Aprotinin is a protein-based drug that is also known as bovine pancreatic trypsin inhibitor (BPTI). Since it demonstrates the capacity to slow fibrinolysis, it has been employed to reduce bleeding during complex surgery such as heart and liver surgery. For this use, it is typically administered by injection. The goal of using of aprotinin was subsequently to minimize end-organ damage resulting from hypotension due to blood loss in surgery and to reduce the necessity for blood transfusions during surgery. Nevertheless, the drug was formally withdrawn worldwide in May of 2008 after studies confirmed that its use enhanced the risk of complications or death. The substance is consequently made available only for very restricted research use.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Alteplase | The therapeutic efficacy of Alteplase can be decreased when used in combination with Aprotinin. |
| Urokinase | The therapeutic efficacy of Urokinase can be decreased when used in combination with Aprotinin. |
| Reteplase | The therapeutic efficacy of Reteplase can be decreased when used in combination with Aprotinin. |
| Anistreplase | The therapeutic efficacy of Anistreplase can be decreased when used in combination with Aprotinin. |
| Tenecteplase | The therapeutic efficacy of Tenecteplase can be decreased when used in combination with Aprotinin. |
| Drotrecogin alfa | The therapeutic efficacy of Drotrecogin alfa can be decreased when used in combination with Aprotinin. |
| Streptokinase | The therapeutic efficacy of Streptokinase can be decreased when used in combination with Aprotinin. |
| Dicoumarol | The therapeutic efficacy of Dicoumarol can be decreased when used in combination with Aprotinin. |
| Desmoteplase | The therapeutic efficacy of Desmoteplase can be decreased when used in combination with Aprotinin. |
| Defibrotide | The therapeutic efficacy of Defibrotide can be decreased when used in combination with Aprotinin. |
| Ancrod | The therapeutic efficacy of Ancrod can be decreased when used in combination with Aprotinin. |
| Sulodexide | The therapeutic efficacy of Sulodexide can be decreased when used in combination with Aprotinin. |
| Astaxanthin | The therapeutic efficacy of Astaxanthin can be decreased when used in combination with Aprotinin. |
| Amediplase | The therapeutic efficacy of Amediplase can be decreased when used in combination with Aprotinin. |
| Protein C | The therapeutic efficacy of Protein C can be decreased when used in combination with Aprotinin. |
| Monteplase | The therapeutic efficacy of Monteplase can be decreased when used in combination with Aprotinin. |
| Brinase | The therapeutic efficacy of Brinase can be decreased when used in combination with Aprotinin. |
| Saruplase | The therapeutic efficacy of Saruplase can be decreased when used in combination with Aprotinin. |
| Ramipril | Aprotinin may decrease the antihypertensive activities of Ramipril. |
| Fosinopril | Aprotinin may decrease the antihypertensive activities of Fosinopril. |
| Trandolapril | Aprotinin may decrease the antihypertensive activities of Trandolapril. |
| Benazepril | Aprotinin may decrease the antihypertensive activities of Benazepril. |
| Enalapril | Aprotinin may decrease the antihypertensive activities of Enalapril. |
| Moexipril | Aprotinin may decrease the antihypertensive activities of Moexipril. |
| Lisinopril | Aprotinin may decrease the antihypertensive activities of Lisinopril. |
| Perindopril | Aprotinin may decrease the antihypertensive activities of Perindopril. |
| Quinapril | Aprotinin may decrease the antihypertensive activities of Quinapril. |
| Omapatrilat | Aprotinin may decrease the antihypertensive activities of Omapatrilat. |
| Rescinnamine | Aprotinin may decrease the antihypertensive activities of Rescinnamine. |
| Captopril | Aprotinin may decrease the antihypertensive activities of Captopril. |
| Cilazapril | Aprotinin may decrease the antihypertensive activities of Cilazapril. |
| Spirapril | Aprotinin may decrease the antihypertensive activities of Spirapril. |
| Temocapril | Aprotinin may decrease the antihypertensive activities of Temocapril. |
| Enalaprilat | Aprotinin may decrease the antihypertensive activities of Enalaprilat. |
| Imidapril | Aprotinin may decrease the antihypertensive activities of Imidapril. |
| Zofenopril | Aprotinin may decrease the antihypertensive activities of Zofenopril. |
| Delapril | Aprotinin may decrease the antihypertensive activities of Delapril. |
| Benazeprilat | Aprotinin may decrease the antihypertensive activities of Benazeprilat. |
| Fosinoprilat | Aprotinin may decrease the antihypertensive activities of Fosinoprilat. |
| Ramiprilat | Aprotinin may decrease the antihypertensive activities of Ramiprilat. |
| Trandolaprilat | Aprotinin may decrease the antihypertensive activities of Trandolaprilat. |
| Moexiprilat | Aprotinin may decrease the antihypertensive activities of Moexiprilat. |
| Perindoprilat | Aprotinin may decrease the antihypertensive activities of Perindoprilat. |
| Quinaprilat | Aprotinin may decrease the antihypertensive activities of Quinaprilat. |
| Cilazaprilat | Aprotinin may decrease the antihypertensive activities of Cilazaprilat. |
| Dipyridamole | The therapeutic efficacy of Aprotinin can be decreased when used in combination with Dipyridamole. |
| Ephedrine | Aprotinin may increase the neuromuscular blocking activities of Ephedrine. |
| Bambuterol | Aprotinin may increase the neuromuscular blocking activities of Bambuterol. |
