Patients with severe renal impairment (with creatinine clearance below 30 mL/min) should avoid use of drug as their clearance of the drug is reduced and there is inconsistent evidence about its safety in this subset of patients.
Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Lepirudin | The risk or severity of bleeding and hemorrhage can be increased when Lepirudin is combined with Sugammadex. |
| Bivalirudin | The risk or severity of bleeding and hemorrhage can be increased when Bivalirudin is combined with Sugammadex. |
| Alteplase | The risk or severity of bleeding and hemorrhage can be increased when Alteplase is combined with Sugammadex. |
| Urokinase | The risk or severity of bleeding and hemorrhage can be increased when Urokinase is combined with Sugammadex. |
| Reteplase | The risk or severity of bleeding and hemorrhage can be increased when Reteplase is combined with Sugammadex. |
| Anistreplase | The risk or severity of bleeding and hemorrhage can be increased when Anistreplase is combined with Sugammadex. |
| Tenecteplase | The risk or severity of bleeding and hemorrhage can be increased when Tenecteplase is combined with Sugammadex. |
| Abciximab | The risk or severity of bleeding and hemorrhage can be increased when Abciximab is combined with Sugammadex. |
| Drotrecogin alfa | The risk or severity of bleeding and hemorrhage can be increased when Drotrecogin alfa is combined with Sugammadex. |
| Streptokinase | The risk or severity of bleeding and hemorrhage can be increased when Streptokinase is combined with Sugammadex. |
| Dicoumarol | The risk or severity of bleeding and hemorrhage can be increased when Dicoumarol is combined with Sugammadex. |
| Argatroban | The risk or severity of bleeding and hemorrhage can be increased when Argatroban is combined with Sugammadex. |
| Ardeparin | The risk or severity of bleeding and hemorrhage can be increased when Ardeparin is combined with Sugammadex. |
| Phenindione | The risk or severity of bleeding and hemorrhage can be increased when Phenindione is combined with Sugammadex. |
| Fondaparinux | The risk or severity of bleeding and hemorrhage can be increased when Fondaparinux is combined with Sugammadex. |
| Warfarin | The risk or severity of bleeding and hemorrhage can be increased when Warfarin is combined with Sugammadex. |
| Pentosan polysulfate | The risk or severity of bleeding and hemorrhage can be increased when Pentosan polysulfate is combined with Sugammadex. |
| Phenprocoumon | The risk or severity of bleeding and hemorrhage can be increased when Phenprocoumon is combined with Sugammadex. |
| Dipyridamole | The risk or severity of bleeding and hemorrhage can be increased when Dipyridamole is combined with Sugammadex. |
| Heparin | The risk or severity of bleeding and hemorrhage can be increased when Heparin is combined with Sugammadex. |
| Enoxaparin | The risk or severity of bleeding and hemorrhage can be increased when Enoxaparin is combined with Sugammadex. |
| Epoprostenol | The risk or severity of bleeding and hemorrhage can be increased when Epoprostenol is combined with Sugammadex. |
| Acenocoumarol | The risk or severity of bleeding and hemorrhage can be increased when Acenocoumarol is combined with Sugammadex. |
| 4-hydroxycoumarin | The risk or severity of bleeding and hemorrhage can be increased when 4-hydroxycoumarin is combined with Sugammadex. |
| Coumarin | The risk or severity of bleeding and hemorrhage can be increased when Coumarin is combined with Sugammadex. |
| Ximelagatran | The risk or severity of bleeding and hemorrhage can be increased when Ximelagatran is combined with Sugammadex. |
| Desmoteplase | The risk or severity of bleeding and hemorrhage can be increased when Desmoteplase is combined with Sugammadex. |
| Defibrotide | The risk or severity of bleeding and hemorrhage can be increased when Defibrotide is combined with Sugammadex. |
| Ancrod | The risk or severity of bleeding and hemorrhage can be increased when Ancrod is combined with Sugammadex. |
| Beraprost | The risk or severity of bleeding and hemorrhage can be increased when Beraprost is combined with Sugammadex. |
| Prasugrel | The risk or severity of bleeding and hemorrhage can be increased when Prasugrel is combined with Sugammadex. |
