Udenafil

DB06267

small molecule approved investigational

Deskripsi

Udenafil is a new phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It has been approved in South Korea and will be marketed under the brand name Zydena. It is not yet approved for use in the U.S., E.U., or Canada.

Struktur Molekul 2D

Berat 516.656
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Hepatic. Metabolized by CYP3A4 and CYP3A5.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

697 Data
Alprostadil The risk or severity of hypotension and priapism can be increased when Udenafil is combined with Alprostadil.
Amyl Nitrite The risk or severity of hypotension can be increased when Udenafil is combined with Amyl Nitrite.
Dapoxetine The risk or severity of orthostatic hypotension can be increased when Dapoxetine is combined with Udenafil.
Riociguat Udenafil may increase the hypotensive activities of Riociguat.
Sapropterin Sapropterin may increase the hypotensive activities of Udenafil.
Ethanol Ethanol may increase the hypotensive activities of Udenafil.
Valsartan Udenafil may increase the antihypertensive activities of Valsartan.
Ramipril Udenafil may increase the antihypertensive activities of Ramipril.
Esmolol Udenafil may increase the antihypertensive activities of Esmolol.
Betaxolol Udenafil may increase the antihypertensive activities of Betaxolol.
Remikiren Udenafil may increase the antihypertensive activities of Remikiren.
Torasemide Udenafil may increase the antihypertensive activities of Torasemide.
Bethanidine Udenafil may increase the antihypertensive activities of Bethanidine.
Guanadrel Udenafil may increase the antihypertensive activities of Guanadrel.
Metoprolol Udenafil may increase the antihypertensive activities of Metoprolol.
Olmesartan Udenafil may increase the antihypertensive activities of Olmesartan.
Chlorthalidone Udenafil may increase the antihypertensive activities of Chlorthalidone.
Nitroprusside Udenafil may increase the antihypertensive activities of Nitroprusside.
Atenolol Udenafil may increase the antihypertensive activities of Atenolol.
Minoxidil Udenafil may increase the antihypertensive activities of Minoxidil.
Timolol Udenafil may increase the antihypertensive activities of Timolol.
Treprostinil Udenafil may increase the antihypertensive activities of Treprostinil.
Amlodipine Udenafil may increase the antihypertensive activities of Amlodipine.
Nimodipine Udenafil may increase the antihypertensive activities of Nimodipine.
Bendroflumethiazide Udenafil may increase the antihypertensive activities of Bendroflumethiazide.
Fosinopril Udenafil may increase the antihypertensive activities of Fosinopril.
Trandolapril Udenafil may increase the antihypertensive activities of Trandolapril.
Metolazone Udenafil may increase the antihypertensive activities of Metolazone.
Lercanidipine Udenafil may increase the antihypertensive activities of Lercanidipine.
Benazepril Udenafil may increase the antihypertensive activities of Benazepril.
Bosentan Udenafil may increase the antihypertensive activities of Bosentan.
Propranolol Udenafil may increase the antihypertensive activities of Propranolol.
Enalapril Udenafil may increase the antihypertensive activities of Enalapril.
Cyclothiazide Udenafil may increase the antihypertensive activities of Cyclothiazide.
Bisoprolol Udenafil may increase the antihypertensive activities of Bisoprolol.
Candoxatril Udenafil may increase the antihypertensive activities of Candoxatril.
Guanabenz Udenafil may increase the antihypertensive activities of Guanabenz.
Mecamylamine The risk or severity of adverse effects can be increased when Udenafil is combined with Mecamylamine.
Losartan Udenafil may increase the antihypertensive activities of Losartan.
Moexipril Udenafil may increase the antihypertensive activities of Moexipril.
Lisinopril Udenafil may increase the antihypertensive activities of Lisinopril.
Metyrosine Udenafil may increase the antihypertensive activities of Metyrosine.
Hydroflumethiazide Udenafil may increase the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Udenafil may increase the antihypertensive activities of Cryptenamine.
Perindopril Udenafil may increase the antihypertensive activities of Perindopril.
Candesartan cilexetil Udenafil may increase the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Udenafil may increase the antihypertensive activities of Fenoldopam.
Indapamide Udenafil may increase the antihypertensive activities of Indapamide.
Alprenolol Udenafil may increase the antihypertensive activities of Alprenolol.
Eprosartan Udenafil may increase the antihypertensive activities of Eprosartan.
Chlorothiazide Udenafil may increase the antihypertensive activities of Chlorothiazide.
Quinapril Udenafil may increase the antihypertensive activities of Quinapril.
Omapatrilat Udenafil may increase the antihypertensive activities of Omapatrilat.
