Esmirtazapine

DB06678

small molecule investigational

Deskripsi

Esmirtazapine, known by the standardized identifier SCH 900265, was under development by Organon to treat insomnia and vasomotor symptoms associated with menopause. Esmirtazapine is the (S)-(+)-enantiomer of mirtazapine and possesses similar overall pharmacology. This includes inverse agonist activity of H1 and 5-HT2 receptors and antagonism of ?2-adrenergic receptors. Merck has terminated its internal clinical development program for esmirtazapine as of March 2010.

Struktur Molekul 2D

Berat 265.36
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 10 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1258 Data
Valsartan Esmirtazapine may decrease the antihypertensive activities of Valsartan.
Ramipril Esmirtazapine may decrease the antihypertensive activities of Ramipril.
Remikiren Esmirtazapine may decrease the antihypertensive activities of Remikiren.
Torasemide Esmirtazapine may decrease the antihypertensive activities of Torasemide.
Guanadrel Esmirtazapine may decrease the antihypertensive activities of Guanadrel.
Isradipine Esmirtazapine may decrease the antihypertensive activities of Isradipine.
Olmesartan Esmirtazapine may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Esmirtazapine may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Esmirtazapine may decrease the antihypertensive activities of Nitroprusside.
Minoxidil Esmirtazapine may decrease the antihypertensive activities of Minoxidil.
Treprostinil Esmirtazapine may decrease the antihypertensive activities of Treprostinil.
Nimodipine Esmirtazapine may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Esmirtazapine may decrease the antihypertensive activities of Nisoldipine.
Bendroflumethiazide Esmirtazapine may decrease the antihypertensive activities of Bendroflumethiazide.
Prazosin Esmirtazapine may decrease the antihypertensive activities of Prazosin.
Fosinopril Esmirtazapine may decrease the antihypertensive activities of Fosinopril.
Trandolapril Esmirtazapine may decrease the antihypertensive activities of Trandolapril.
Metolazone Esmirtazapine may decrease the antihypertensive activities of Metolazone.
Benazepril Esmirtazapine may decrease the antihypertensive activities of Benazepril.
Bosentan Esmirtazapine may decrease the antihypertensive activities of Bosentan.
Enalapril Esmirtazapine may decrease the antihypertensive activities of Enalapril.
Cyclothiazide Esmirtazapine may decrease the antihypertensive activities of Cyclothiazide.
Bisoprolol Esmirtazapine may decrease the antihypertensive activities of Bisoprolol.
Candoxatril Esmirtazapine may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Esmirtazapine may decrease the antihypertensive activities of Mecamylamine.
Losartan Esmirtazapine may decrease the antihypertensive activities of Losartan.
Moexipril Esmirtazapine may decrease the antihypertensive activities of Moexipril.
Eplerenone Esmirtazapine may decrease the antihypertensive activities of Eplerenone.
Lisinopril Esmirtazapine may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Esmirtazapine may decrease the antihypertensive activities of Nitroglycerin.
Hydroflumethiazide Esmirtazapine may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Esmirtazapine may decrease the antihypertensive activities of Cryptenamine.
Perindopril Esmirtazapine may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Esmirtazapine may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Esmirtazapine may decrease the antihypertensive activities of Fenoldopam.
Indapamide Esmirtazapine may decrease the antihypertensive activities of Indapamide.
Tadalafil Esmirtazapine may decrease the antihypertensive activities of Tadalafil.
Eprosartan Esmirtazapine may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Esmirtazapine may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Esmirtazapine may decrease the antihypertensive activities of Quinapril.
Telmisartan Esmirtazapine may decrease the antihypertensive activities of Telmisartan.
Methyldopa Esmirtazapine may decrease the antihypertensive activities of Methyldopa.
Hydrochlorothiazide Esmirtazapine may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Esmirtazapine may decrease the antihypertensive activities of Trichlormethiazide.
Irbesartan Esmirtazapine may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Esmirtazapine may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Esmirtazapine may decrease the antihypertensive activities of Deserpidine.
Pentolinium Esmirtazapine may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Esmirtazapine may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Esmirtazapine may decrease the antihypertensive activities of Diazoxide.
