Squalamine

DB06461

small molecule investigational

Deskripsi

Struktur Molekul 2D

Berat 627.97
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

70 Data
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Squalamine.
Pamidronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Squalamine is combined with Pamidronic acid.
Zoledronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Squalamine is combined with Zoledronic acid.
Alendronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Squalamine is combined with Alendronic acid.
Ibandronate The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Squalamine is combined with Ibandronate.
Clodronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Squalamine is combined with Clodronic acid.
Risedronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Squalamine is combined with Risedronic acid.
Etidronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Squalamine is combined with Etidronic acid.
Tiludronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Squalamine is combined with Tiludronic acid.
Incadronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Squalamine is combined with Incadronic acid.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Squalamine.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Squalamine.
Dicoumarol The risk or severity of bleeding can be increased when Squalamine is combined with Dicoumarol.
Phenindione The risk or severity of bleeding can be increased when Squalamine is combined with Phenindione.
Warfarin The risk or severity of bleeding can be increased when Squalamine is combined with Warfarin.
Phenprocoumon The risk or severity of bleeding can be increased when Squalamine is combined with Phenprocoumon.
Acenocoumarol The risk or severity of bleeding can be increased when Squalamine is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of bleeding can be increased when Squalamine is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of bleeding can be increased when Squalamine is combined with Coumarin.
(R)-warfarin The risk or severity of bleeding can be increased when Squalamine is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of bleeding can be increased when Squalamine is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of bleeding can be increased when Squalamine is combined with Fluindione.
Clorindione The risk or severity of bleeding can be increased when Squalamine is combined with Clorindione.
Diphenadione The risk or severity of bleeding can be increased when Squalamine is combined with Diphenadione.
Tioclomarol The risk or severity of bleeding can be increased when Squalamine is combined with Tioclomarol.
(S)-Warfarin The risk or severity of bleeding can be increased when Squalamine is combined with (S)-Warfarin.
Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Squalamine.
Vibrio cholerae CVD 103-HgR strain live antigen The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Squalamine.
Estetrol The therapeutic efficacy of Estetrol can be decreased when used in combination with Squalamine.
Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Squalamine.
Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Squalamine.
Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Squalamine.
Methoxy polyethylene glycol-epoetin beta The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Squalamine.
Lidocaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Quinisocaine.
Cisatracurium Squalamine may increase the neuromuscular blocking activities of Cisatracurium.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Squalamine.
Ambroxol The risk or severity of methemoglobinemia can be increased when Squalamine is combined with Ambroxol.
Fecal microbiota The therapeutic efficacy of Fecal microbiota can be decreased when used in combination with Squalamine.
Etrasimod The risk or severity of immunosuppression can be increased when Squalamine is combined with Etrasimod.

Target Protein

Vascular endothelial growth factor C VEGFC
Vascular endothelial growth factor D VEGFD
Fibroblast growth factor 2 FGF2
Platelet-derived growth factor subunit A PDGFA
Vascular endothelial growth factor A, long form VEGFA
Vascular endothelial growth factor B VEGFB

Referensi & Sumber

Artikel (PubMed)
  • PMID: 11297269
    Williams JI, Weitman S, Gonzalez CM, Jundt CH, Marty J, Stringer SD, Holroyd KJ, Mclane MP, Chen Q, Zasloff M, Von Hoff DD: Squalamine treatment of human tumors in nu/nu mice enhances platinum-based chemotherapies. Clin Cancer Res. 2001 Mar;7(3):724-33.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Evizon

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul