Lexatumumab

DB06599

biotech investigational

Deskripsi

Lexatumumab is a fully humanized, high-affinity immunoglobulin G(1 lambda) monoclonal antibody (mAb).

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

372 Data
Diethylstilbestrol Diethylstilbestrol may increase the thrombogenic activities of Lexatumumab.
Chlorotrianisene Chlorotrianisene may increase the thrombogenic activities of Lexatumumab.
Conjugated estrogens Conjugated estrogens may increase the thrombogenic activities of Lexatumumab.
Estrone Estrone may increase the thrombogenic activities of Lexatumumab.
Estradiol Estradiol may increase the thrombogenic activities of Lexatumumab.
Dienestrol Dienestrol may increase the thrombogenic activities of Lexatumumab.
Ethinylestradiol Ethinylestradiol may increase the thrombogenic activities of Lexatumumab.
Mestranol Mestranol may increase the thrombogenic activities of Lexatumumab.
Estriol Estriol may increase the thrombogenic activities of Lexatumumab.
Estrone sulfate Estrone sulfate may increase the thrombogenic activities of Lexatumumab.
Quinestrol Quinestrol may increase the thrombogenic activities of Lexatumumab.
Hexestrol Hexestrol may increase the thrombogenic activities of Lexatumumab.
Tibolone Tibolone may increase the thrombogenic activities of Lexatumumab.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may increase the thrombogenic activities of Lexatumumab.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may increase the thrombogenic activities of Lexatumumab.
Polyestradiol phosphate Polyestradiol phosphate may increase the thrombogenic activities of Lexatumumab.
Esterified estrogens Esterified estrogens may increase the thrombogenic activities of Lexatumumab.
Zeranol Zeranol may increase the thrombogenic activities of Lexatumumab.
Equol Equol may increase the thrombogenic activities of Lexatumumab.
Promestriene Promestriene may increase the thrombogenic activities of Lexatumumab.
Methallenestril Methallenestril may increase the thrombogenic activities of Lexatumumab.
Epimestrol Epimestrol may increase the thrombogenic activities of Lexatumumab.
Moxestrol Moxestrol may increase the thrombogenic activities of Lexatumumab.
Estradiol acetate Estradiol acetate may increase the thrombogenic activities of Lexatumumab.
Estradiol benzoate Estradiol benzoate may increase the thrombogenic activities of Lexatumumab.
Estradiol cypionate Estradiol cypionate may increase the thrombogenic activities of Lexatumumab.
Estradiol valerate Estradiol valerate may increase the thrombogenic activities of Lexatumumab.
Biochanin A Biochanin A may increase the thrombogenic activities of Lexatumumab.
Formononetin Formononetin may increase the thrombogenic activities of Lexatumumab.
Estetrol Estetrol may increase the thrombogenic activities of Lexatumumab.
Cetuximab The risk or severity of adverse effects can be increased when Cetuximab is combined with Lexatumumab.
Human immunoglobulin G The risk or severity of adverse effects can be increased when Human immunoglobulin G is combined with Lexatumumab.
Omalizumab The risk or severity of adverse effects can be increased when Omalizumab is combined with Lexatumumab.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Lexatumumab.
Abciximab The risk or severity of adverse effects can be increased when Abciximab is combined with Lexatumumab.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Lexatumumab.
Indium In-111 satumomab pendetide The risk or severity of adverse effects can be increased when Indium In-111 satumomab pendetide is combined with Lexatumumab.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Lexatumumab.
Trastuzumab The risk or severity of adverse effects can be increased when Trastuzumab is combined with Lexatumumab.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Lexatumumab.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Lexatumumab.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Lexatumumab.
Digoxin Immune Fab (Ovine) The risk or severity of adverse effects can be increased when Digoxin Immune Fab (Ovine) is combined with Lexatumumab.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Lexatumumab.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Lexatumumab.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Lexatumumab.
Capromab pendetide The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Lexatumumab.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Lexatumumab.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Lexatumumab.
Natalizumab The risk or severity of adverse effects can be increased when Natalizumab is combined with Lexatumumab.
Palivizumab The risk or severity of adverse effects can be increased when Palivizumab is combined with Lexatumumab.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Lexatumumab.
Bevacizumab The risk or severity of adverse effects can be increased when Bevacizumab is combined with Lexatumumab.
Technetium Tc-99m arcitumomab The risk or severity of adverse effects can be increased when Technetium Tc-99m arcitumomab is combined with Lexatumumab.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with Lexatumumab.
Panitumumab The risk or severity of adverse effects can be increased when Panitumumab is combined with Lexatumumab.
Ranibizumab The risk or severity of adverse effects can be increased when Ranibizumab is combined with Lexatumumab.
Galiximab The risk or severity of adverse effects can be increased when Galiximab is combined with Lexatumumab.