| Clevidipine | Aprotinin may increase the neuromuscular blocking activities of Clevidipine. |
| Sar9, Met (O2)11-Substance P | Aprotinin may increase the neuromuscular blocking activities of Sar9, Met (O2)11-Substance P. |
| Mirabegron | Aprotinin may increase the neuromuscular blocking activities of Mirabegron. |
| Moxisylyte | Aprotinin may increase the neuromuscular blocking activities of Moxisylyte. |
| Propacetamol | Aprotinin may increase the neuromuscular blocking activities of Propacetamol. |
| Procaine | Aprotinin may increase the neuromuscular blocking activities of Procaine. |
| Cocaine | Aprotinin may increase the neuromuscular blocking activities of Cocaine. |
| Trimethaphan | Aprotinin may increase the neuromuscular blocking activities of Trimethaphan. |
| Doxacurium | Aprotinin may increase the neuromuscular blocking activities of Doxacurium. |
| Chloroprocaine | Aprotinin may increase the neuromuscular blocking activities of Chloroprocaine. |
| Tubocurarine | Aprotinin may increase the neuromuscular blocking activities of Tubocurarine. |
| Aclidinium | Aprotinin may increase the neuromuscular blocking activities of Aclidinium. |
| Butyrylthiocholine | Aprotinin may increase the neuromuscular blocking activities of Butyrylthiocholine. |
| Oxybuprocaine | Aprotinin may increase the neuromuscular blocking activities of Oxybuprocaine. |
| Benzonatate | Aprotinin may increase the neuromuscular blocking activities of Benzonatate. |
| Succinylcholine | The metabolism of Succinylcholine can be decreased when combined with Aprotinin. |
| Alpha-1-proteinase inhibitor | Alpha-1-proteinase inhibitor may increase the thrombogenic activities of Aprotinin. |
| Menadione | Menadione may increase the thrombogenic activities of Aprotinin. |
| Tranexamic acid | Tranexamic acid may increase the thrombogenic activities of Aprotinin. |
| Aminocaproic acid | Aminocaproic acid may increase the thrombogenic activities of Aprotinin. |
| Hydrogen peroxide | Aprotinin may increase the thrombogenic activities of Hydrogen peroxide. |
| Aminomethylbenzoic acid | Aprotinin may increase the thrombogenic activities of Aminomethylbenzoic acid. |
| Camostat | Aprotinin may increase the thrombogenic activities of Camostat. |
| Menadione bisulfite | Aprotinin may increase the thrombogenic activities of Menadione bisulfite. |
| Tramadol | The therapeutic efficacy of Tramadol can be decreased when used in combination with Aprotinin. |
| Trospium | The therapeutic efficacy of Trospium can be decreased when used in combination with Aprotinin. |
| Oxyphenonium | The therapeutic efficacy of Oxyphenonium can be decreased when used in combination with Aprotinin. |
| Butabarbital | The therapeutic efficacy of Butabarbital can be decreased when used in combination with Aprotinin. |
| Butalbital | The therapeutic efficacy of Butalbital can be decreased when used in combination with Aprotinin. |
| Benzatropine | The therapeutic efficacy of Benzatropine can be decreased when used in combination with Aprotinin. |
| Ziprasidone | The therapeutic efficacy of Ziprasidone can be decreased when used in combination with Aprotinin. |
| Disopyramide | The therapeutic efficacy of Disopyramide can be decreased when used in combination with Aprotinin. |
| Talbutal | The therapeutic efficacy of Talbutal can be decreased when used in combination with Aprotinin. |
| Pentobarbital | The therapeutic efficacy of Pentobarbital can be decreased when used in combination with Aprotinin. |
| Amitriptyline | The therapeutic efficacy of Amitriptyline can be decreased when used in combination with Aprotinin. |
| Ipratropium | The therapeutic efficacy of Ipratropium can be decreased when used in combination with Aprotinin. |
| Methadone | The therapeutic efficacy of Methadone can be decreased when used in combination with Aprotinin. |
| Olanzapine | The therapeutic efficacy of Olanzapine can be decreased when used in combination with Aprotinin. |
| Metixene | The therapeutic efficacy of Metixene can be decreased when used in combination with Aprotinin. |
| Terfenadine | The therapeutic efficacy of Terfenadine can be decreased when used in combination with Aprotinin. |
| Buclizine | The therapeutic efficacy of Buclizine can be decreased when used in combination with Aprotinin. |
| Clozapine | The therapeutic efficacy of Clozapine can be decreased when used in combination with Aprotinin. |
| Doxylamine | The therapeutic efficacy of Doxylamine can be decreased when used in combination with Aprotinin. |
| Trihexyphenidyl | The therapeutic efficacy of Trihexyphenidyl can be decreased when used in combination with Aprotinin. |
| Oxyphencyclimine | The therapeutic efficacy of Oxyphencyclimine can be decreased when used in combination with Aprotinin. |
| Procyclidine | The therapeutic efficacy of Procyclidine can be decreased when used in combination with Aprotinin. |
| Profenamine | The therapeutic efficacy of Profenamine can be decreased when used in combination with Aprotinin. |
| Secobarbital | The therapeutic efficacy of Secobarbital can be decreased when used in combination with Aprotinin. |
| Promazine | The therapeutic efficacy of Promazine can be decreased when used in combination with Aprotinin. |
| Hyoscyamine | The therapeutic efficacy of Hyoscyamine can be decreased when used in combination with Aprotinin. |
| Cyproheptadine | The therapeutic efficacy of Cyproheptadine can be decreased when used in combination with Aprotinin. |
| Imipramine | The therapeutic efficacy of Imipramine can be decreased when used in combination with Aprotinin. |