Endostatin

DB06423

biotech investigational

Deskripsi

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

48 Data
Pamidronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Endostatin is combined with Pamidronic acid.
Zoledronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Endostatin is combined with Zoledronic acid.
Alendronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Endostatin is combined with Alendronic acid.
Ibandronate The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Endostatin is combined with Ibandronate.
Clodronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Endostatin is combined with Clodronic acid.
Risedronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Endostatin is combined with Risedronic acid.
Etidronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Endostatin is combined with Etidronic acid.
Tiludronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Endostatin is combined with Tiludronic acid.
Incadronic acid The risk or severity of jaw osteonecrosis and anti-angiogenesis can be increased when Endostatin is combined with Incadronic acid.
Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Endostatin.
Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Endostatin.
Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Endostatin.
Methoxy polyethylene glycol-epoetin beta The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Endostatin.
Lidocaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Quinisocaine.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Endostatin.
Ambroxol The risk or severity of methemoglobinemia can be increased when Endostatin is combined with Ambroxol.
Etrasimod The risk or severity of immunosuppression can be increased when Endostatin is combined with Etrasimod.

Target Protein

72 kDa type IV collagenase MMP2
Matrix metalloproteinase-9 MMP9
Collagenase 3 MMP13
Focal adhesion kinase 1 PTK2
E-selectin SELE

Referensi & Sumber

Artikel (PubMed)
  • PMID: 16376330
    Folkman J: Antiangiogenesis in cancer therapy--endostatin and its mechanisms of action. Exp Cell Res. 2006 Mar 10;312(5):594-607. Epub 2005 Dec 22.
  • PMID: 17644065
    Ling Y, Yang Y, Lu N, You QD, Wang S, Gao Y, Chen Y, Guo QL: Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells. Biochem Biophys Res Commun. 2007 Sep 14;361(1):79-84. Epub 2007 Jul 10.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Endostar

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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