Solabegron

DB06190

small molecule investigational

Deskripsi

Solabegron (GW-427,353) is a selective ?3 adrenoceptor agonist being developed for the treatment of overactive bladder and irritable bowel syndrome.

Struktur Molekul 2D

Berat 410.9
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

669 Data
Valsartan Solabegron may decrease the antihypertensive activities of Valsartan.
Ramipril Solabegron may decrease the antihypertensive activities of Ramipril.
Reserpine Solabegron may decrease the antihypertensive activities of Reserpine.
Remikiren Solabegron may decrease the antihypertensive activities of Remikiren.
Torasemide Solabegron may decrease the antihypertensive activities of Torasemide.
Isradipine Solabegron may decrease the antihypertensive activities of Isradipine.
Olmesartan Solabegron may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Solabegron may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Solabegron may decrease the antihypertensive activities of Nitroprusside.
Diltiazem Solabegron may decrease the antihypertensive activities of Diltiazem.
Minoxidil Solabegron may decrease the antihypertensive activities of Minoxidil.
Treprostinil Solabegron may decrease the antihypertensive activities of Treprostinil.
Amlodipine Solabegron may decrease the antihypertensive activities of Amlodipine.
Nimodipine Solabegron may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Solabegron may decrease the antihypertensive activities of Nisoldipine.
Bendroflumethiazide Solabegron may decrease the antihypertensive activities of Bendroflumethiazide.
Fosinopril Solabegron may decrease the antihypertensive activities of Fosinopril.
Trandolapril Solabegron may decrease the antihypertensive activities of Trandolapril.
Metolazone Solabegron may decrease the antihypertensive activities of Metolazone.
Lercanidipine Solabegron may decrease the antihypertensive activities of Lercanidipine.
Benazepril Solabegron may decrease the antihypertensive activities of Benazepril.
Bosentan Solabegron may decrease the antihypertensive activities of Bosentan.
Enalapril Solabegron may decrease the antihypertensive activities of Enalapril.
Cyclothiazide Solabegron may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Solabegron may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Solabegron may decrease the antihypertensive activities of Mecamylamine.
Losartan Solabegron may decrease the antihypertensive activities of Losartan.
Moexipril Solabegron may decrease the antihypertensive activities of Moexipril.
Eplerenone Solabegron may decrease the antihypertensive activities of Eplerenone.
Lisinopril Solabegron may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Solabegron may decrease the antihypertensive activities of Nitroglycerin.
Metyrosine Solabegron may decrease the antihypertensive activities of Metyrosine.
Hydroflumethiazide Solabegron may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Solabegron may decrease the antihypertensive activities of Cryptenamine.
Perindopril Solabegron may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Solabegron may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Solabegron may decrease the antihypertensive activities of Fenoldopam.
Indapamide Solabegron may decrease the antihypertensive activities of Indapamide.
Tadalafil Solabegron may decrease the antihypertensive activities of Tadalafil.
Eprosartan Solabegron may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Solabegron may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Solabegron may decrease the antihypertensive activities of Quinapril.
Telmisartan Solabegron may decrease the antihypertensive activities of Telmisartan.
Methyldopa Solabegron may decrease the antihypertensive activities of Methyldopa.
Hydrochlorothiazide Solabegron may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Solabegron may decrease the antihypertensive activities of Trichlormethiazide.
Irbesartan Solabegron may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Solabegron may decrease the antihypertensive activities of Nitrendipine.
Deserpidine Solabegron may decrease the antihypertensive activities of Deserpidine.
Pentolinium Solabegron may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Solabegron may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Solabegron may decrease the antihypertensive activities of Diazoxide.
Captopril Solabegron may decrease the antihypertensive activities of Captopril.
Epoprostenol Solabegron may decrease the antihypertensive activities of Epoprostenol.
