Adverse effects of oral sympathomimetics, such as Nylidrin, are common. The most frequent effects are hypertension, palpitations, nausea, anxiety, mydriasis, and restlessness/agitation L2286.
Large overdoses and severe toxicity may lead to seizures, hallucinations, agitated delirium, and tachydysrhythmias including
supraventricular tachycardia and ventricular tachycardia. Vasospasm can lead to myocardial ischemia focal cerebrovascular deficits. Severe hypertension may also result in intracranial hemorrhage or renal insufficiency. Reflex bradycardia because of significant hypertension is possible. Prolonged agitation can lead to rhabdomyolysis and hyperthermia L2286.
Nylidrin, also known as buphenine belongs to the category of drugs called vasodilators, which relax blood vessels and increase blood flow. Nylidrin is a peripheral vasodilator. Some studies show the evidence of improving cognitive impairment in selected individuals, such as geriatric patients with mild to moderate symptoms of cognitive, emotional and physical impairment L2279.
Nylidrin is utilized to treat several disorders that may benefit from increased blood flow (for example, certain mental disorders, blood vessel disease due to diabetes, frostbite, night leg cramps, and certain types of ulcers). This medication works by dilating (widening) blood vessels to help increase blood flow (improving circulation) throughout the body, including the extremities and central nervous system. This effect may help to improve memory/judgment, improve walking ability, and support the healing of frostbite/ulcers L2283.
FDA has considered nylidrin as "lacking substantial evidence of effectiveness" in cerebral ischemia, cerebral arteriosclerosis, and other cerebral circulatory insufficiencies. Therefore, the FDA has withdrawn nylidrin from the U.S. market L2286.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Ceritinib | Nylidrin may increase the bradycardic activities of Ceritinib. |
| Ivabradine | Nylidrin may increase the bradycardic activities of Ivabradine. |
| Ruxolitinib | Ruxolitinib may increase the bradycardic activities of Nylidrin. |
| Reserpine | Nylidrin may decrease the antihypertensive activities of Reserpine. |
| Remikiren | Nylidrin may decrease the antihypertensive activities of Remikiren. |
| Torasemide | Nylidrin may decrease the antihypertensive activities of Torasemide. |
| Chlorthalidone | Nylidrin may decrease the antihypertensive activities of Chlorthalidone. |
| Minoxidil | Nylidrin may decrease the antihypertensive activities of Minoxidil. |
| Treprostinil | Nylidrin may decrease the antihypertensive activities of Treprostinil. |
| Metolazone | Nylidrin may decrease the antihypertensive activities of Metolazone. |
| Cyclothiazide | Nylidrin may decrease the antihypertensive activities of Cyclothiazide. |
| Candoxatril | Nylidrin may decrease the antihypertensive activities of Candoxatril. |
| Mecamylamine | Nylidrin may decrease the antihypertensive activities of Mecamylamine. |
| Metyrosine | Nylidrin may decrease the antihypertensive activities of Metyrosine. |
| Hydroflumethiazide | Nylidrin may decrease the antihypertensive activities of Hydroflumethiazide. |
| Cryptenamine | Nylidrin may decrease the antihypertensive activities of Cryptenamine. |
| Fenoldopam | Nylidrin may decrease the antihypertensive activities of Fenoldopam. |
| Chlorothiazide | Nylidrin may decrease the antihypertensive activities of Chlorothiazide. |
| Hydrochlorothiazide | Nylidrin may decrease the antihypertensive activities of Hydrochlorothiazide. |
| Trichlormethiazide | Nylidrin may decrease the antihypertensive activities of Trichlormethiazide. |
| Deserpidine | Nylidrin may decrease the antihypertensive activities of Deserpidine. |
| Pentolinium | Nylidrin may decrease the antihypertensive activities of Pentolinium. |
| Trimethaphan | Nylidrin may decrease the antihypertensive activities of Trimethaphan. |
| Diazoxide | Nylidrin may decrease the antihypertensive activities of Diazoxide. |
| Epoprostenol | Nylidrin may decrease the antihypertensive activities of Epoprostenol. |
| Polythiazide | Nylidrin may decrease the antihypertensive activities of Polythiazide. |
| Tienilic acid | Nylidrin may decrease the antihypertensive activities of Tienilic acid. |
