Vicriviroc

DB06652

small molecule investigational

Deskripsi

Vicriviroc, also known as SCH 417690 and SCH-D, is currently in clinical trials for the management of HIV-1. This pyrimidine based drug inhibits the interaction of HIV-1 with CCR5, preventing viral entry into cells. This drug was developed by Schering-Plough.

Struktur Molekul 2D

Berat 533.6288
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Metabolised primarily by the CYP3A4 system

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

537 Data
Fluvoxamine The metabolism of Vicriviroc can be decreased when combined with Fluvoxamine.
Troglitazone The metabolism of Vicriviroc can be decreased when combined with Troglitazone.
Fluoxetine The metabolism of Vicriviroc can be decreased when combined with Fluoxetine.
Nabilone The metabolism of Vicriviroc can be decreased when combined with Nabilone.
Imatinib The metabolism of Vicriviroc can be decreased when combined with Imatinib.
Mifepristone The metabolism of Vicriviroc can be decreased when combined with Mifepristone.
Felbamate The metabolism of Vicriviroc can be decreased when combined with Felbamate.
Sulfinpyrazone The metabolism of Vicriviroc can be decreased when combined with Sulfinpyrazone.
Iproniazid The metabolism of Vicriviroc can be decreased when combined with Iproniazid.
Medical Cannabis The metabolism of Vicriviroc can be decreased when combined with Medical Cannabis.
Valproic acid The metabolism of Vicriviroc can be decreased when combined with Valproic acid.
Quinidine The metabolism of Vicriviroc can be decreased when combined with Quinidine.
Dabrafenib The serum concentration of Vicriviroc can be decreased when it is combined with Dabrafenib.
Fluconazole The metabolism of Vicriviroc can be decreased when combined with Fluconazole.
Floxuridine The metabolism of Vicriviroc can be decreased when combined with Floxuridine.
Nicardipine The metabolism of Vicriviroc can be decreased when combined with Nicardipine.
Miconazole The metabolism of Vicriviroc can be decreased when combined with Miconazole.
Gemfibrozil The metabolism of Vicriviroc can be decreased when combined with Gemfibrozil.
Sulfaphenazole The metabolism of Vicriviroc can be decreased when combined with Sulfaphenazole.
Pitolisant The serum concentration of Vicriviroc can be decreased when it is combined with Pitolisant.
Metreleptin The metabolism of Vicriviroc can be increased when combined with Metreleptin.
Diltiazem The metabolism of Vicriviroc can be decreased when combined with Diltiazem.
Cimetidine The metabolism of Vicriviroc can be decreased when combined with Cimetidine.
Ciprofloxacin The metabolism of Vicriviroc can be decreased when combined with Ciprofloxacin.
Isavuconazole The metabolism of Vicriviroc can be decreased when combined with Isavuconazole.
Verapamil The metabolism of Vicriviroc can be decreased when combined with Verapamil.
Erythromycin The serum concentration of Vicriviroc can be increased when it is combined with Erythromycin.
Gestodene The metabolism of Vicriviroc can be decreased when combined with Gestodene.
Nabiximols The metabolism of Vicriviroc can be decreased when combined with Nabiximols.
Chloramphenicol The metabolism of Vicriviroc can be decreased when combined with Chloramphenicol.
Fluticasone propionate The metabolism of Vicriviroc can be decreased when combined with Fluticasone propionate.
Aprepitant The metabolism of Vicriviroc can be decreased when combined with Aprepitant.
Mibefradil The metabolism of Vicriviroc can be decreased when combined with Mibefradil.
Fluticasone furoate The metabolism of Fluticasone furoate can be decreased when combined with Vicriviroc.
Letermovir The metabolism of Vicriviroc can be decreased when combined with Letermovir.
Fluticasone The metabolism of Vicriviroc can be decreased when combined with Fluticasone.
Curcumin sulfate The metabolism of Vicriviroc can be decreased when combined with Curcumin sulfate.
Methylene blue The metabolism of Vicriviroc can be decreased when combined with Methylene blue.
Clofazimine The metabolism of Vicriviroc can be decreased when combined with Clofazimine.
Pralsetinib The metabolism of Vicriviroc can be decreased when combined with Pralsetinib.
Levoketoconazole The metabolism of Vicriviroc can be decreased when combined with Levoketoconazole.
Acalabrutinib The metabolism of Vicriviroc can be decreased when combined with Acalabrutinib.
Osilodrostat The metabolism of Vicriviroc can be decreased when combined with Osilodrostat.
Icotinib The metabolism of Vicriviroc can be increased when combined with Icotinib.
Modafinil The metabolism of Vicriviroc can be increased when combined with Modafinil.
Budesonide The metabolism of Vicriviroc can be increased when combined with Budesonide.
Dexamethasone acetate The metabolism of Vicriviroc can be increased when combined with Dexamethasone acetate.
Reserpine The metabolism of Vicriviroc can be increased when combined with Reserpine.
Beclomethasone dipropionate The metabolism of Vicriviroc can be increased when combined with Beclomethasone dipropionate.
Daunorubicin The metabolism of Vicriviroc can be increased when combined with Daunorubicin.
Thalidomide The metabolism of Vicriviroc can be increased when combined with Thalidomide.
Armodafinil The metabolism of Vicriviroc can be increased when combined with Armodafinil.
