Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 100mg tablets in the treatment of adult HIV-1 infection documented to be resistant to therapy with other NNRTIs and antiretroviral agents. On March 26, 2012, approval was extended for use in treatment-experienced pediatric patients 6 to 18 years of age, weighing at least 16 kg. Etravarine must always be used in combination with other antiretroviral drugs.
Etravirine exerts its effects via direct inhibition of the reverse transcriptase enzyme of human immunodeficiency virus type 1 (HIV-1), and consequently blocks DNA-dependent and RNA-dependent polymerase activity. Etravirine does not inhibit human DNA polymerase alpha, beta or gamma.
Common side effects of use include mild to moderate rash within the first 6 weeks of therapy, nausea, diarrhea and peripheral neuropathy. Patients are advised to immediately contact their healthcare provider if a rash develops.
In 2009, postmarketing case reports of Stevens-Johnson Syndrome, toxic epidermal necrolysis, erythema multiforme, and other hypersensitivity reactions lead to a revision of etravirine's "Warnings and Precautions," as well as notification of health care providers.
In 2013, reports of Autoimmune disorders (such as Graves’ disease, polymyositis, and Guillain-Barré syndrome) in the setting of immune reconstitution, as well as more in depth information about the development of rashes in patients taking etravirine, lead to a modification of etravirine's monograph.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Aripiprazole | The metabolism of Aripiprazole can be increased when combined with Etravirine. |
| Aripiprazole lauroxil | The metabolism of Aripiprazole lauroxil can be increased when combined with Etravirine. |
| Cilostazol | The serum concentration of Cilostazol can be increased when it is combined with Etravirine. |
| Dabrafenib | The serum concentration of Etravirine can be decreased when it is combined with Dabrafenib. |
| Luliconazole | The serum concentration of Etravirine can be increased when it is combined with Luliconazole. |
| Brentuximab vedotin | The metabolism of Brentuximab vedotin can be increased when combined with Etravirine. |
| Phenytoin | The serum concentration of Etravirine can be decreased when it is combined with Phenytoin. |
| Fosphenytoin | The serum concentration of Etravirine can be decreased when it is combined with Fosphenytoin. |
| Linagliptin | The metabolism of Linagliptin can be increased when combined with Etravirine. |
| Daclatasvir | The metabolism of Daclatasvir can be increased when combined with Etravirine. |
| Digoxin | The serum concentration of Digoxin can be increased when it is combined with Etravirine. |
| Metildigoxin | The serum concentration of Metildigoxin can be increased when it is combined with Etravirine. |
| Acetyldigoxin | The serum concentration of Acetyldigoxin can be increased when it is combined with Etravirine. |
| Ritonavir | The serum concentration of Etravirine can be decreased when it is combined with Ritonavir. |
| Rifabutin | The serum concentration of Etravirine can be decreased when it is combined with Rifabutin. |
| Ifosfamide | The metabolism of Ifosfamide can be increased when combined with Etravirine. |
| Perampanel | The metabolism of Perampanel can be increased when combined with Etravirine. |
| Warfarin | The metabolism of Warfarin can be increased when combined with Etravirine. |
| Acenocoumarol | The metabolism of Acenocoumarol can be increased when combined with Etravirine. |
| (R)-warfarin | The metabolism of (R)-warfarin can be increased when combined with Etravirine. |
| R,S-Warfarin alcohol | The metabolism of R,S-Warfarin alcohol can be increased when combined with Etravirine. |
| S,R-Warfarin alcohol | The metabolism of S,R-Warfarin alcohol can be increased when combined with Etravirine. |
| (S)-Warfarin | The metabolism of (S)-Warfarin can be increased when combined with Etravirine. |
| Primidone | The metabolism of Etravirine can be increased when combined with Primidone. |
| Methylphenobarbital | The metabolism of Etravirine can be increased when combined with Methylphenobarbital. |
| Phenobarbital | The metabolism of Etravirine can be increased when combined with Phenobarbital. |
| Diazepam | The metabolism of Diazepam can be decreased when combined with Etravirine. |
| Tipranavir | The serum concentration of Etravirine can be decreased when it is combined with Tipranavir. |
| Atazanavir | The serum concentration of Etravirine can be increased when it is combined with Atazanavir. |
| Amprenavir | The serum concentration of the active metabolites of Amprenavir can be increased when Amprenavir is used in combination with Etravirine. |
| Fosamprenavir | The serum concentration of the active metabolites of Fosamprenavir can be increased when Fosamprenavir is used in combination with Etravirine. |
| Artemether | The serum concentration of the active metabolites of Artemether can be reduced when Artemether is used in combination with Etravirine resulting in a loss in efficacy. |
| Dolutegravir | The serum concentration of Dolutegravir can be decreased when it is combined with Etravirine. |
| Lumacaftor | The serum concentration of Etravirine can be decreased when it is combined with Lumacaftor. |
| Doxorubicin | The serum concentration of Doxorubicin can be decreased when it is combined with Etravirine. |
| Vincristine | The metabolism of Vincristine can be increased when combined with Etravirine. |
| Rolapitant | The metabolism of Rolapitant can be increased when combined with Etravirine. |
| Erlotinib | The serum concentration of Erlotinib can be decreased when it is combined with Etravirine. |
| Diethylstilbestrol | The metabolism of Diethylstilbestrol can be increased when combined with Etravirine. |
| Etonogestrel | The metabolism of Etonogestrel can be increased when combined with Etravirine. |
| Desogestrel | The metabolism of Desogestrel can be increased when combined with Etravirine. |
