Sitaxentan was marketed under the trade name Thelin for the treatment of pulmonary arterial hypertension (PAH) by Encysive Pharmaceuticals until Pfizer purchased Encysive in February 2008. In 2010, Pfizer voluntarily removed sitaxentan from the market over concerns of hepatotoxicity.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Cyclosporine | The risk or severity of adverse effects can be increased when Cyclosporine is combined with Sitaxentan. |
| Cilostazol | The serum concentration of Cilostazol can be increased when it is combined with Sitaxentan. |
| Amifostine | Sitaxentan may increase the hypotensive activities of Amifostine. |
| Diazoxide | Diazoxide may increase the hypotensive activities of Sitaxentan. |
| Methylphenidate | Methylphenidate may decrease the antihypertensive activities of Sitaxentan. |
| Dexmethylphenidate | Dexmethylphenidate may decrease the antihypertensive activities of Sitaxentan. |
| Obinutuzumab | Sitaxentan may increase the hypotensive activities of Obinutuzumab. |
| Pentoxifylline | Pentoxifylline may increase the hypotensive activities of Sitaxentan. |
| Rituximab | Sitaxentan may increase the hypotensive activities of Rituximab. |
| Desmopressin | Desmopressin may decrease the antihypertensive activities of Sitaxentan. |
| Midodrine | Midodrine may decrease the antihypertensive activities of Sitaxentan. |
| Isoetharine | Isoetharine may decrease the antihypertensive activities of Sitaxentan. |
| Atomoxetine | Atomoxetine may decrease the antihypertensive activities of Sitaxentan. |
| Etomidate | Etomidate may decrease the antihypertensive activities of Sitaxentan. |
| Zolmitriptan | Zolmitriptan may decrease the antihypertensive activities of Sitaxentan. |
| Protriptyline | Protriptyline may decrease the antihypertensive activities of Sitaxentan. |
| Norepinephrine | Norepinephrine may decrease the antihypertensive activities of Sitaxentan. |
| Phenylephrine | Phenylephrine may decrease the antihypertensive activities of Sitaxentan. |
| Phenylpropanolamine | Phenylpropanolamine may decrease the antihypertensive activities of Sitaxentan. |
| Droperidol | Droperidol may decrease the antihypertensive activities of Sitaxentan. |
| Amoxapine | Amoxapine may decrease the antihypertensive activities of Sitaxentan. |
| Doxapram | Doxapram may decrease the antihypertensive activities of Sitaxentan. |
| Atropine | Atropine may decrease the antihypertensive activities of Sitaxentan. |
| Metaraminol | Metaraminol may decrease the antihypertensive activities of Sitaxentan. |
| Sumatriptan | Sumatriptan may decrease the antihypertensive activities of Sitaxentan. |
| Nicergoline | Nicergoline may decrease the antihypertensive activities of Sitaxentan. |
| Methoxamine | Methoxamine may decrease the antihypertensive activities of Sitaxentan. |
| Propiomazine | Propiomazine may decrease the antihypertensive activities of Sitaxentan. |
| Orciprenaline | Orciprenaline may decrease the antihypertensive activities of Sitaxentan. |
| Phenmetrazine | Phenmetrazine may decrease the antihypertensive activities of Sitaxentan. |
| Trifluoperazine | Trifluoperazine may decrease the antihypertensive activities of Sitaxentan. |
| Dobutamine | Dobutamine may decrease the antihypertensive activities of Sitaxentan. |
| Pseudoephedrine | Pseudoephedrine may decrease the antihypertensive activities of Sitaxentan. |
| Ritodrine | Ritodrine may decrease the antihypertensive activities of Sitaxentan. |
| Terbutaline | Terbutaline may decrease the antihypertensive activities of Sitaxentan. |
| Flupentixol | Flupentixol may decrease the antihypertensive activities of Sitaxentan. |
| Bitolterol | Bitolterol may decrease the antihypertensive activities of Sitaxentan. |
| Diethylpropion | Diethylpropion may decrease the antihypertensive activities of Sitaxentan. |
| Naratriptan | Naratriptan may decrease the antihypertensive activities of Sitaxentan. |
| Rizatriptan | Rizatriptan may decrease the antihypertensive activities of Sitaxentan. |
| Dopamine | Dopamine may decrease the antihypertensive activities of Sitaxentan. |
| Frovatriptan | Frovatriptan may decrease the antihypertensive activities of Sitaxentan. |
| Albuterol | Salbutamol may decrease the antihypertensive activities of Sitaxentan. |
| Isoprenaline | Isoprenaline may decrease the antihypertensive activities of Sitaxentan. |
| Arbutamine | Arbutamine may decrease the antihypertensive activities of Sitaxentan. |
| Lisdexamfetamine | Lisdexamfetamine may decrease the antihypertensive activities of Sitaxentan. |
| Fenoterol | Fenoterol may decrease the antihypertensive activities of Sitaxentan. |
| Pirbuterol | Pirbuterol may decrease the antihypertensive activities of Sitaxentan. |