| Rivaroxaban | The risk or severity of bleeding and hemorrhage can be increased when Rivaroxaban is combined with Sugammadex. |
| Sulodexide | The risk or severity of bleeding and hemorrhage can be increased when Sulodexide is combined with Sugammadex. |
| Semuloparin | The risk or severity of bleeding and hemorrhage can be increased when Semuloparin is combined with Sugammadex. |
| Idraparinux | The risk or severity of bleeding and hemorrhage can be increased when Idraparinux is combined with Sugammadex. |
| Cangrelor | The risk or severity of bleeding and hemorrhage can be increased when Cangrelor is combined with Sugammadex. |
| Astaxanthin | The risk or severity of bleeding and hemorrhage can be increased when Astaxanthin is combined with Sugammadex. |
| Apixaban | The risk or severity of bleeding and hemorrhage can be increased when Apixaban is combined with Sugammadex. |
| Otamixaban | The risk or severity of bleeding and hemorrhage can be increased when Otamixaban is combined with Sugammadex. |
| Amediplase | The risk or severity of bleeding and hemorrhage can be increased when Amediplase is combined with Sugammadex. |
| Dabigatran etexilate | The risk or severity of bleeding and hemorrhage can be increased when Dabigatran etexilate is combined with Sugammadex. |
| Danaparoid | The risk or severity of bleeding and hemorrhage can be increased when Danaparoid is combined with Sugammadex. |
| Dalteparin | The risk or severity of bleeding and hemorrhage can be increased when Dalteparin is combined with Sugammadex. |
| Tinzaparin | The risk or severity of bleeding and hemorrhage can be increased when Tinzaparin is combined with Sugammadex. |
| (R)-warfarin | The risk or severity of bleeding and hemorrhage can be increased when (R)-warfarin is combined with Sugammadex. |
| Ethyl biscoumacetate | The risk or severity of bleeding and hemorrhage can be increased when Ethyl biscoumacetate is combined with Sugammadex. |
| Nadroparin | The risk or severity of bleeding and hemorrhage can be increased when Nadroparin is combined with Sugammadex. |
| Triflusal | The risk or severity of bleeding and hemorrhage can be increased when Triflusal is combined with Sugammadex. |
| Ticagrelor | The risk or severity of bleeding and hemorrhage can be increased when Ticagrelor is combined with Sugammadex. |
| Ditazole | The risk or severity of bleeding and hemorrhage can be increased when Ditazole is combined with Sugammadex. |
| Vorapaxar | The risk or severity of bleeding and hemorrhage can be increased when Vorapaxar is combined with Sugammadex. |
| Edoxaban | The risk or severity of bleeding and hemorrhage can be increased when Edoxaban is combined with Sugammadex. |
| Sodium citrate | The risk or severity of bleeding and hemorrhage can be increased when Sodium citrate is combined with Sugammadex. |
| Dextran | The risk or severity of bleeding and hemorrhage can be increased when Dextran is combined with Sugammadex. |
| Bemiparin | The risk or severity of bleeding and hemorrhage can be increased when Bemiparin is combined with Sugammadex. |
| Parnaparin | The risk or severity of bleeding and hemorrhage can be increased when Parnaparin is combined with Sugammadex. |
| Desirudin | The risk or severity of bleeding and hemorrhage can be increased when Desirudin is combined with Sugammadex. |
| Antithrombin Alfa | The risk or severity of bleeding and hemorrhage can be increased when Antithrombin Alfa is combined with Sugammadex. |
| Protein C | The risk or severity of bleeding and hemorrhage can be increased when Protein C is combined with Sugammadex. |
| Antithrombin III human | The risk or severity of bleeding and hemorrhage can be increased when Antithrombin III human is combined with Sugammadex. |
| Letaxaban | The risk or severity of bleeding and hemorrhage can be increased when Letaxaban is combined with Sugammadex. |
| Darexaban | The risk or severity of bleeding and hemorrhage can be increased when Darexaban is combined with Sugammadex. |
| Betrixaban | The risk or severity of bleeding and hemorrhage can be increased when Betrixaban is combined with Sugammadex. |
| Nafamostat | The risk or severity of bleeding and hemorrhage can be increased when Nafamostat is combined with Sugammadex. |
| Monteplase | The risk or severity of bleeding and hemorrhage can be increased when Monteplase is combined with Sugammadex. |
