased when combined with Sarilumab.
Esketamine The metabolism of Fosaprepitant can be increased when combined with Esketamine.
Rufinamide The metabolism of Fosaprepitant can be increased when combined with Rufinamide.
Calcitriol The metabolism of Fosaprepitant can be increased when combined with Calcitriol.
Vitamin E The metabolism of Fosaprepitant can be increased when combined with Vitamin E.
Flunisolide The metabolism of Fosaprepitant can be increased when combined with Flunisolide.
Troglitazone The metabolism of Fosaprepitant can be increased when combined with Troglitazone.
Butalbital The metabolism of Fosaprepitant can be increased when combined with Butalbital.

Target Protein

Substance-P receptor TACR1

Referensi & Sumber

Synthesis reference: Navin Ganesh Bhatt, Nikhil Rasiklal Trivedi, Mahesh Khedekar, Sukumar Sinha, Mubeen Ahmed Khan, Ramjilal Yadav, "FOSAPREPITANT DIMEGLUMINE INTERMEDIATE, NEUTRAL FOSAPREPITANT, AND AMORPHOUS FOSAPREPITANT DIMEGLUMINE AND PROCESSES FOR THEIR PREPARATIONS." U.S. Patent US20110130366, issued June 02, 2011.

Contoh Produk & Brand

Produk: 59 • International brands: 0
Produk
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  • Emend IV
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  • Focinvez
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Sekuens Gen/Protein (FASTA)

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