| Ephedra sinica root | Ephedra sinica root may decrease the antihypertensive activities of Sitaxentan. |
| Ephedrine | Ephedrine may decrease the antihypertensive activities of Sitaxentan. |
| Mephentermine | Mephentermine may decrease the antihypertensive activities of Sitaxentan. |
| Procaterol | Procaterol may decrease the antihypertensive activities of Sitaxentan. |
| Methotrimeprazine | Methotrimeprazine may decrease the antihypertensive activities of Sitaxentan. |
| Clenbuterol | Clenbuterol may decrease the antihypertensive activities of Sitaxentan. |
| Bambuterol | Bambuterol may decrease the antihypertensive activities of Sitaxentan. |
| MMDA | MMDA may decrease the antihypertensive activities of Sitaxentan. |
| Midomafetamine | Midomafetamine may decrease the antihypertensive activities of Sitaxentan. |
| 2,5-Dimethoxy-4-ethylamphetamine | 2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Sitaxentan. |
| 4-Methoxyamphetamine | 4-Methoxyamphetamine may decrease the antihypertensive activities of Sitaxentan. |
| 4-Bromo-2,5-dimethoxyamphetamine | 4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Sitaxentan. |
| Tenamfetamine | Tenamfetamine may decrease the antihypertensive activities of Sitaxentan. |
| Chlorphentermine | Chlorphentermine may decrease the antihypertensive activities of Sitaxentan. |
| Dextroamphetamine | Dextroamphetamine may decrease the antihypertensive activities of Sitaxentan. |
| Metamfetamine | Metamfetamine may decrease the antihypertensive activities of Sitaxentan. |
| Phendimetrazine | Phendimetrazine may decrease the antihypertensive activities of Sitaxentan. |
| Periciazine | Periciazine may decrease the antihypertensive activities of Sitaxentan. |
| Acepromazine | Acepromazine may decrease the antihypertensive activities of Sitaxentan. |
| Thioproperazine | Thioproperazine may decrease the antihypertensive activities of Sitaxentan. |
| Epicaptopril | Epicaptopril may decrease the antihypertensive activities of Sitaxentan. |
| 1-benzylimidazole | 1-benzylimidazole may decrease the antihypertensive activities of Sitaxentan. |
| Amineptine | Amineptine may decrease the antihypertensive activities of Sitaxentan. |
| Amibegron | Amibegron may decrease the antihypertensive activities of Sitaxentan. |
| Naluzotan | Naluzotan may decrease the antihypertensive activities of Sitaxentan. |
| Pizotifen | Pizotifen may decrease the antihypertensive activities of Sitaxentan. |
| Solabegron | Solabegron may decrease the antihypertensive activities of Sitaxentan. |
| Droxidopa | Droxidopa may decrease the antihypertensive activities of Sitaxentan. |
| Esmirtazapine | Esmirtazapine may decrease the antihypertensive activities of Sitaxentan. |
| Nitrous oxide | Nitrous oxide may decrease the antihypertensive activities of Sitaxentan. |
| Xylometazoline | Xylometazoline may decrease the antihypertensive activities of Sitaxentan. |
| Isometheptene | Isometheptene may decrease the antihypertensive activities of Sitaxentan. |
| Levonordefrin | Levonordefrin may decrease the antihypertensive activities of Sitaxentan. |
| Naphazoline | Naphazoline may decrease the antihypertensive activities of Sitaxentan. |
| Saralasin | Saralasin may decrease the antihypertensive activities of Sitaxentan. |
| Tetryzoline | Tetryzoline may decrease the antihypertensive activities of Sitaxentan. |
| Cinitapride | Cinitapride may decrease the antihypertensive activities of Sitaxentan. |
| Tyramine | Tyramine may decrease the antihypertensive activities of Sitaxentan. |
| Adrafinil | Adrafinil may decrease the antihypertensive activities of Sitaxentan. |
| Ifenprodil | Ifenprodil may decrease the antihypertensive activities of Sitaxentan. |
| Hexoprenaline | Hexoprenaline may decrease the antihypertensive activities of Sitaxentan. |
| Etilefrine | Etilefrine may decrease the antihypertensive activities of Sitaxentan. |
| Dimetacrine | Dimetacrine may decrease the antihypertensive activities of Sitaxentan. |
| Butriptyline | Butriptyline may decrease the antihypertensive activities of Sitaxentan. |
| Cirazoline | Cirazoline may decrease the antihypertensive activities of Sitaxentan. |
| Synephrine | Synephrine may decrease the antihypertensive activities of Sitaxentan. |
| Moxisylyte | Moxisylyte may decrease the antihypertensive activities of Sitaxentan. |
| Oxaprotiline | Oxaprotiline may decrease the antihypertensive activities of Sitaxentan. |
| Iofetamine I-123 | Iofetamine I-123 may decrease the antihypertensive activities of Sitaxentan. |
| Racepinephrine | Racepinephrine may decrease the antihypertensive activities of Sitaxentan. |
| DL-Methylephedrine | DL-Methylephedrine may decrease the antihypertensive activities of Sitaxentan. |
| Amitraz | Amitraz may decrease the antihypertensive activities of Sitaxentan. |