Indisulam

DB06370

small molecule investigational

Deskripsi

Struktur Molekul 2D

Berat 385.846
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1204 Data
Eliglustat The metabolism of Eliglustat can be decreased when combined with Indisulam.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Indisulam.
Mecamylamine The risk or severity of adverse effects can be increased when Indisulam is combined with Mecamylamine.
Nicotine The risk or severity of adverse effects can be increased when Indisulam is combined with Nicotine.
Pentolinium The risk or severity of adverse effects can be increased when Indisulam is combined with Pentolinium.
Trimethaphan The risk or severity of adverse effects can be increased when Indisulam is combined with Trimethaphan.
Hexamethonium The risk or severity of adverse effects can be increased when Indisulam is combined with Hexamethonium.
Cyclopentamine The risk or severity of adverse effects can be increased when Indisulam is combined with Cyclopentamine.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Indisulam.
Colchicine The metabolism of Colchicine can be decreased when combined with Indisulam.
Fentanyl The therapeutic efficacy of Indisulam can be decreased when used in combination with Fentanyl.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Indisulam.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Indisulam.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Indisulam.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Indisulam.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Indisulam.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Indisulam.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Indisulam.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Indisulam.
Methotrexate The protein binding of Methotrexate can be increased when combined with Indisulam.
Alprazolam The metabolism of Alprazolam can be decreased when combined with Indisulam.
Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Indisulam.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Indisulam.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Indisulam.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Indisulam.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Indisulam.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Indisulam.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Indisulam.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Indisulam.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Indisulam.
Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Indisulam.
Dexketoprofen The risk or severity of adverse effects can be increased when Dexketoprofen is combined with Indisulam.
Ketoprofen The risk or severity of adverse effects can be increased when Ketoprofen is combined with Indisulam.
Cyclosporine The risk or severity of renal failure can be increased when Indisulam is combined with Cyclosporine.
Troglitazone The metabolism of Indisulam can be decreased when combined with Troglitazone.
Nabilone The metabolism of Indisulam can be decreased when combined with Nabilone.
Efavirenz The metabolism of Indisulam can be decreased when combined with Efavirenz.
Mifepristone The metabolism of Indisulam can be decreased when combined with Mifepristone.
Felbamate The metabolism of Indisulam can be decreased when combined with Felbamate.
Sulfinpyrazone The metabolism of Indisulam can be decreased when combined with Sulfinpyrazone.
Iproniazid The metabolism of Indisulam can be decreased when combined with Iproniazid.
Medical Cannabis The metabolism of Indisulam can be decreased when combined with Medical Cannabis.
Imatinib The metabolism of Indisulam can be decreased when combined with Imatinib.
Valproic acid The metabolism of Indisulam can be decreased when combined with Valproic acid.
Fluconazole The metabolism of Indisulam can be decreased when combined with Fluconazole.
Floxuridine The metabolism of Indisulam can be decreased when combined with Floxuridine.
Nicardipine The metabolism of Indisulam can be decreased when combined with Nicardipine.
Delavirdine The metabolism of Indisulam can be decreased when combined with Delavirdine.
Miconazole The metabolism of Indisulam can be decreased when combined with Miconazole.
Gemfibrozil The metabolism of Indisulam can be decreased when combined with Gemfibrozil.
Sulfaphenazole The metabolism of Indisulam can be decreased when combined with Sulfaphenazole.
Sodium phosphate, monobasic Indisulam may increase the nephrotoxic activities of Sodium phosphate, monobasic.
Acemetacin The therapeutic efficacy of Indisulam can be decreased when used in combination with Acemetacin.
Lactulose The risk or severity of dehydration can be increased when Indisulam is combined with Lactulose.
Magnesium sulfate The risk or severity of dehydration can be increased when Indisulam is combined with Magnesium sulfate.
Mannitol The risk or severity of dehydration can be increased when Indisulam is combined with Mannitol.
Lubiprostone The risk or severity of dehydration can be increased when Indisulam is combined with Lubiprostone.
Magnesium oxide The risk or severity of dehydration can be increased when Indisulam is combined with Magnesium oxide.
Magnesium cation The risk or severity of dehydration can be increased when Indisulam is combined with Magnesium cation.
Sorbitol The risk or severity of dehydration can be increased when Indisulam is combined with Sorbitol.
Dantron The risk or severity of dehydration can be increased when Indisulam is combined with Dantron.
