Vadimezan

DB06235

small molecule investigational

Deskripsi

Struktur Molekul 2D

Berat 282.2907
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

354 Data
Deferasirox The serum concentration of Vadimezan can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Vadimezan can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Vadimezan can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Vadimezan can be decreased when it is combined with Teriflunomide.
Abiraterone The serum concentration of Vadimezan can be increased when it is combined with Abiraterone.
Cyproterone acetate The metabolism of Vadimezan can be increased when combined with Cyproterone acetate.
Carbamazepine The metabolism of Vadimezan can be increased when combined with Carbamazepine.
Primidone The metabolism of Vadimezan can be increased when combined with Primidone.
Rifampin The metabolism of Vadimezan can be increased when combined with Rifampicin.
Albendazole The metabolism of Vadimezan can be increased when combined with Albendazole.
Caffeine The metabolism of Vadimezan can be decreased when combined with Caffeine.
Moxifloxacin The metabolism of Vadimezan can be decreased when combined with Moxifloxacin.
Lidocaine The risk or severity of methemoglobinemia can be increased when Vadimezan is combined with Lidocaine.
Mexiletine The metabolism of Vadimezan can be decreased when combined with Mexiletine.
Imipramine The metabolism of Vadimezan can be decreased when combined with Imipramine.
Alosetron The metabolism of Vadimezan can be decreased when combined with Alosetron.
Ketoconazole The metabolism of Vadimezan can be decreased when combined with Ketoconazole.
Gatifloxacin The metabolism of Vadimezan can be decreased when combined with Gatifloxacin.
Simeprevir The metabolism of Vadimezan can be decreased when combined with Simeprevir.
Lobeglitazone The metabolism of Vadimezan can be decreased when combined with Lobeglitazone.
Pazufloxacin The metabolism of Vadimezan can be decreased when combined with Pazufloxacin.
Osilodrostat The metabolism of Vadimezan can be decreased when combined with Osilodrostat.
Osimertinib The serum concentration of Vadimezan can be decreased when it is combined with Osimertinib.
Vemurafenib The serum concentration of Vadimezan can be increased when it is combined with Vemurafenib.
Citalopram The metabolism of Vadimezan can be decreased when combined with Citalopram.
Cimetidine The metabolism of Vadimezan can be decreased when combined with Cimetidine.
Trovafloxacin The metabolism of Vadimezan can be decreased when combined with Trovafloxacin.
Viloxazine The metabolism of Vadimezan can be decreased when combined with Viloxazine.
Pipemidic acid The metabolism of Vadimezan can be decreased when combined with Pipemidic acid.
Nevirapine The metabolism of Vadimezan can be decreased when combined with Nevirapine.
Famotidine The metabolism of Vadimezan can be decreased when combined with Famotidine.
Ethambutol The metabolism of Vadimezan can be decreased when combined with Ethambutol.
Belinostat The metabolism of Vadimezan can be increased when combined with Belinostat.
Insulin pork The metabolism of Vadimezan can be increased when combined with Insulin pork.
Phenylephrine The metabolism of Vadimezan can be increased when combined with Phenylephrine.
Nafcillin The metabolism of Vadimezan can be increased when combined with Nafcillin.
Fosphenytoin The metabolism of Vadimezan can be increased when combined with Fosphenytoin.
NN344 The metabolism of Vadimezan can be increased when combined with NN344.
Armodafinil The metabolism of Vadimezan can be increased when combined with Armodafinil.
beta-Naphthoflavone The metabolism of Vadimezan can be increased when combined with beta-Naphthoflavone.
Insulin peglispro The metabolism of Vadimezan can be increased when combined with Insulin peglispro.
Insulin tregopil The metabolism of Vadimezan can be increased when combined with Insulin tregopil.
Pitolisant The metabolism of Vadimezan can be increased when combined with Pitolisant.
Insulin beef The metabolism of Vadimezan can be increased when combined with Insulin beef.
Ritonavir The metabolism of Vadimezan can be increased when combined with Ritonavir.
Somatotropin The metabolism of Vadimezan can be increased when combined with Somatotropin.
Somapacitan The metabolism of Vadimezan can be increased when combined with Somapacitan.
Peginterferon alfa-2a The metabolism of Vadimezan can be decreased when combined with Peginterferon alfa-2a.
Interferon alfa-n1 The metabolism of Vadimezan can be decreased when combined with Interferon alfa-n1.
Interferon alfa-n3 The metabolism of Vadimezan can be decreased when combined with Interferon alfa-n3.
Interferon gamma-1b The metabolism of Vadimezan can be decreased when combined with Interferon gamma-1b.
Interferon alfa-2a The metabolism of Vadimezan can be decreased when combined with Interferon alfa-2a.
Interferon beta-1a The metabolism of Vadimezan can be decreased when combined with Interferon beta-1a.
Interferon beta-1b The metabolism of Vadimezan can be decreased when combined with Interferon beta-1b.
Interferon alfacon-1 The metabolism of Vadimezan can be decreased when combined with Interferon alfacon-1.
Interferon alfa-2b The metabolism of Vadimezan can be decreased when combined with Interferon alfa-2b.
Ticlopidine The metabolism of Vadimezan can be decreased when combined with Ticlopidine.
Valproic acid The metabolism of Vadimezan can be decreased when combined with Valproic acid.
Promazine The metabolism of Vadimezan can be decreased when combined with Promazine.
Pefloxacin The metabolism of Vadimezan can be decreased when combined with Pefloxacin.
Methoxsalen The metabolism of Vadimezan can be decreased when combined with Methoxsalen.
Efavirenz The metabolism of Vadimezan can be decreased when combined with Efavirenz.
Dexmedetomidine The metabolism of Vadimezan can be decreased when combined with Dexmedetomidine.
Thiabendazole The metabolism of Vadimezan can be decreased when combined with Thiabendazole.
Methimazole The metabolism of Vadimezan can be decreased when combined with Methimazole.
Nalidixic acid The metabolism of Vadimezan can be decreased when combined with Nalidixic acid.
Rosoxacin The metabolism of Vadimezan can be decreased when combined with Rosoxacin.
Cinoxacin The metabolism of Vadimezan can be decreased when combined with Cinoxacin.
Isoniazid The metabolism of Vadimezan can be decreased when combined with Isoniazid.
Norfloxacin The metabolism of Vadimezan can be decreased when combined with Norfloxacin.
Tegaserod The metabolism of Vadimezan can be decreased when combined with Tegaserod.
Gemifloxacin The metabolism of Vadimezan can be decreased when combined with Gemifloxacin.
Orphenadrine The metabolism of Vadimezan can be decreased when combined with Orphenadrine.
Propafenone The metabolism of Vadimezan can be decreased when combined with Propafenone.
Gemfibrozil The metabolism of Vadimezan can be decreased when combined with Gemfibrozil.
Mibefradil The metabolism of Vadimezan can be decreased when combined with Mibefradil.
Estrone sulfate The metabolism of Vadimezan can be decreased when combined with Estrone sulfate.
Albinterferon Alfa-2B The metabolism of Vadimezan can be decreased when combined with Albinterferon Alfa-2B.
Obeticholic acid The metabolism of Vadimezan can be decreased when combined with Obeticholic acid.
Garenoxacin The metabolism of Vadimezan can be decreased when combined with Garenoxacin.
Nemonoxacin The metabolism of Vadimezan can be decreased when combined with Nemonoxacin.
Niclosamide The metabolism of Vadimezan can be decreased when combined with Niclosamide.
Flumequine The metabolism of Vadimezan can be decreased when combined with Flumequine.
Stiripentol The metabolism of Vadimezan can be increased when combined with Stiripentol.
Enrofloxacin The metabolism of Vadimezan can be decreased when combined with Enrofloxacin.
Orbifloxacin The metabolism of Vadimezan can be decreased when combined with Orbifloxacin.
Sarafloxacin The metabolism of Vadimezan can be decreased when combined with Sarafloxacin.
Difloxacin The metabolism of Vadimezan can be decreased when combined with Difloxacin.
Diacerein The metabolism of Vadimezan can be decreased when combined with Diacerein.
Triclabendazole The metabolism of Vadimezan can be decreased when combined with Triclabendazole.
Dihydralazine The metabolism of Vadimezan can be decreased when combined with Dihydralazine.
Rhein The metabolism of Vadimezan can be decreased when combined with Rhein.
Sitafloxacin The metabolism of Vadimezan can be decreased when combined with Sitafloxacin.
Enasidenib The metabolism of Vadimezan can be decreased when combined with Enasidenib.
Estradiol acetate The metabolism of Vadimezan can be decreased when combined with Estradiol acetate.
Ropeginterferon alfa-2b The metabolism of Vadimezan can be decreased when combined with Ropeginterferon alfa-2b.
Interferon alfa-2c The metabolism of Vadimezan can be decreased when combined with Interferon alfa-2c.
Avasimibe The metabolism of Vadimezan can be decreased when combined with Avasimibe.
Cepeginterferon alfa-2B The metabolism of Vadimezan can be decreased when combined with Cepeginterferon alfa-2B.
Medical Cannabis The metabolism of Vadimezan can be decreased when combined with Medical Cannabis.

Target Protein

Transcription factor RelB RELB
Nuclear factor NF-kappa-B p105 subunit NFKB1
Nuclear factor NF-kappa-B p100 subunit NFKB2
Transcription factor p65 RELA
Proto-oncogene c-Rel REL

Referensi & Sumber

Artikel (PubMed)
  • PMID: 15800918
    Zhao L, Ching LM, Kestell P, Kelland LR, Baguley BC: Mechanisms of tumor vascular shutdown induced by 5,6-dimethylxanthenone-4-acetic acid (DMXAA): Increased tumor vascular permeability. Int J Cancer. 2005 Aug 20;116(2):322-6.
  • PMID: 18095916
    McKeage MJ: The potential of DMXAA (ASA404) in combination with docetaxel in advanced prostate cancer. Expert Opin Investig Drugs. 2008 Jan;17(1):23-9.
Link

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Sekuens Gen/Protein (FASTA)

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