Clomethiazole is a well-established ?-aminobutyric acid (GABAA)-mimetic drug. It is a sedative and hypnotic that is widely used in treating and preventing symptoms of acute alcohol withdrawal. It is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant. It is also used for the management of agitation, restlessness, short-term insomnia and Parkinson's disease in the elderly.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Buprenorphine | Clomethiazole may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Clomethiazole. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Clomethiazole. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Clomethiazole. |
| Hydrocodone | Clomethiazole may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Clomethiazole. |
| Magnesium sulfate | The therapeutic efficacy of Clomethiazole can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Clomethiazole may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Clomethiazole may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Clomethiazole. |
| Mirtazapine | Clomethiazole may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Clomethiazole. |
| Orphenadrine | Clomethiazole may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Clomethiazole may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Clomethiazole. |
| Pramipexole | Clomethiazole may increase the sedative activities of Pramipexole. |
| Ropinirole | Clomethiazole may increase the sedative activities of Ropinirole. |
| Rotigotine | Clomethiazole may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Clomethiazole. |
| Suvorexant | Clomethiazole may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Clomethiazole. |
| Thalidomide | Clomethiazole may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Clomethiazole may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Mefloquine | The therapeutic efficacy of Clomethiazole can be decreased when used in combination with Mefloquine. |
| Mianserin | The therapeutic efficacy of Clomethiazole can be decreased when used in combination with Mianserin. |
| Orlistat | Orlistat can cause a decrease in the absorption of Clomethiazole resulting in a reduced serum concentration and potentially a decrease in efficacy. |
| Topotecan | Clomethiazole may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Clomethiazole. |
| Sodium oxybate | Clomethiazole may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Tetracosactide | The risk or severity of liver damage can be increased when Tetracosactide is combined with Clomethiazole. |
| Ethanol | Clomethiazole may increase the central nervous system depressant (CNS depressant) activities of Ethanol. |
| Azelastine | Clomethiazole may increase the central nervous system depressant (CNS depressant) activities of Azelastine. |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Clomethiazole. |
| Fluvoxamine | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Fluvoxamine. |
| Citalopram | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Citalopram. |
| Duloxetine | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Duloxetine. |
| Trazodone | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Trazodone. |
| Paroxetine | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Paroxetine. |
| Sibutramine | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Sibutramine. |
| Escitalopram | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Escitalopram. |
| Zimelidine | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Zimelidine. |
| Dapoxetine | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Dapoxetine. |
| Milnacipran | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Milnacipran. |
| Desvenlafaxine | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Desvenlafaxine. |
| Seproxetine | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Seproxetine. |
| Indalpine | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Indalpine. |
| Ritanserin | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Ritanserin. |
| Alaproclate | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Alaproclate. |
| Cyproheptadine | The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Clomethiazole. |
| Amoxapine | The risk or severity of CNS depression can be increased when Amoxapine is combined with Clomethiazole. |
| Propiomazine | The risk or severity of CNS depression can be increased when Propiomazine is combined with Clomethiazole. |
| Cocaine | The risk or severity of methemoglobinemia can be increased when Clomethiazole is combined with Cocaine. |
| Maprotiline | The risk or severity of CNS depression can be increased when Maprotiline is combined with Clomethiazole. |
| Pizotifen | The risk or severity of CNS depression can be increased when Pizotifen is combined with Clomethiazole. |
| Doxepin | The risk or severity of CNS depression can be increased when Doxepin is combined with Clomethiazole. |
| Quetiapine | The risk or severity of CNS depression can be increased when Quetiapine is combined with Clomethiazole. |
| Nortriptyline | The risk or severity of CNS depression can be increased when Nortriptyline is combined with Clomethiazole. |
