Avasimibe

DB06442

small molecule investigational

Deskripsi

Struktur Molekul 2D

Berat 501.73
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

562 Data
Aripiprazole The metabolism of Aripiprazole can be increased when combined with Avasimibe.
Aripiprazole lauroxil The metabolism of Aripiprazole lauroxil can be increased when combined with Avasimibe.
Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Avasimibe.
Daclatasvir The metabolism of Daclatasvir can be increased when combined with Avasimibe.
Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Avasimibe.
Ifosfamide The metabolism of Ifosfamide can be increased when combined with Avasimibe.
Perampanel The metabolism of Perampanel can be increased when combined with Avasimibe.
Warfarin The metabolism of Warfarin can be increased when combined with Avasimibe.
Acenocoumarol The metabolism of Acenocoumarol can be increased when combined with Avasimibe.
(R)-warfarin The metabolism of (R)-warfarin can be increased when combined with Avasimibe.
R,S-Warfarin alcohol The metabolism of R,S-Warfarin alcohol can be increased when combined with Avasimibe.
S,R-Warfarin alcohol The metabolism of S,R-Warfarin alcohol can be increased when combined with Avasimibe.
(S)-Warfarin The metabolism of (S)-Warfarin can be increased when combined with Avasimibe.
Rolapitant The metabolism of Rolapitant can be increased when combined with Avasimibe.
Erlotinib The serum concentration of Erlotinib can be decreased when it is combined with Avasimibe.
Diethylstilbestrol The metabolism of Diethylstilbestrol can be increased when combined with Avasimibe.
Etonogestrel The metabolism of Etonogestrel can be increased when combined with Avasimibe.
Desogestrel The metabolism of Desogestrel can be increased when combined with Avasimibe.
Megestrol acetate The metabolism of Megestrol acetate can be increased when combined with Avasimibe.
Levonorgestrel The metabolism of Levonorgestrel can be increased when combined with Avasimibe.
Progesterone The metabolism of Progesterone can be increased when combined with Avasimibe.
Medroxyprogesterone acetate The metabolism of Medroxyprogesterone acetate can be increased when combined with Avasimibe.
Norethisterone The metabolism of Norethisterone can be increased when combined with Avasimibe.
Estradiol The metabolism of Estradiol can be increased when combined with Avasimibe.
Ethynodiol diacetate The metabolism of Ethynodiol diacetate can be increased when combined with Avasimibe.
Mifepristone The metabolism of Mifepristone can be increased when combined with Avasimibe.
Norgestimate The metabolism of Norgestimate can be increased when combined with Avasimibe.
Ethinylestradiol The metabolism of Ethinylestradiol can be increased when combined with Avasimibe.
Mestranol The metabolism of Mestranol can be increased when combined with Avasimibe.
Drospirenone The metabolism of Drospirenone can be increased when combined with Avasimibe.
Estrone sulfate The metabolism of Estrone sulfate can be increased when combined with Avasimibe.
Octylphenoxy polyethoxyethanol The metabolism of Octylphenoxy polyethoxyethanol can be increased when combined with Avasimibe.
Cyproterone acetate The metabolism of Cyproterone acetate can be increased when combined with Avasimibe.
Trestolone The metabolism of Trestolone can be increased when combined with Avasimibe.
Norelgestromin The metabolism of Norelgestromin can be increased when combined with Avasimibe.
Gestodene The metabolism of Gestodene can be increased when combined with Avasimibe.
Hydroxyprogesterone caproate The metabolism of Hydroxyprogesterone caproate can be increased when combined with Avasimibe.
Dienogest The metabolism of Dienogest can be increased when combined with Avasimibe.
Norethynodrel The metabolism of Norethynodrel can be increased when combined with Avasimibe.
Norgestrel The metabolism of Norgestrel can be increased when combined with Avasimibe.
Cloprostenol The metabolism of Cloprostenol can be increased when combined with Avasimibe.
Gestrinone The metabolism of Gestrinone can be increased when combined with Avasimibe.
Nomegestrol The metabolism of Nomegestrol can be increased when combined with Avasimibe.
Lynestrenol The metabolism of Lynestrenol can be increased when combined with Avasimibe.
Gossypol The metabolism of Gossypol can be increased when combined with Avasimibe.
Ormeloxifene The metabolism of Ormeloxifene can be increased when combined with Avasimibe.
Chlormadinone The metabolism of Chlormadinone can be increased when combined with Avasimibe.
Norgestrienone The metabolism of Norgestrienone can be increased when combined with Avasimibe.
Quingestanol The metabolism of Quingestanol can be increased when combined with Avasimibe.
Demegestone The metabolism of Demegestone can be increased when combined with Avasimibe.
Etynodiol The metabolism of Etynodiol can be increased when combined with Avasimibe.
