Muraglitazar

DB06510

small molecule investigational

Deskripsi

Muraglitazar (Bristol-Myers Squibb/Merck) is a new agent under investigation for the treatment of patients with type 2 diabetes. It belongs to a novel class of drugs that target the peroxisome proliferator-activated receptors, both alpha and gamma subtypes. In addition to improvements in blood glucose and hemoglobin A1c (HbA1c), muraglitazar treatment is associated with a substantial reduction in triglycerides (TGs), an increase in HDL-C, and a modest decrease in LDL-C levels.

Struktur Molekul 2D

Berat 516.55
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

251 Data
Mifepristone The serum concentration of Muraglitazar can be increased when it is combined with Mifepristone.
Nelfinavir The metabolism of Muraglitazar can be increased when combined with Nelfinavir.
Desogestrel The metabolism of Muraglitazar can be increased when combined with Desogestrel.
Zidovudine The metabolism of Muraglitazar can be increased when combined with Zidovudine.
Lamotrigine The metabolism of Muraglitazar can be increased when combined with Lamotrigine.
Carbamazepine The metabolism of Muraglitazar can be increased when combined with Carbamazepine.
Efavirenz The metabolism of Muraglitazar can be increased when combined with Efavirenz.
Tipranavir The metabolism of Muraglitazar can be increased when combined with Tipranavir.
Ethinylestradiol The metabolism of Muraglitazar can be increased when combined with Ethinylestradiol.
Testosterone propionate The metabolism of Muraglitazar can be increased when combined with Testosterone propionate.
Primidone The metabolism of Muraglitazar can be increased when combined with Primidone.
Secobarbital The metabolism of Muraglitazar can be increased when combined with Secobarbital.
Rifampin The metabolism of Muraglitazar can be increased when combined with Rifampicin.
Phenobarbital The metabolism of Muraglitazar can be increased when combined with Phenobarbital.
Bexarotene The metabolism of Muraglitazar can be decreased when combined with Bexarotene.
Diltiazem The metabolism of Muraglitazar can be decreased when combined with Diltiazem.
Levothyroxine The metabolism of Muraglitazar can be decreased when combined with Levothyroxine.
Loratadine The metabolism of Muraglitazar can be decreased when combined with Loratadine.
Quinine The metabolism of Muraglitazar can be decreased when combined with Quinine.
Medroxyprogesterone acetate The metabolism of Muraglitazar can be decreased when combined with Medroxyprogesterone acetate.
Nicardipine The metabolism of Muraglitazar can be decreased when combined with Nicardipine.
Tamoxifen The metabolism of Muraglitazar can be decreased when combined with Tamoxifen.
Irbesartan The metabolism of Muraglitazar can be decreased when combined with Irbesartan.
Oxybutynin The metabolism of Muraglitazar can be decreased when combined with Oxybutynin.
Fluvastatin The metabolism of Muraglitazar can be decreased when combined with Fluvastatin.
Pioglitazone The metabolism of Muraglitazar can be decreased when combined with Pioglitazone.
Saquinavir The metabolism of Muraglitazar can be decreased when combined with Saquinavir.
Genistein The metabolism of Muraglitazar can be decreased when combined with Genistein.
Topiroxostat The metabolism of Muraglitazar can be decreased when combined with Topiroxostat.
Abiraterone The metabolism of Muraglitazar can be decreased when combined with Abiraterone.
Teriflunomide The metabolism of Muraglitazar can be decreased when combined with Teriflunomide.
Enzalutamide The metabolism of Muraglitazar can be decreased when combined with Enzalutamide.
Trimethoprim The metabolism of Muraglitazar can be decreased when combined with Trimethoprim.
Ritonavir The metabolism of Muraglitazar can be decreased when combined with Ritonavir.
Fluticasone propionate The metabolism of Muraglitazar can be decreased when combined with Fluticasone propionate.
Clopidogrel The metabolism of Muraglitazar can be decreased when combined with Clopidogrel.
Candesartan cilexetil The metabolism of Muraglitazar can be decreased when combined with Candesartan cilexetil.
Salmeterol The metabolism of Muraglitazar can be decreased when combined with Salmeterol.
Felodipine The metabolism of Muraglitazar can be decreased when combined with Felodipine.
Gemfibrozil The metabolism of Muraglitazar can be decreased when combined with Gemfibrozil.
Fluticasone The metabolism of Muraglitazar can be decreased when combined with Fluticasone.
Mometasone furoate The metabolism of Muraglitazar can be decreased when combined with Mometasone furoate.
Adenine The metabolism of Muraglitazar can be decreased when combined with Adenine.
Indinavir The metabolism of Muraglitazar can be decreased when combined with Indinavir.
Valproic acid The metabolism of Muraglitazar can be decreased when combined with Valproic acid.
Amitriptyline The metabolism of Muraglitazar can be decreased when combined with Amitriptyline.
Indomethacin The metabolism of Muraglitazar can be decreased when combined with Indomethacin.
Flurbiprofen The metabolism of Muraglitazar can be decreased when combined with Flurbiprofen.
