Peringatan Keamanan

Gadolinium-based contrast agents increase the risk for nephrogenic systemic fibrosis (NSF) in patients with acute or chronic severe renal insufficiency (glomerular filtration rate < 30 mL/min/1.73m²).

Gadofosveset trisodium

DB06705

small molecule approved

Deskripsi

Gadofosveset trisodium is an intravenous contrast agent used with magnetic resonance angiography(MRA), which is a non-invasive way of imaging blood vessels. The agent allows for the vascular system to be imaged more clearly by the MRA. In this way, gadofosveset trisodium is used to help diagnose certain disorders of the heart and blood vessels.

Struktur Molekul 2D

Berat 1003.85
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 18.5 hours
Volume Distribusi 48 ± 16 mL/kg
Klirens (Clearance) 6.57 ± 0.97 mL/h/kg following the administration of 0.03 mmol/kg.

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Gadofosveset does not undergo measurable metabolism.

Rute Eliminasi

Gadofosveset is eliminated primarily in the urine with approximately 83.5% of an injected dose excreted in the urine over 14 days. Ninety-four percent (94%) of urinary excretion occurs in the first 72 hours. A small portion of gadofosveset dose is recovered in feces (approximately 4.7%).

Interaksi Obat

727 Data
Cyclosporine Cyclosporine may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Latamoxef Latamoxef may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Nimesulide Nimesulide may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Benoxaprofen Benoxaprofen may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Metamizole Metamizole may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Zomepirac Zomepirac may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Ceftobiprole Ceftobiprole may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Cimicoxib Cimicoxib may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Lornoxicam Lornoxicam may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Aceclofenac Aceclofenac may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.

Target Protein

Albumin ALB

Referensi & Sumber

Artikel (PubMed)
  • PMID: 23515949
    Raman FS, Nacif MS, Cater G, Gai N, Jones J, Li D, Sibley CT, Liu S, Bluemke DA: 3.0-T whole-heart coronary magnetic resonance angiography: comparison of gadobenate dimeglumine and gadofosveset trisodium. Int J Cardiovasc Imaging. 2013 Jun;29(5):1085-94. doi: 10.1007/s10554-013-0192-z. Epub 2013 Mar 21.
  • PMID: 22660207
    Hrdina L, Kocher M, Herman M, Cerna M, Kozak J, Tudos Z, Mahathmakanthi S, Langova K: Comparison of the quality of lower limb magnetic resonance angiographies performed with different paramagnetic contrast agents in relation to body mass index and ejection fraction. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2012 Jun;156(2):164-70. doi: 10.5507/bp.2011.058.
  • PMID: 22536125
    Thouet T, Schnackenburg B, Kokocinski T, Fleck E, Nagel E, Kelle S: Visualization of chronic myocardial infarction using the intravascular contrast agent MS-325 (gadofosveset) in patients. ScientificWorldJournal. 2012;2012:236401. doi: 10.1100/2012/236401. Epub 2012 Mar 12.
  • PMID: 22488745
    Milot L, Haider M, Foster L, McGregor C, Law C: Gadofosveset trisodium in the investigation of focal liver lesions in noncirrhotic liver: Early experience. J Magn Reson Imaging. 2012 Sep;36(3):738-42. doi: 10.1002/jmri.23650. Epub 2012 Apr 5.
  • PMID: 19222207
    Caravan P: Protein-targeted gadolinium-based magnetic resonance imaging (MRI) contrast agents: design and mechanism of action. Acc Chem Res. 2009 Jul 21;42(7):851-62. doi: 10.1021/ar800220p.

Contoh Produk & Brand

Produk: 13 • International brands: 0
Produk
  • Ablavar
    Injection, solution • 244 mg/1mL • Intravenous • US • Approved
  • Ablavar
    Solution • 244 mg / mL • Intravenous • Canada • Approved
  • Ablavar
    Injection, solution • 0.25 mmol/ml • Intravenous • EU
  • Ablavar
    Injection, solution • 0.25 mmol/ml • Intravenous • EU
  • Ablavar
    Injection, solution • 0.25 mmol/ml • Intravenous • EU
  • Ablavar
    Injection, solution • 0.25 mmol/ml • Intravenous • EU
  • Ablavar
    Injection, solution • 0.25 mmol/ml • Intravenous • EU
  • Ablavar
    Injection, solution • 0.25 mmol/ml • Intravenous • EU
Menampilkan 8 dari 13 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul