Nilvadipine

DB06712

small molecule approved investigational

Deskripsi

Nilvadipine is a calcium channel blocker (CCB) for the treatment of hypertension.

Struktur Molekul 2D

Berat 385.3707
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Makanan

1 Data
  • 1. Take with or without food.

Interaksi Obat

1762 Data
Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Nilvadipine is combined with Duloxetine.
Levodopa The risk or severity of hypotension and orthostatic hypotension can be increased when Nilvadipine is combined with Levodopa.
Risperidone Nilvadipine may increase the hypotensive activities of Risperidone.
Ceritinib Nilvadipine may increase the bradycardic activities of Ceritinib.
Ruxolitinib Ruxolitinib may increase the bradycardic activities of Nilvadipine.
Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Nilvadipine.
Amifostine Nilvadipine may increase the hypotensive activities of Amifostine.
Diazoxide Diazoxide may increase the hypotensive activities of Nilvadipine.
Methylphenidate Methylphenidate may decrease the antihypertensive activities of Nilvadipine.
Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Nilvadipine.
Obinutuzumab Nilvadipine may increase the hypotensive activities of Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the hypotensive activities of Nilvadipine.
Rituximab Nilvadipine may increase the hypotensive activities of Rituximab.
Desmopressin Desmopressin may decrease the antihypertensive activities of Nilvadipine.
Isoetharine Isoetharine may decrease the antihypertensive activities of Nilvadipine.
Etomidate Etomidate may decrease the antihypertensive activities of Nilvadipine.
Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Nilvadipine.
Norepinephrine Norepinephrine may decrease the antihypertensive activities of Nilvadipine.
Phenylpropanolamine Phenylpropanolamine may decrease the antihypertensive activities of Nilvadipine.
Doxapram Doxapram may decrease the antihypertensive activities of Nilvadipine.
Metaraminol Metaraminol may decrease the antihypertensive activities of Nilvadipine.
Sumatriptan Sumatriptan may decrease the antihypertensive activities of Nilvadipine.
Methoxamine Methoxamine may decrease the antihypertensive activities of Nilvadipine.
Orciprenaline Orciprenaline may decrease the antihypertensive activities of Nilvadipine.
Phenmetrazine Phenmetrazine may decrease the antihypertensive activities of Nilvadipine.
Dobutamine Dobutamine may decrease the antihypertensive activities of Nilvadipine.
Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Nilvadipine.
Ritodrine Ritodrine may decrease the antihypertensive activities of Nilvadipine.
Bitolterol Bitolterol may decrease the antihypertensive activities of Nilvadipine.
Diethylpropion Diethylpropion may decrease the antihypertensive activities of Nilvadipine.
Naratriptan Naratriptan may decrease the antihypertensive activities of Nilvadipine.
Rizatriptan Rizatriptan may decrease the antihypertensive activities of Nilvadipine.
Dopamine Dopamine may decrease the antihypertensive activities of Nilvadipine.
Frovatriptan Frovatriptan may decrease the antihypertensive activities of Nilvadipine.
Isoprenaline Isoprenaline may decrease the antihypertensive activities of Nilvadipine.
Arbutamine Arbutamine may decrease the antihypertensive activities of Nilvadipine.
Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Nilvadipine.
Fenoterol Fenoterol may decrease the antihypertensive activities of Nilvadipine.
Pirbuterol Pirbuterol may decrease the antihypertensive activities of Nilvadipine.
Ephedra sinica root Ephedra sinica root may decrease the antihypertensive activities of Nilvadipine.
Ephedrine Ephedrine may decrease the antihypertensive activities of Nilvadipine.
Mephentermine Mephentermine may decrease the antihypertensive activities of Nilvadipine.
Procaterol Procaterol may decrease the antihypertensive activities of Nilvadipine.
Clenbuterol Clenbuterol may decrease the antihypertensive activities of Nilvadipine.
Bambuterol Bambuterol may decrease the antihypertensive activities of Nilvadipine.
MMDA MMDA may decrease the antihypertensive activities of Nilvadipine.
Midomafetamine Midomafetamine may decrease the antihypertensive activities of Nilvadipine.
2,5-Dimethoxy-4-ethylamphetamine 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Nilvadipine.
4-Methoxyamphetamine 4-Methoxyamphetamine may decrease the antihypertensive activities of Nilvadipine.
4-Bromo-2,5-dimethoxyamphetamine 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Nilvadipine.
Tenamfetamine Tenamfetamine may decrease the antihypertensive activities of Nilvadipine.
Chlorphentermine Chlorphentermine may decrease the antihypertensive activities of Nilvadipine.
Dextroamphetamine Dextroamphetamine may decrease the antihypertensive activities of Nilvadipine.
Metamfetamine Metamfetamine may decrease the antihypertensive activities of Nilvadipine.