Bretylium Esmirtazapine may decrease the antihypertensive activities of Bretylium.
Terazosin Esmirtazapine may decrease the antihypertensive activities of Terazosin.
Guanethidine Esmirtazapine may decrease the antihypertensive activities of Guanethidine.
Epoprostenol Esmirtazapine may decrease the antihypertensive activities of Epoprostenol.
Hydralazine Esmirtazapine may decrease the antihypertensive activities of Hydralazine.
Polythiazide Esmirtazapine may decrease the antihypertensive activities of Polythiazide.
Cilazapril Esmirtazapine may decrease the antihypertensive activities of Cilazapril.
Saprisartan Esmirtazapine may decrease the antihypertensive activities of Saprisartan.
Spirapril Esmirtazapine may decrease the antihypertensive activities of Spirapril.
Dexpropranolol Esmirtazapine may decrease the antihypertensive activities of Dexpropranolol.
Tienilic acid Esmirtazapine may decrease the antihypertensive activities of Tienilic acid.
Sitaxentan Esmirtazapine may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Esmirtazapine may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Esmirtazapine may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Esmirtazapine may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Esmirtazapine may decrease the antihypertensive activities of Pinacidil.
Temocapril Esmirtazapine may decrease the antihypertensive activities of Temocapril.
Riociguat Esmirtazapine may decrease the antihypertensive activities of Riociguat.
Macitentan Esmirtazapine may decrease the antihypertensive activities of Macitentan.
Aliskiren Esmirtazapine may decrease the antihypertensive activities of Aliskiren.
Trimazosin Esmirtazapine may decrease the antihypertensive activities of Trimazosin.
Nicorandil Esmirtazapine may decrease the antihypertensive activities of Nicorandil.
Efonidipine Esmirtazapine may decrease the antihypertensive activities of Efonidipine.
Lacidipine Esmirtazapine may decrease the antihypertensive activities of Lacidipine.
Niguldipine Esmirtazapine may decrease the antihypertensive activities of Niguldipine.
Rauwolfia serpentina root Esmirtazapine may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Esmirtazapine may decrease the antihypertensive activities of Enalaprilat.
Selexipag Esmirtazapine may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Esmirtazapine may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Esmirtazapine may decrease the antihypertensive activities of Imidapril.
BQ-123 Esmirtazapine may decrease the antihypertensive activities of BQ-123.
Cicletanine Esmirtazapine may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Esmirtazapine may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Esmirtazapine may decrease the antihypertensive activities of Zofenopril.
Guanoxan Esmirtazapine may decrease the antihypertensive activities of Guanoxan.
Delapril Esmirtazapine may decrease the antihypertensive activities of Delapril.
Vincamine Esmirtazapine may decrease the antihypertensive activities of Vincamine.
Linsidomine Esmirtazapine may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Esmirtazapine may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Esmirtazapine may decrease the antihypertensive activities of Tolonidine.
Endralazine Esmirtazapine may decrease the antihypertensive activities of Endralazine.
Cadralazine Esmirtazapine may decrease the antihypertensive activities of Cadralazine.
Cyclopenthiazide Esmirtazapine may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Esmirtazapine may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Esmirtazapine may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Esmirtazapine may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Esmirtazapine may decrease the antihypertensive activities of Guanoclor.
Muzolimine Esmirtazapine may decrease the antihypertensive activities of Muzolimine.
Xipamide Esmirtazapine may decrease the antihypertensive activities of Xipamide.
Candesartan Esmirtazapine may decrease the antihypertensive activities of Candesartan.

Target Protein

Histamine H1 receptor HRH1
5-hydroxytryptamine receptor 2 HTR2A
Alpha-2 adrenergic receptors ADRA2A

Referensi & Sumber

Artikel (PubMed)
  • PMID: 18673166
    Teegarden BR, Al Shamma H, Xiong Y: 5-HT(2A) inverse-agonists for the treatment of insomnia. Curr Top Med Chem. 2008;8(11):969-76.
  • PMID: 19775194
    Lewis V: Undertreatment of menopausal symptoms and novel options for comprehensive management. Curr Med Res Opin. 2009 Nov;25(11):2689-98. doi: 10.1185/03007990903240519.

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