| Gabexate | The risk or severity of bleeding and hemorrhage can be increased when Gabexate is combined with Sugammadex. |
| Fluindione | The risk or severity of bleeding and hemorrhage can be increased when Fluindione is combined with Sugammadex. |
| Protein S human | The risk or severity of bleeding and hemorrhage can be increased when Protein S human is combined with Sugammadex. |
| Brinase | The risk or severity of bleeding and hemorrhage can be increased when Brinase is combined with Sugammadex. |
| Clorindione | The risk or severity of bleeding and hemorrhage can be increased when Clorindione is combined with Sugammadex. |
| Diphenadione | The risk or severity of bleeding and hemorrhage can be increased when Diphenadione is combined with Sugammadex. |
| Tioclomarol | The risk or severity of bleeding and hemorrhage can be increased when Tioclomarol is combined with Sugammadex. |
| Melagatran | The risk or severity of bleeding and hemorrhage can be increased when Melagatran is combined with Sugammadex. |
| Saruplase | The risk or severity of bleeding and hemorrhage can be increased when Saruplase is combined with Sugammadex. |
| (S)-Warfarin | The risk or severity of bleeding and hemorrhage can be increased when (S)-Warfarin is combined with Sugammadex. |
| Tocopherylquinone | The risk or severity of bleeding and hemorrhage can be increased when Tocopherylquinone is combined with Sugammadex. |
| Dabigatran | The risk or severity of bleeding and hemorrhage can be increased when Dabigatran is combined with Sugammadex. |
| Troxerutin | The risk or severity of bleeding and hemorrhage can be increased when Troxerutin is combined with Sugammadex. |
| Edetic acid | The risk or severity of bleeding and hemorrhage can be increased when Edetic acid is combined with Sugammadex. |
| Reviparin | The risk or severity of bleeding and hemorrhage can be increased when Reviparin is combined with Sugammadex. |
| Dermatan sulfate | The risk or severity of bleeding and hemorrhage can be increased when Dermatan sulfate is combined with Sugammadex. |
| SR-123781A | The risk or severity of bleeding and hemorrhage can be increased when SR-123781A is combined with Sugammadex. |
| Desogestrel | The serum concentration of Desogestrel can be decreased when it is combined with Sugammadex. |
| Megestrol acetate | The serum concentration of Megestrol acetate can be decreased when it is combined with Sugammadex. |
| Levonorgestrel | The serum concentration of Levonorgestrel can be decreased when it is combined with Sugammadex. |
| Medroxyprogesterone acetate | The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Sugammadex. |
| Norethisterone | The serum concentration of Norethisterone can be decreased when it is combined with Sugammadex. |
| Ethynodiol diacetate | The serum concentration of Ethynodiol diacetate can be decreased when it is combined with Sugammadex. |
| Norgestimate | The serum concentration of Norgestimate can be decreased when it is combined with Sugammadex. |
| Drospirenone | The serum concentration of Drospirenone can be decreased when it is combined with Sugammadex. |
| Cyproterone acetate | The serum concentration of Cyproterone acetate can be decreased when it is combined with Sugammadex. |
| Gestodene | The serum concentration of Gestodene can be decreased when it is combined with Sugammadex. |
| Hydroxyprogesterone caproate | The serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Sugammadex. |
| Dienogest | The serum concentration of Dienogest can be decreased when it is combined with Sugammadex. |
| Norethynodrel | The serum concentration of Norethynodrel can be decreased when it is combined with Sugammadex. |
| Norgestrel | The serum concentration of Norgestrel can be decreased when it is combined with Sugammadex. |
| Gestrinone | The serum concentration of Gestrinone can be decreased when it is combined with Sugammadex. |
| Lynestrenol | The serum concentration of Lynestrenol can be decreased when it is combined with Sugammadex. |
| Chlormadinone | The serum concentration of Chlormadinone can be decreased when it is combined with Sugammadex. |
| Norgestrienone | The serum concentration of Norgestrienone can be decreased when it is combined with Sugammadex. |