Phendimetrazine Phendimetrazine may decrease the antihypertensive activities of Nilvadipine.
Epicaptopril Epicaptopril may decrease the antihypertensive activities of Nilvadipine.
1-benzylimidazole 1-benzylimidazole may decrease the antihypertensive activities of Nilvadipine.
Amineptine Amineptine may decrease the antihypertensive activities of Nilvadipine.
Amibegron Amibegron may decrease the antihypertensive activities of Nilvadipine.
Naluzotan Naluzotan may decrease the antihypertensive activities of Nilvadipine.
Solabegron Solabegron may decrease the antihypertensive activities of Nilvadipine.
Droxidopa Droxidopa may decrease the antihypertensive activities of Nilvadipine.
Esmirtazapine Esmirtazapine may decrease the antihypertensive activities of Nilvadipine.
Nitrous oxide Nitrous oxide may decrease the antihypertensive activities of Nilvadipine.
Isometheptene Isometheptene may decrease the antihypertensive activities of Nilvadipine.
Levonordefrin Levonordefrin may decrease the antihypertensive activities of Nilvadipine.
Naphazoline Naphazoline may decrease the antihypertensive activities of Nilvadipine.
Tetryzoline Tetryzoline may decrease the antihypertensive activities of Nilvadipine.
Cinitapride Cinitapride may decrease the antihypertensive activities of Nilvadipine.
Tyramine Tyramine may decrease the antihypertensive activities of Nilvadipine.
Adrafinil Adrafinil may decrease the antihypertensive activities of Nilvadipine.
Ifenprodil Ifenprodil may decrease the antihypertensive activities of Nilvadipine.
Hexoprenaline Hexoprenaline may decrease the antihypertensive activities of Nilvadipine.
Etilefrine Etilefrine may decrease the antihypertensive activities of Nilvadipine.
Dimetacrine Dimetacrine may decrease the antihypertensive activities of Nilvadipine.
Cirazoline Cirazoline may decrease the antihypertensive activities of Nilvadipine.
Synephrine Synephrine may decrease the antihypertensive activities of Nilvadipine.
Moxisylyte Moxisylyte may decrease the antihypertensive activities of Nilvadipine.
Oxaprotiline Oxaprotiline may decrease the antihypertensive activities of Nilvadipine.
Iofetamine I-123 Iofetamine I-123 may decrease the antihypertensive activities of Nilvadipine.
Racepinephrine Racepinephrine may decrease the antihypertensive activities of Nilvadipine.
DL-Methylephedrine DL-Methylephedrine may decrease the antihypertensive activities of Nilvadipine.
Amitraz Amitraz may decrease the antihypertensive activities of Nilvadipine.
Medetomidine Medetomidine may decrease the antihypertensive activities of Nilvadipine.
Xylazine Xylazine may decrease the antihypertensive activities of Nilvadipine.
Atipamezole Atipamezole may decrease the antihypertensive activities of Nilvadipine.
Ractopamine Ractopamine may decrease the antihypertensive activities of Nilvadipine.
Romifidine Romifidine may decrease the antihypertensive activities of Nilvadipine.
Detomidine Detomidine may decrease the antihypertensive activities of Nilvadipine.
Etafedrine Etafedrine may decrease the antihypertensive activities of Nilvadipine.
Tetrahydrocannabivarin Tetrahydrocannabivarin may decrease the antihypertensive activities of Nilvadipine.
PF-00610355 PF-00610355 may decrease the antihypertensive activities of Nilvadipine.
Ritobegron Ritobegron may decrease the antihypertensive activities of Nilvadipine.
Abediterol Abediterol may decrease the antihypertensive activities of Nilvadipine.
Tulobuterol Tulobuterol may decrease the antihypertensive activities of Nilvadipine.
Dopexamine Dopexamine may decrease the antihypertensive activities of Nilvadipine.
Piclozotan Piclozotan may decrease the antihypertensive activities of Nilvadipine.
Idazoxan Idazoxan may decrease the antihypertensive activities of Nilvadipine.
Higenamine Higenamine may decrease the antihypertensive activities of Nilvadipine.
Reproterol Reproterol may decrease the antihypertensive activities of Nilvadipine.

Target Protein

Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C
Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1
Voltage-dependent L-type calcium channel subunit beta-2 CACNB2
Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D
Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S
Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3
Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H
Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I
Voltage gated L-type calcium channel CACNA1C
Voltage-dependent T-type calcium channel CACNA1G

Referensi & Sumber

Synthesis reference: Minoru Nakano, Toshinobu Uemura, Shinichi Morizane, Kiyoshi Okuda, Keiko Nakata, "Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine." U.S. Patent US5340591, issued March, 1985.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Nivadil

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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