| Megestrol acetate | The metabolism of Megestrol acetate can be increased when combined with Etravirine. |
| Levonorgestrel | The metabolism of Levonorgestrel can be increased when combined with Etravirine. |
| Progesterone | The metabolism of Progesterone can be increased when combined with Etravirine. |
| Medroxyprogesterone acetate | The metabolism of Medroxyprogesterone acetate can be increased when combined with Etravirine. |
| Norethisterone | The metabolism of Norethisterone can be increased when combined with Etravirine. |
| Estradiol | The metabolism of Estradiol can be increased when combined with Etravirine. |
| Ethynodiol diacetate | The metabolism of Ethynodiol diacetate can be increased when combined with Etravirine. |
| Mifepristone | The metabolism of Mifepristone can be increased when combined with Etravirine. |
| Norgestimate | The metabolism of Norgestimate can be increased when combined with Etravirine. |
| Ethinylestradiol | The metabolism of Ethinylestradiol can be increased when combined with Etravirine. |
| Mestranol | The metabolism of Mestranol can be increased when combined with Etravirine. |
| Drospirenone | The metabolism of Drospirenone can be increased when combined with Etravirine. |
| Estrone sulfate | The metabolism of Estrone sulfate can be increased when combined with Etravirine. |
| Octylphenoxy polyethoxyethanol | The metabolism of Octylphenoxy polyethoxyethanol can be increased when combined with Etravirine. |
| Cyproterone acetate | The metabolism of Cyproterone acetate can be increased when combined with Etravirine. |
| Trestolone | The metabolism of Trestolone can be increased when combined with Etravirine. |
| Norelgestromin | The metabolism of Norelgestromin can be increased when combined with Etravirine. |
| Gestodene | The metabolism of Gestodene can be increased when combined with Etravirine. |
| Hydroxyprogesterone caproate | The metabolism of Hydroxyprogesterone caproate can be increased when combined with Etravirine. |
| Dienogest | The metabolism of Dienogest can be increased when combined with Etravirine. |
| Norethynodrel | The metabolism of Norethynodrel can be increased when combined with Etravirine. |
| Norgestrel | The metabolism of Norgestrel can be increased when combined with Etravirine. |
| Cloprostenol | The metabolism of Cloprostenol can be increased when combined with Etravirine. |
| Gestrinone | The metabolism of Gestrinone can be increased when combined with Etravirine. |
| Nomegestrol | The metabolism of Nomegestrol can be increased when combined with Etravirine. |
| Gossypol | The metabolism of Gossypol can be increased when combined with Etravirine. |
| Ormeloxifene | The metabolism of Ormeloxifene can be increased when combined with Etravirine. |
| Chlormadinone | The metabolism of Chlormadinone can be increased when combined with Etravirine. |
| Norgestrienone | The metabolism of Norgestrienone can be increased when combined with Etravirine. |
| Quingestanol | The metabolism of Quingestanol can be increased when combined with Etravirine. |
| Demegestone | The metabolism of Demegestone can be increased when combined with Etravirine. |
| Etynodiol | The metabolism of Etynodiol can be increased when combined with Etravirine. |
| Testosterone enanthate | The metabolism of Testosterone enanthate can be increased when combined with Etravirine. |
| Estradiol benzoate | The metabolism of Estradiol benzoate can be increased when combined with Etravirine. |
| Estradiol cypionate | The metabolism of Estradiol cypionate can be increased when combined with Etravirine. |
| Estradiol valerate | The metabolism of Estradiol valerate can be increased when combined with Etravirine. |
| Nomegestrol acetate | The metabolism of Nomegestrol acetate can be increased when combined with Etravirine. |
| Norethindrone enanthate | The metabolism of Norethindrone enanthate can be increased when combined with Etravirine. |
| Ulipristal | The metabolism of Ulipristal can be increased when combined with Etravirine. |
| Azithromycin | The metabolism of Azithromycin can be increased when combined with Etravirine. |
| Ziprasidone | The metabolism of Ziprasidone can be increased when combined with Etravirine. |
| Chlorpromazine | The metabolism of Chlorpromazine can be increased when combined with Etravirine. |
| Cephalexin | The metabolism of Cephalexin can be increased when combined with Etravirine. |
| Doxazosin | The metabolism of Doxazosin can be increased when combined with Etravirine. |
| Rosuvastatin | The metabolism of Rosuvastatin can be increased when combined with Etravirine. |
| Allylestrenol | The metabolism of Allylestrenol can be increased when combined with Etravirine. |
| Zuclopenthixol | The metabolism of Zuclopenthixol can be increased when combined with Etravirine. |
| Roflumilast | The metabolism of Roflumilast can be increased when combined with Etravirine. |
| Vorapaxar | The metabolism of Vorapaxar can be increased when combined with Etravirine. |
| Suvorexant | The metabolism of Suvorexant can be increased when combined with Etravirine. |
| Netupitant | The metabolism of Netupitant can be increased when combined with Etravirine. |
| Tasimelteon | The metabolism of Tasimelteon can be increased when combined with Etravirine. |
| Nintedanib | The metabolism of Nintedanib can be increased when combined with Etravirine. |
| Tenofovir alafenamide | The metabolism of Tenofovir alafenamide can be increased when combined with Etravirine. |
| Dihydroergocornine | The metabolism of Dihydroergocornine can be increased when combined with Etravirine. |
| Duvelisib | The metabolism of Duvelisib can be increased when combined with Etravirine. |
| Gilteritinib | The metabolism of Gilteritinib can be increased when combined with Etravirine. |
| 9-aminocamptothecin | The metabolism of 9-aminocamptothecin can be increased when combined with Etravirine. |
| Methylprednisone | The metabolism of Methylprednisone can be increased when combined with Etravirine. |