Bepridil Solabegron may decrease the antihypertensive activities of Bepridil.
Hydralazine Solabegron may decrease the antihypertensive activities of Hydralazine.
Polythiazide Solabegron may decrease the antihypertensive activities of Polythiazide.
Cilazapril Solabegron may decrease the antihypertensive activities of Cilazapril.
Saprisartan Solabegron may decrease the antihypertensive activities of Saprisartan.
Spirapril Solabegron may decrease the antihypertensive activities of Spirapril.
Mibefradil Solabegron may decrease the antihypertensive activities of Mibefradil.
Tienilic acid Solabegron may decrease the antihypertensive activities of Tienilic acid.
Debrisoquine Solabegron may decrease the antihypertensive activities of Debrisoquine.
Sitaxentan Solabegron may decrease the antihypertensive activities of Sitaxentan.
Ambrisentan Solabegron may decrease the antihypertensive activities of Ambrisentan.
Diethylnorspermine Solabegron may decrease the antihypertensive activities of Diethylnorspermine.
Nilvadipine Solabegron may decrease the antihypertensive activities of Nilvadipine.
Pinacidil Solabegron may decrease the antihypertensive activities of Pinacidil.
Temocapril Solabegron may decrease the antihypertensive activities of Temocapril.
Riociguat Solabegron may decrease the antihypertensive activities of Riociguat.
Macitentan Solabegron may decrease the antihypertensive activities of Macitentan.
Hexamethonium Solabegron may decrease the antihypertensive activities of Hexamethonium.
Aliskiren Solabegron may decrease the antihypertensive activities of Aliskiren.
Nicorandil Solabegron may decrease the antihypertensive activities of Nicorandil.
Efonidipine Solabegron may decrease the antihypertensive activities of Efonidipine.
Lacidipine Solabegron may decrease the antihypertensive activities of Lacidipine.
Manidipine Solabegron may decrease the antihypertensive activities of Manidipine.
Rauwolfia serpentina root Solabegron may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Solabegron may decrease the antihypertensive activities of Enalaprilat.
Selexipag Solabegron may decrease the antihypertensive activities of Selexipag.
Angiotensin 1-7 Solabegron may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Solabegron may decrease the antihypertensive activities of Imidapril.
BQ-123 Solabegron may decrease the antihypertensive activities of BQ-123.
Tetrahydropalmatine Solabegron may decrease the antihypertensive activities of Tetrahydropalmatine.
Cicletanine Solabegron may decrease the antihypertensive activities of Cicletanine.
Dihydralazine Solabegron may decrease the antihypertensive activities of Dihydralazine.
Zofenopril Solabegron may decrease the antihypertensive activities of Zofenopril.
Guanoxan Solabegron may decrease the antihypertensive activities of Guanoxan.
Delapril Solabegron may decrease the antihypertensive activities of Delapril.
Vincamine Solabegron may decrease the antihypertensive activities of Vincamine.
Linsidomine Solabegron may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Solabegron may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Solabegron may decrease the antihypertensive activities of Tolonidine.
Endralazine Solabegron may decrease the antihypertensive activities of Endralazine.
Cadralazine Solabegron may decrease the antihypertensive activities of Cadralazine.
Cyclopenthiazide Solabegron may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Solabegron may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Solabegron may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Solabegron may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Solabegron may decrease the antihypertensive activities of Guanoclor.

Target Protein

Beta-3 adrenergic receptor ADRB3

Referensi & Sumber

Artikel (PubMed)
  • PMID: 18372395
    Grudell AB, Camilleri M, Jensen KL, Foxx-Orenstein AE, Burton DD, Ryks MD, Baxter KL, Cox DS, Dukes GE, Kelleher DL, Zinsmeister AR: Dose-response effect of a beta3-adrenergic receptor agonist, solabegron, on gastrointestinal transit, bowel function, and somatostatin levels in health. Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1114-9. doi: 10.1152/ajpgi.00051.2008. Epub 2008 Mar 27.
  • PMID: 17626794
    Hicks A, McCafferty GP, Riedel E, Aiyar N, Pullen M, Evans C, Luce TD, Coatney RW, Rivera GC, Westfall TD, Hieble JP: GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog. J Pharmacol Exp Ther. 2007 Oct;323(1):202-9. Epub 2007 Jul 12.

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Sekuens Gen/Protein (FASTA)

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