Propofol The metabolism of Muraglitazar can be decreased when combined with Propofol.
Ketoconazole The metabolism of Muraglitazar can be decreased when combined with Ketoconazole.
Probenecid The metabolism of Muraglitazar can be decreased when combined with Probenecid.
Atazanavir The metabolism of Muraglitazar can be decreased when combined with Atazanavir.
Flunitrazepam The metabolism of Muraglitazar can be decreased when combined with Flunitrazepam.
Deferasirox The metabolism of Muraglitazar can be decreased when combined with Deferasirox.
Nilotinib The metabolism of Muraglitazar can be decreased when combined with Nilotinib.
Eltrombopag The metabolism of Muraglitazar can be decreased when combined with Eltrombopag.
Regorafenib The metabolism of Muraglitazar can be decreased when combined with Regorafenib.
Dasabuvir The metabolism of Muraglitazar can be decreased when combined with Dasabuvir.
Sodium aurothiomalate The metabolism of Muraglitazar can be decreased when combined with Sodium aurothiomalate.
Ombitasvir The metabolism of Muraglitazar can be decreased when combined with Ombitasvir.
Paritaprevir The metabolism of Muraglitazar can be decreased when combined with Paritaprevir.
Silibinin The metabolism of Muraglitazar can be decreased when combined with Silibinin.
Dacomitinib The metabolism of Muraglitazar can be decreased when combined with Dacomitinib.
Fostamatinib The metabolism of Muraglitazar can be decreased when combined with Fostamatinib.
Pibrentasvir The metabolism of Muraglitazar can be decreased when combined with Pibrentasvir.
Glecaprevir The metabolism of Muraglitazar can be decreased when combined with Glecaprevir.
Pexidartinib The metabolism of Muraglitazar can be decreased when combined with Pexidartinib.
Pyrimethamine The metabolism of Muraglitazar can be decreased when combined with Pyrimethamine.
Ticlopidine The metabolism of Muraglitazar can be decreased when combined with Ticlopidine.
Cimetidine The metabolism of Muraglitazar can be decreased when combined with Cimetidine.
Rofecoxib The metabolism of Muraglitazar can be decreased when combined with Rofecoxib.
Quinidine The metabolism of Muraglitazar can be decreased when combined with Quinidine.
Ketoprofen The metabolism of Muraglitazar can be decreased when combined with Ketoprofen.
Fenofibrate The metabolism of Muraglitazar can be decreased when combined with Fenofibrate.
Tegaserod The metabolism of Muraglitazar can be decreased when combined with Tegaserod.
Cabozantinib The metabolism of Muraglitazar can be decreased when combined with Cabozantinib.
Diethylstilbestrol The metabolism of Muraglitazar can be decreased when combined with Diethylstilbestrol.
Terfenadine The metabolism of Muraglitazar can be decreased when combined with Terfenadine.
Cerivastatin The metabolism of Muraglitazar can be decreased when combined with Cerivastatin.
Raloxifene The metabolism of Muraglitazar can be decreased when combined with Raloxifene.
Simvastatin The metabolism of Muraglitazar can be decreased when combined with Simvastatin.
Nilutamide The metabolism of Muraglitazar can be decreased when combined with Nilutamide.
Metronidazole The metabolism of Muraglitazar can be decreased when combined with Metronidazole.
Bezafibrate The metabolism of Muraglitazar can be decreased when combined with Bezafibrate.
Quercetin The metabolism of Muraglitazar can be decreased when combined with Quercetin.
Licofelone The metabolism of Muraglitazar can be decreased when combined with Licofelone.
Nilvadipine The metabolism of Muraglitazar can be decreased when combined with Nilvadipine.
Sulfaphenazole The metabolism of Muraglitazar can be decreased when combined with Sulfaphenazole.
Vemurafenib The metabolism of Muraglitazar can be decreased when combined with Vemurafenib.
Lumacaftor The metabolism of Muraglitazar can be decreased when combined with Lumacaftor.
Isavuconazole The metabolism of Muraglitazar can be decreased when combined with Isavuconazole.
Alpelisib The metabolism of Muraglitazar can be decreased when combined with Alpelisib.
Letermovir The metabolism of Muraglitazar can be decreased when combined with Letermovir.
Triclabendazole The metabolism of Muraglitazar can be decreased when combined with Triclabendazole.
Candesartan The metabolism of Muraglitazar can be decreased when combined with Candesartan.
Favipiravir The metabolism of Muraglitazar can be decreased when combined with Favipiravir.
Methylene blue The metabolism of Muraglitazar can be decreased when combined with Methylene blue.
Mometasone The metabolism of Muraglitazar can be decreased when combined with Mometasone.
Pralsetinib The metabolism of Muraglitazar can be decreased when combined with Pralsetinib.
Miconazole The metabolism of Muraglitazar can be decreased when combined with Miconazole.

Target Protein

Peroxisome proliferator-activated receptor gamma PPARG
Peroxisome proliferator-activated receptor alpha PPARA

Referensi & Sumber

Belum ada data referensi/link/attachment untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field referensi.

Contoh Produk & Brand

Produk: 0 • International brands: 0
Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul