Peringatan Keamanan

The most common (incidence ? 5%) adverse reactions to regadenoson are dyspnea, headache, flushing, chest discomfort, dizziness, angina pectoris, chest pain, and nausea.
MTD (male, supine position): 20 µg/kg;
MTD (male, standing position): 10 µg/kg;

Regadenoson

DB06213

small molecule approved investigational

Deskripsi

Regadenoson is an A2A adenosine receptor agonist that causes coronary vasodilation and used for myocardial perfusion imagining. Manufactured by Astellas and FDA approved April 10, 2008.

Struktur Molekul 2D

Berat 390.354
Wujud liquid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Initial phase: 2-4 minutes; Intermediate phase: 30 minutes (this phase coincides with a loss of the pharmacodynamic effect); Terminal phase: 2 hours
Volume Distribusi Central compartment: 11.5 L; Steady state: 78.7 L
Klirens (Clearance) Average plasma renal clearance = 450 mL/min. As this value is larger than the glomerular filtration rate, this suggests occurrence of renal tubular secretion.

Absorpsi

The pharmacokinetic profile of regadenoson is best described by a 3-compartment model. T max, injection = 1 to 3 minutes; Onset of pharmacodynamic response = 1 to 3 minutes; E max 12.3 ng/mL

Metabolisme

The metabolism of regadenoson is unknown in humans. The cytochrome P450 enzyme system is not likely to be involved with the metabolism of regadenoson.

Rute Eliminasi

58% of total regadenoson eliminate is via renal excretion

Interaksi Makanan

1 Data
  • 1. Avoid caffeine. Do not consume caffeine for at least 12 hours before the administration of regadenoson as caffeine can reduce the ability to detect ischemic changes.

Interaksi Obat

40 Data
Caffeine Caffeine may decrease effectiveness of Regadenoson as a diagnostic agent.
Theophylline Theophylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Dyphylline Dyphylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Pentoxifylline Pentoxifylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Mercaptopurine Mercaptopurine may decrease effectiveness of Regadenoson as a diagnostic agent.
Aminophylline Aminophylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Oxtriphylline Oxtriphylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Theobromine Theobromine may decrease effectiveness of Regadenoson as a diagnostic agent.
Fenethylline Fenethylline may decrease effectiveness of Regadenoson as a diagnostic agent.
8-azaguanine 8-azaguanine may decrease effectiveness of Regadenoson as a diagnostic agent.
7,9-Dimethylguanine 7,9-Dimethylguanine may decrease effectiveness of Regadenoson as a diagnostic agent.
Xanthine Xanthine may decrease effectiveness of Regadenoson as a diagnostic agent.
7-Deazaguanine 7-Deazaguanine may decrease effectiveness of Regadenoson as a diagnostic agent.
Guanine Guanine may decrease effectiveness of Regadenoson as a diagnostic agent.
9-Methylguanine 9-Methylguanine may decrease effectiveness of Regadenoson as a diagnostic agent.
Peldesine Peldesine may decrease effectiveness of Regadenoson as a diagnostic agent.
Hypoxanthine Hypoxanthine may decrease effectiveness of Regadenoson as a diagnostic agent.
9-Deazaguanine 9-Deazaguanine may decrease effectiveness of Regadenoson as a diagnostic agent.
Propentofylline Propentofylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Valomaciclovir Valomaciclovir may decrease effectiveness of Regadenoson as a diagnostic agent.
3-isobutyl-1-methyl-7H-xanthine 3-isobutyl-1-methyl-7H-xanthine may decrease effectiveness of Regadenoson as a diagnostic agent.
Uric acid Uric acid may decrease effectiveness of Regadenoson as a diagnostic agent.
Doxofylline Doxofylline may decrease effectiveness of Regadenoson as a diagnostic agent.
6-O-benzylguanine 6-O-benzylguanine may decrease effectiveness of Regadenoson as a diagnostic agent.
Lisofylline Lisofylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Lobucavir Lobucavir may decrease effectiveness of Regadenoson as a diagnostic agent.
Cafedrine Cafedrine may decrease effectiveness of Regadenoson as a diagnostic agent.
Theodrenaline Theodrenaline may decrease effectiveness of Regadenoson as a diagnostic agent.
Bamifylline Bamifylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Proxyphylline Proxyphylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Acefylline Acefylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Etamiphylline Etamiphylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Pentifylline Pentifylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Bufylline Bufylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Bromotheophylline Bromotheophylline may decrease effectiveness of Regadenoson as a diagnostic agent.
Furafylline Furafylline may decrease effectiveness of Regadenoson as a diagnostic agent.
8-chlorotheophylline 8-chlorotheophylline may decrease effectiveness of Regadenoson as a diagnostic agent.
PCS-499 PCS-499 may decrease effectiveness of Regadenoson as a diagnostic agent.
Dipyridamole The risk or severity of adverse effects can be increased when Dipyridamole is combined with Regadenoson.
Lomifylline Lomifylline may decrease effectiveness of Regadenoson as a diagnostic agent.

Target Protein

Adenosine receptor A2a ADORA2A

Referensi & Sumber

Artikel (PubMed)
  • PMID: 18477777
    Mitka M: New stress test agents reduce adverse effects. JAMA. 2008 May 14;299(18):2140. doi: 10.1001/jama.299.18.2140.
  • PMID: 17679059
    Lieu HD, Shryock JC, von Mering GO, Gordi T, Blackburn B, Olmsted AW, Belardinelli L, Kerensky RA: Regadenoson, a selective A2A adenosine receptor agonist, causes dose-dependent increases in coronary blood flow velocity in humans. J Nucl Cardiol. 2007 Jul;14(4):514-20.
  • PMID: 22130964
    Zoghbi GJ, Iskandrian AE: Selective adenosine agonists and myocardial perfusion imaging. J Nucl Cardiol. 2012 Feb;19(1):126-41. doi: 10.1007/s12350-011-9474-9.

Contoh Produk & Brand

Produk: 15 • International brands: 0
Produk
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    Injection • 0.08 mg/1mL • Intravenous • US • Generic • Approved
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    Injection, solution • 0.08 mg/1mL • Intravenous • US • Generic • Approved
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