Oxyphenisatin The risk or severity of dehydration can be increased when Indisulam is combined with Oxyphenisatin.
Phenolphthalein The risk or severity of dehydration can be increased when Indisulam is combined with Phenolphthalein.
Emodin The risk or severity of dehydration can be increased when Indisulam is combined with Emodin.
Linaclotide The risk or severity of dehydration can be increased when Indisulam is combined with Linaclotide.
Bisacodyl The risk or severity of dehydration can be increased when Indisulam is combined with Bisacodyl.
Magnesium hydroxide The risk or severity of dehydration can be increased when Indisulam is combined with Magnesium hydroxide.
Bisoxatin The risk or severity of dehydration can be increased when Indisulam is combined with Bisoxatin.
Picosulfuric acid The risk or severity of dehydration can be increased when Indisulam is combined with Picosulfuric acid.
Magnesium trisilicate The risk or severity of dehydration can be increased when Indisulam is combined with Magnesium trisilicate.
Polyethylene glycol The risk or severity of dehydration can be increased when Indisulam is combined with Polyethylene glycol.
Polycarbophil The risk or severity of dehydration can be increased when Indisulam is combined with Polycarbophil.
Magnesium acetate tetrahydrate The risk or severity of dehydration can be increased when Indisulam is combined with Magnesium acetate tetrahydrate.
Monopotassium phosphate The risk or severity of dehydration can be increased when Indisulam is combined with Monopotassium phosphate.
Dipotassium phosphate The risk or severity of dehydration can be increased when Indisulam is combined with Dipotassium phosphate.
Glycerin The risk or severity of dehydration can be increased when Indisulam is combined with Glycerin.
Sodium sulfate The risk or severity of dehydration can be increased when Indisulam is combined with Sodium sulfate.
Magnesium carbonate The risk or severity of dehydration can be increased when Indisulam is combined with Magnesium carbonate.
Potassium lactate The risk or severity of dehydration can be increased when Indisulam is combined with Potassium lactate.
Sodium fluorophosphate The risk or severity of dehydration can be increased when Indisulam is combined with Sodium fluorophosphate.
Mineral oil The risk or severity of dehydration can be increased when Indisulam is combined with Mineral oil.
Carboxymethylcellulose The risk or severity of dehydration can be increased when Indisulam is combined with Carboxymethylcellulose.
Docusate The risk or severity of dehydration can be increased when Indisulam is combined with Docusate.
Plantago seed The risk or severity of dehydration can be increased when Indisulam is combined with Plantago seed.
Magnesium citrate The risk or severity of dehydration can be increased when Indisulam is combined with Magnesium citrate.
Castor oil The risk or severity of dehydration can be increased when Indisulam is combined with Castor oil.
Magnesium glycinate The risk or severity of dehydration can be increased when Indisulam is combined with Magnesium glycinate.
Methylcellulose The risk or severity of dehydration can be increased when Indisulam is combined with Methylcellulose.
Sennosides The risk or severity of dehydration can be increased when Indisulam is combined with Sennosides.
Lactitol The risk or severity of dehydration can be increased when Indisulam is combined with Lactitol.
Plecanatide The risk or severity of dehydration can be increased when Indisulam is combined with Plecanatide.
Gluconic Acid The risk or severity of dehydration can be increased when Indisulam is combined with Gluconic Acid.
Magnesium peroxide The risk or severity of dehydration can be increased when Indisulam is combined with Magnesium peroxide.
Pentaerithrityl The risk or severity of dehydration can be increased when Indisulam is combined with Pentaerithrityl.
Sodium tartrate The risk or severity of dehydration can be increased when Indisulam is combined with Sodium tartrate.
Magnesium acetate The risk or severity of dehydration can be increased when Indisulam is combined with Magnesium acetate.
Deacetylbisacodyl The risk or severity of dehydration can be increased when Indisulam is combined with Deacetylbisacodyl.
Sodium ascorbate The risk or severity of dehydration can be increased when Indisulam is combined with Sodium ascorbate.
Potassium sulfate The risk or severity of dehydration can be increased when Indisulam is combined with Potassium sulfate.
Sodium phosphate, dibasic The risk or severity of dehydration can be increased when Indisulam is combined with Sodium phosphate, dibasic.

Target Protein

Carbonic anhydrase 9 CA9

Referensi & Sumber

Artikel (PubMed)
  • PMID: 16565173
    Zandvliet AS, Copalu W, Schellens JH, Beijnen JH, Huitema AD: Saturable binding of indisulam to plasma proteins and distribution to human erythrocytes. Drug Metab Dispos. 2006 Jun;34(6):1041-6. Epub 2006 Mar 24.
  • PMID: 11561678
    Fukuoka K, Usuda J, Iwamoto Y, Fukumoto H, Nakamura T, Yoneda T, Narita N, Saijo N, Nishio K: Mechanisms of action of the novel sulfonamide anticancer agent E7070 on cell cycle progression in human non-small cell lung cancer cells. Invest New Drugs. 2001;19(3):219-27.
  • PMID: 14739663
    van den Bongard HJ, Sparidans RW, Critchley DJ, Beijnen JH, Schellens JH: Pharmacokinetic drug-drug interaction of the novel anticancer agent E7070 and acenocoumarol. Invest New Drugs. 2004 Apr;22(2):151-8.

Contoh Produk & Brand

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