Pindolol Udenafil may increase the antihypertensive activities of Pindolol.
Telmisartan Udenafil may increase the antihypertensive activities of Telmisartan.
Methyldopa Udenafil may increase the antihypertensive activities of Methyldopa.
Hydrochlorothiazide Udenafil may increase the antihypertensive activities of Hydrochlorothiazide.
Guanfacine Udenafil may increase the antihypertensive activities of Guanfacine.
Trichlormethiazide Udenafil may increase the antihypertensive activities of Trichlormethiazide.
Irbesartan Udenafil may increase the antihypertensive activities of Irbesartan.
Nitrendipine Udenafil may increase the antihypertensive activities of Nitrendipine.
Deserpidine Udenafil may increase the antihypertensive activities of Deserpidine.
Pentolinium The risk or severity of adverse effects can be increased when Udenafil is combined with Pentolinium.
Trimethaphan The risk or severity of adverse effects can be increased when Udenafil is combined with Trimethaphan.
Diazoxide Udenafil may increase the antihypertensive activities of Diazoxide.
Bretylium Udenafil may increase the antihypertensive activities of Bretylium.
Guanethidine Udenafil may increase the antihypertensive activities of Guanethidine.
Rescinnamine Udenafil may increase the antihypertensive activities of Rescinnamine.
Acebutolol Udenafil may increase the antihypertensive activities of Acebutolol.
Captopril Udenafil may increase the antihypertensive activities of Captopril.
Nadolol Udenafil may increase the antihypertensive activities of Nadolol.
Epoprostenol Udenafil may increase the antihypertensive activities of Epoprostenol.
Bepridil Udenafil may increase the antihypertensive activities of Bepridil.
Hydralazine Udenafil may increase the antihypertensive activities of Hydralazine.
Practolol Udenafil may increase the antihypertensive activities of Practolol.
Polythiazide Udenafil may increase the antihypertensive activities of Polythiazide.
Cilazapril Udenafil may increase the antihypertensive activities of Cilazapril.
Saprisartan Udenafil may increase the antihypertensive activities of Saprisartan.
Spirapril Udenafil may increase the antihypertensive activities of Spirapril.
Penbutolol Udenafil may increase the antihypertensive activities of Penbutolol.
Oxprenolol Udenafil may increase the antihypertensive activities of Oxprenolol.
Pargyline Udenafil may increase the antihypertensive activities of Pargyline.
Dexpropranolol Udenafil may increase the antihypertensive activities of Dexpropranolol.
Tienilic acid Udenafil may increase the antihypertensive activities of Tienilic acid.
Debrisoquine Udenafil may increase the antihypertensive activities of Debrisoquine.
Celiprolol Udenafil may increase the antihypertensive activities of Celiprolol.
Nebivolol Udenafil may increase the antihypertensive activities of Nebivolol.
Lofexidine Udenafil may increase the antihypertensive activities of Lofexidine.
Sitaxentan Udenafil may increase the antihypertensive activities of Sitaxentan.
Ambrisentan Udenafil may increase the antihypertensive activities of Ambrisentan.
Diethylnorspermine Udenafil may increase the antihypertensive activities of Diethylnorspermine.
Pinacidil Udenafil may increase the antihypertensive activities of Pinacidil.
Bupranolol Udenafil may increase the antihypertensive activities of Bupranolol.
Temocapril Udenafil may increase the antihypertensive activities of Temocapril.
Macitentan Udenafil may increase the antihypertensive activities of Macitentan.
Indenolol Udenafil may increase the antihypertensive activities of Indenolol.
Hexamethonium The risk or severity of adverse effects can be increased when Udenafil is combined with Hexamethonium.
Aliskiren Udenafil may increase the antihypertensive activities of Aliskiren.
Efonidipine Udenafil may increase the antihypertensive activities of Efonidipine.
Lacidipine Udenafil may increase the antihypertensive activities of Lacidipine.

Target Protein

cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A

Referensi & Sumber

Synthesis reference: Chan-Ho Lee, Chang-Yong Shin, Seul-Min Choi, Kyung-Koo Kang, Dong-Seong Kim, Byoung-Ok Ahn, Moo-Hi Yoo, "ACID ADDITION SALT OF UDENAFIL, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME." U.S. Patent US20110306762, issued December 15, 2011.
Artikel (PubMed)
  • PMID: 17958337
    Ji HY, Shim HJ, Yoo M, Park ES, Lee HS: Transport of a new erectogenic udenafil in Caco-2 cells. Arch Pharm Res. 2007 Sep;30(9):1168-73.
  • PMID: 18308836
    Ku HY, Ahn HJ, Seo KA, Kim H, Oh M, Bae SK, Shin JG, Shon JH, Liu KH: The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil. Drug Metab Dispos. 2008 Jun;36(6):986-90. doi: 10.1124/dmd.107.020099. Epub 2008 Feb 28.

Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Zydena

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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