Pexelizumab The risk or severity of adverse effects can be increased when Pexelizumab is combined with Lexatumumab.
Afelimomab The risk or severity of adverse effects can be increased when Afelimomab is combined with Lexatumumab.
Epratuzumab The risk or severity of adverse effects can be increased when Epratuzumab is combined with Lexatumumab.
Bectumomab The risk or severity of adverse effects can be increased when Bectumomab is combined with Lexatumumab.
Oregovomab The risk or severity of adverse effects can be increased when Oregovomab is combined with Lexatumumab.
IGN311 The risk or severity of adverse effects can be increased when IGN311 is combined with Lexatumumab.
Adecatumumab The risk or severity of adverse effects can be increased when Adecatumumab is combined with Lexatumumab.
Labetuzumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Lexatumumab.
Matuzumab The risk or severity of adverse effects can be increased when Matuzumab is combined with Lexatumumab.
Fontolizumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Lexatumumab.
Bavituximab The risk or severity of adverse effects can be increased when Bavituximab is combined with Lexatumumab.
CR002 The risk or severity of adverse effects can be increased when CR002 is combined with Lexatumumab.
Rozrolimupab The risk or severity of adverse effects can be increased when Rozrolimupab is combined with Lexatumumab.
Girentuximab The risk or severity of adverse effects can be increased when Girentuximab is combined with Lexatumumab.
Obiltoxaximab The risk or severity of adverse effects can be increased when Obiltoxaximab is combined with Lexatumumab.
XTL-001 The risk or severity of adverse effects can be increased when XTL-001 is combined with Lexatumumab.
NAV 1800 The risk or severity of adverse effects can be increased when NAV 1800 is combined with Lexatumumab.
Briakinumab The risk or severity of adverse effects can be increased when Briakinumab is combined with Lexatumumab.
Otelixizumab The risk or severity of adverse effects can be increased when Otelixizumab is combined with Lexatumumab.
AMG 108 The risk or severity of adverse effects can be increased when AMG 108 is combined with Lexatumumab.
Iratumumab The risk or severity of adverse effects can be increased when Iratumumab is combined with Lexatumumab.
Enokizumab The risk or severity of adverse effects can be increased when Enokizumab is combined with Lexatumumab.
Ramucirumab The risk or severity of adverse effects can be increased when Ramucirumab is combined with Lexatumumab.
Farletuzumab The risk or severity of adverse effects can be increased when Farletuzumab is combined with Lexatumumab.
Veltuzumab The risk or severity of adverse effects can be increased when Veltuzumab is combined with Lexatumumab.
Ustekinumab The risk or severity of adverse effects can be increased when Ustekinumab is combined with Lexatumumab.
Trastuzumab emtansine The risk or severity of adverse effects can be increased when Trastuzumab emtansine is combined with Lexatumumab.
PRO-542 The risk or severity of adverse effects can be increased when PRO-542 is combined with Lexatumumab.
TNX-901 The risk or severity of adverse effects can be increased when TNX-901 is combined with Lexatumumab.
Inotuzumab ozogamicin The risk or severity of adverse effects can be increased when Inotuzumab ozogamicin is combined with Lexatumumab.
RI 624 The risk or severity of adverse effects can be increased when RI 624 is combined with Lexatumumab.
Stamulumab The risk or severity of adverse effects can be increased when MYO-029 is combined with Lexatumumab.
CT-011 The risk or severity of adverse effects can be increased when CT-011 is combined with Lexatumumab.
Leronlimab The risk or severity of adverse effects can be increased when Leronlimab is combined with Lexatumumab.
Glembatumumab vedotin The risk or severity of adverse effects can be increased when Glembatumumab vedotin is combined with Lexatumumab.
Olaratumab The risk or severity of adverse effects can be increased when Olaratumab is combined with Lexatumumab.
IPH 2101 The risk or severity of adverse effects can be increased when IPH 2101 is combined with Lexatumumab.
TB-402 The risk or severity of adverse effects can be increased when TB-402 is combined with Lexatumumab.
Caplacizumab The risk or severity of adverse effects can be increased when Caplacizumab is combined with Lexatumumab.
IMC-1C11 The risk or severity of adverse effects can be increased when IMC-1C11 is combined with Lexatumumab.
Eldelumab The risk or severity of adverse effects can be increased when Eldelumab is combined with Lexatumumab.
Lumiliximab The risk or severity of adverse effects can be increased when Lumiliximab is combined with Lexatumumab.

Target Protein

Tumor necrosis factor receptor superfamily member 10B TNFRSF10B

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17671142
    Maddipatla S, Hernandez-Ilizaliturri FJ, Knight J, Czuczman MS: Augmented antitumor activity against B-cell lymphoma by a combination of monoclonal antibodies targeting TRAIL-R1 and CD20. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4556-64.
  • PMID: 18056199
    Zhang X, Li W, Olumi AF: Low-dose 12-O-tetradecanoylphorbol-13-acetate enhances tumor necrosis factor related apoptosis-inducing ligand induced apoptosis in prostate cancer cells. Clin Cancer Res. 2007 Dec 1;13(23):7181-90.

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