| Amitriptyline | The risk or severity of CNS depression can be increased when Amitriptyline is combined with Clomethiazole. |
| Imipramine | The risk or severity of CNS depression can be increased when Imipramine is combined with Clomethiazole. |
| Desipramine | The risk or severity of CNS depression can be increased when Desipramine is combined with Clomethiazole. |
| Nicardipine | The metabolism of Clomethiazole can be decreased when combined with Nicardipine. |
| Quinidine | The therapeutic efficacy of Clomethiazole can be decreased when used in combination with Quinidine. |
| Zopiclone | The risk or severity of adverse effects can be increased when Clomethiazole is combined with Zopiclone. |
| Botulinum toxin type B | The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Clomethiazole. |
| Botulinum toxin type A | The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Clomethiazole. |
| Tryptophan | The risk or severity of CNS depression can be increased when Tryptophan is combined with Clomethiazole. |
| Baclofen | Baclofen may increase the central nervous system depressant (CNS depressant) activities of Clomethiazole. |
| Lorazepam | The risk or severity of CNS depression can be increased when Lorazepam is combined with Clomethiazole. |
| Ethchlorvynol | The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Clomethiazole. |
| Succinylcholine | The risk or severity of CNS depression can be increased when Succinylcholine is combined with Clomethiazole. |
| Reserpine | The risk or severity of CNS depression can be increased when Reserpine is combined with Clomethiazole. |
| Enflurane | The risk or severity of CNS depression can be increased when Enflurane is combined with Clomethiazole. |
| Temazepam | The risk or severity of CNS depression can be increased when Temazepam is combined with Clomethiazole. |
| Reboxetine | The risk or severity of CNS depression can be increased when Reboxetine is combined with Clomethiazole. |
| Butabarbital | The risk or severity of CNS depression can be increased when Butabarbital is combined with Clomethiazole. |
| Butalbital | The risk or severity of CNS depression can be increased when Butalbital is combined with Clomethiazole. |
| Cabergoline | The risk or severity of CNS depression can be increased when Cabergoline is combined with Clomethiazole. |
| Topiramate | The risk or severity of CNS depression can be increased when Topiramate is combined with Clomethiazole. |
| Clemastine | The risk or severity of CNS depression can be increased when Clemastine is combined with Clomethiazole. |
| Venlafaxine | The risk or severity of CNS depression can be increased when Venlafaxine is combined with Clomethiazole. |
| Etomidate | The risk or severity of CNS depression can be increased when Etomidate is combined with Clomethiazole. |
| Morphine | The risk or severity of CNS depression can be increased when Morphine is combined with Clomethiazole. |
| Talbutal | The risk or severity of CNS depression can be increased when Talbutal is combined with Clomethiazole. |
| Valproic acid | The risk or severity of CNS depression can be increased when Valproic acid is combined with Clomethiazole. |
| Zolmitriptan | The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Clomethiazole. |
| Codeine | The risk or severity of CNS depression can be increased when Codeine is combined with Clomethiazole. |
| Tolcapone | The risk or severity of CNS depression can be increased when Tolcapone is combined with Clomethiazole. |
| Hydromorphone | The risk or severity of CNS depression can be increased when Hydromorphone is combined with Clomethiazole. |
| Olanzapine | The risk or severity of CNS depression can be increased when Olanzapine is combined with Clomethiazole. |
| Cetirizine | The risk or severity of CNS depression can be increased when Cetirizine is combined with Clomethiazole. |
| Protriptyline | The risk or severity of CNS depression can be increased when Protriptyline is combined with Clomethiazole. |
| Trimethadione | The risk or severity of CNS depression can be increased when Trimethadione is combined with Clomethiazole. |
| Clobazam | The risk or severity of sedation, somnolence, and CNS depression can be increased when Clobazam is combined with Clomethiazole. |
| Chlorzoxazone | The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Clomethiazole. |
| Clozapine | The metabolism of Clomethiazole can be decreased when combined with Clozapine. |
| Meprobamate | The risk or severity of CNS depression can be increased when Meprobamate is combined with Clomethiazole. |
| Thiethylperazine | The risk or severity of CNS depression can be increased when Thiethylperazine is combined with Clomethiazole. |
| Palonosetron | The risk or severity of CNS depression can be increased when Palonosetron is combined with Clomethiazole. |
| Sulpiride | The risk or severity of CNS depression can be increased when Sulpiride is combined with Clomethiazole. |
| Dexbrompheniramine | The risk or severity of CNS depression can be increased when Dexbrompheniramine is combined with Clomethiazole. |