Testosterone enanthate The metabolism of Testosterone enanthate can be increased when combined with Avasimibe.
Estradiol benzoate The metabolism of Estradiol benzoate can be increased when combined with Avasimibe.
Estradiol cypionate The metabolism of Estradiol cypionate can be increased when combined with Avasimibe.
Estradiol valerate The metabolism of Estradiol valerate can be increased when combined with Avasimibe.
Nomegestrol acetate The metabolism of Nomegestrol acetate can be increased when combined with Avasimibe.
Norethindrone enanthate The metabolism of Norethindrone enanthate can be increased when combined with Avasimibe.
Ulipristal The metabolism of Ulipristal can be increased when combined with Avasimibe.
Azithromycin The metabolism of Azithromycin can be increased when combined with Avasimibe.
Ziprasidone The metabolism of Ziprasidone can be increased when combined with Avasimibe.
Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Avasimibe.
Albendazole The metabolism of Albendazole can be increased when combined with Avasimibe.
Cephalexin The metabolism of Cephalexin can be increased when combined with Avasimibe.
Doxazosin The metabolism of Doxazosin can be increased when combined with Avasimibe.
Fenofibrate The metabolism of Fenofibrate can be increased when combined with Avasimibe.
Allylestrenol The metabolism of Allylestrenol can be increased when combined with Avasimibe.
Zuclopenthixol The metabolism of Zuclopenthixol can be increased when combined with Avasimibe.
Roflumilast The serum concentration of Roflumilast can be increased when it is combined with Avasimibe.
Linagliptin The metabolism of Linagliptin can be increased when combined with Avasimibe.
Vorapaxar The metabolism of Vorapaxar can be increased when combined with Avasimibe.
Suvorexant The metabolism of Suvorexant can be increased when combined with Avasimibe.
Tasimelteon The metabolism of Tasimelteon can be increased when combined with Avasimibe.
Nintedanib The metabolism of Nintedanib can be increased when combined with Avasimibe.
Tenofovir alafenamide The metabolism of Tenofovir alafenamide can be increased when combined with Avasimibe.
Dihydroergocornine The metabolism of Dihydroergocornine can be increased when combined with Avasimibe.
Duvelisib The metabolism of Duvelisib can be increased when combined with Avasimibe.
Gilteritinib The metabolism of Gilteritinib can be increased when combined with Avasimibe.
9-aminocamptothecin The metabolism of 9-aminocamptothecin can be increased when combined with Avasimibe.
Methylprednisone The metabolism of Methylprednisone can be increased when combined with Avasimibe.
Dihydroergocristine The metabolism of Dihydroergocristine can be increased when combined with Avasimibe.
Dihydroergocryptine The metabolism of Dihydroergocryptine can be increased when combined with Avasimibe.
Elexacaftor The metabolism of Elexacaftor can be increased when combined with Avasimibe.
Fosaprepitant The metabolism of Fosaprepitant can be increased when combined with Avasimibe.
Tazemetostat The metabolism of Tazemetostat can be increased when combined with Avasimibe.
Methysergide The metabolism of Methysergide can be increased when combined with Avasimibe.
Meperidine The metabolism of Meperidine can be increased when combined with Avasimibe.
Ebastine The metabolism of Ebastine can be increased when combined with Avasimibe.
Terfenadine The metabolism of Terfenadine can be increased when combined with Avasimibe.
Cisapride The metabolism of Cisapride can be increased when combined with Avasimibe.
Isavuconazole The metabolism of Isavuconazole can be increased when combined with Avasimibe.
Pretomanid The serum concentration of Pretomanid can be decreased when it is combined with Avasimibe.
Pimavanserin The metabolism of Pimavanserin can be increased when combined with Avasimibe.
Estetrol The metabolism of Estetrol can be increased when combined with Avasimibe.
Segesterone acetate The metabolism of Segesterone acetate can be increased when combined with Avasimibe.
Cyclosporine The metabolism of Cyclosporine can be increased when combined with Avasimibe.
Dofetilide The metabolism of Dofetilide can be increased when combined with Avasimibe.
Theophylline The metabolism of Theophylline can be increased when combined with Avasimibe.
Carbamazepine The metabolism of Carbamazepine can be increased when combined with Avasimibe.
Tacrolimus The metabolism of Tacrolimus can be increased when combined with Avasimibe.
Sirolimus The metabolism of Sirolimus can be increased when combined with Avasimibe.

Target Protein

Liver carboxylesterase 1 CES1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 15333513
    Sahi J, Stern RH, Milad MA, Rose KA, Gibson G, Zheng X, Stilgenbauer L, Sadagopan N, Jolley S, Gilbert D, LeCluyse EL: Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo. Drug Metab Dispos. 2004 Dec;32(12):1370-6. Epub 2004 Aug 27.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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