Oxcarbazepine The metabolism of Vicriviroc can be increased when combined with Oxcarbazepine.
Triamcinolone The metabolism of Vicriviroc can be increased when combined with Triamcinolone.
Cortisone acetate The metabolism of Vicriviroc can be increased when combined with Cortisone acetate.
Paramethasone The metabolism of Vicriviroc can be increased when combined with Paramethasone.
Fluprednidene The metabolism of Vicriviroc can be increased when combined with Fluprednidene.
Meprednisone The metabolism of Vicriviroc can be increased when combined with Meprednisone.
Dexamethasone isonicotinate The metabolism of Vicriviroc can be increased when combined with Dexamethasone isonicotinate.
Cortivazol The metabolism of Vicriviroc can be increased when combined with Cortivazol.
Prednylidene The metabolism of Vicriviroc can be increased when combined with Prednylidene.
Cloprednol The metabolism of Vicriviroc can be increased when combined with Cloprednol.
Mometasone furoate The metabolism of Vicriviroc can be increased when combined with Mometasone furoate.
Prednisolone phosphate The metabolism of Vicriviroc can be increased when combined with Prednisolone phosphate.
Prednisolone hemisuccinate The metabolism of Vicriviroc can be increased when combined with Prednisolone hemisuccinate.
Prednisone acetate The metabolism of Vicriviroc can be increased when combined with Prednisone acetate.
Clocortolone acetate The metabolism of Vicriviroc can be increased when combined with Clocortolone acetate.
Melengestrol acetate The metabolism of Vicriviroc can be increased when combined with Melengestrol acetate.
Betamethasone phosphate The metabolism of Vicriviroc can be increased when combined with Betamethasone phosphate.
Cortisone The metabolism of Vicriviroc can be increased when combined with Cortisone.
Clobetasol propionate The metabolism of Vicriviroc can be increased when combined with Clobetasol propionate.
Fluocinonide The metabolism of Vicriviroc can be increased when combined with Fluocinonide.
Mometasone The metabolism of Vicriviroc can be increased when combined with Mometasone.
Fluocortolone The metabolism of Vicriviroc can be increased when combined with Fluocortolone.
Difluocortolone The metabolism of Vicriviroc can be increased when combined with Difluocortolone.
Betamethasone The metabolism of Vicriviroc can be increased when combined with Betamethasone.
Pentamidine The metabolism of Vicriviroc can be decreased when combined with Pentamidine.
Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Vicriviroc.
Dutasteride The metabolism of Vicriviroc can be decreased when combined with Dutasteride.
Azimilide The metabolism of Vicriviroc can be decreased when combined with Azimilide.
Sildenafil The metabolism of Vicriviroc can be decreased when combined with Sildenafil.
Dapsone The metabolism of Vicriviroc can be decreased when combined with Dapsone.
Lidocaine The metabolism of Vicriviroc can be decreased when combined with Lidocaine.
Levonorgestrel The metabolism of Vicriviroc can be decreased when combined with Levonorgestrel.
Nisoldipine The metabolism of Vicriviroc can be decreased when combined with Nisoldipine.
Alprazolam The metabolism of Vicriviroc can be decreased when combined with Alprazolam.
Quinine The metabolism of Vicriviroc can be decreased when combined with Quinine.
Buspirone The metabolism of Vicriviroc can be decreased when combined with Buspirone.
Oxycodone The metabolism of Vicriviroc can be decreased when combined with Oxycodone.
Flutamide The metabolism of Vicriviroc can be decreased when combined with Flutamide.
Dextromethorphan The metabolism of Vicriviroc can be decreased when combined with Dextromethorphan.
Lercanidipine The metabolism of Vicriviroc can be decreased when combined with Lercanidipine.
Propranolol The metabolism of Vicriviroc can be decreased when combined with Propranolol.
Chloroquine The metabolism of Vicriviroc can be decreased when combined with Chloroquine.
Testosterone The metabolism of Vicriviroc can be decreased when combined with Testosterone.
Trazodone The metabolism of Vicriviroc can be decreased when combined with Trazodone.
Midazolam The metabolism of Vicriviroc can be decreased when combined with Midazolam.
Mycophenolate mofetil The metabolism of Vicriviroc can be decreased when combined with Mycophenolate mofetil.
Eplerenone The metabolism of Vicriviroc can be decreased when combined with Eplerenone.
Norethisterone The metabolism of Vicriviroc can be decreased when combined with Norethisterone.

Target Protein

C-C chemokine receptor type 5 CCR5

Referensi & Sumber

Artikel (PubMed)
  • PMID: 16306033
    Idemyor V: Human immunodeficiency virus (HIV) entry inhibitors (CCR5 specific blockers) in development: are they the next novel therapies? HIV Clin Trials. 2005 Sep-Oct;6(5):272-7.
  • PMID: 17933722
    Emmelkamp JM, Rockstroh JK: CCR5 antagonists: comparison of efficacy, side effects, pharmacokinetics and interactions--review of the literature. Eur J Med Res. 2007 Oct 15;12(9):409-17.
  • PMID: 17827338
    Ghosal A, Ramanathan R, Yuan Y, Hapangama N, Chowdhury SK, Kishnani NS, Alton KB: Identification of human liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist. Drug Metab Dispos. 2007 Dec;35(12):2186-95. Epub 2007 Sep 7.

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