| Debrisoquine | Nylidrin may decrease the antihypertensive activities of Debrisoquine. |
| Diethylnorspermine | Nylidrin may decrease the antihypertensive activities of Diethylnorspermine. |
| Hexamethonium | Nylidrin may decrease the antihypertensive activities of Hexamethonium. |
| Rauwolfia serpentina root | Nylidrin may decrease the antihypertensive activities of Rauwolfia serpentina root. |
| Angiotensin 1-7 | Nylidrin may decrease the antihypertensive activities of Angiotensin 1-7. |
| BQ-123 | Nylidrin may decrease the antihypertensive activities of BQ-123. |
| Dihydralazine | Nylidrin may decrease the antihypertensive activities of Dihydralazine. |
| Guanoxan | Nylidrin may decrease the antihypertensive activities of Guanoxan. |
| Vincamine | Nylidrin may decrease the antihypertensive activities of Vincamine. |
| Linsidomine | Nylidrin may decrease the antihypertensive activities of Linsidomine. |
| Guanoxabenz | Nylidrin may decrease the antihypertensive activities of Guanoxabenz. |
| Tolonidine | Nylidrin may decrease the antihypertensive activities of Tolonidine. |
| Endralazine | Nylidrin may decrease the antihypertensive activities of Endralazine. |
| Cadralazine | Nylidrin may decrease the antihypertensive activities of Cadralazine. |
| Cyclopenthiazide | Nylidrin may decrease the antihypertensive activities of Cyclopenthiazide. |
| Bietaserpine | Nylidrin may decrease the antihypertensive activities of Bietaserpine. |
| Guanazodine | Nylidrin may decrease the antihypertensive activities of Guanazodine. |
| Methoserpidine | Nylidrin may decrease the antihypertensive activities of Methoserpidine. |
| Guanoclor | Nylidrin may decrease the antihypertensive activities of Guanoclor. |
| Muzolimine | Nylidrin may decrease the antihypertensive activities of Muzolimine. |
| Xipamide | Nylidrin may decrease the antihypertensive activities of Xipamide. |
| Tocopherylquinone | Nylidrin may decrease the antihypertensive activities of Tocopherylquinone. |
| Furosemide | Nylidrin may decrease the antihypertensive activities of Furosemide. |
| Bosentan | Nylidrin may decrease the antihypertensive activities of Bosentan. |
| Indapamide | Nylidrin may decrease the antihypertensive activities of Indapamide. |
| Tadalafil | Nylidrin may decrease the antihypertensive activities of Tadalafil. |
| Guanfacine | Nylidrin may decrease the antihypertensive activities of Guanfacine. |
| Hydralazine | Nylidrin may decrease the antihypertensive activities of Hydralazine. |
| Sitaxentan | Nylidrin may decrease the antihypertensive activities of Sitaxentan. |
| Ambrisentan | Nylidrin may decrease the antihypertensive activities of Ambrisentan. |
| Pinacidil | Nylidrin may decrease the antihypertensive activities of Pinacidil. |
| Riociguat | Nylidrin may decrease the antihypertensive activities of Riociguat. |
| Macitentan | Nylidrin may decrease the antihypertensive activities of Macitentan. |
| Selexipag | Nylidrin may decrease the antihypertensive activities of Selexipag. |
| Levamlodipine | Nylidrin may decrease the antihypertensive activities of Levamlodipine. |
| Buthiazide | Nylidrin may decrease the antihypertensive activities of Buthiazide. |
| Atomoxetine | The risk or severity of hypertension can be increased when Atomoxetine is combined with Nylidrin. |
| Linezolid | The risk or severity of hypertension can be increased when Linezolid is combined with Nylidrin. |
| Desmopressin | The risk or severity of hypertension can be increased when Desmopressin is combined with Nylidrin. |
| Bethanidine | Nylidrin may decrease the antihypertensive activities of Bethanidine. |
| Isoetharine | The risk or severity of hypertension can be increased when Isoetharine is combined with Nylidrin. |
| Etomidate | The risk or severity of hypertension can be increased when Etomidate is combined with Nylidrin. |
| Zolmitriptan | The risk or severity of hypertension can be increased when Zolmitriptan is combined with Nylidrin. |
| Methylphenidate | The risk or severity of hypertension can be increased when Methylphenidate is combined with Nylidrin. |
| Doxapram | The risk or severity of hypertension can be increased when Doxapram is combined with Nylidrin. |
| Furazolidone | The risk or severity of hypertension can be increased when Furazolidone is combined with Nylidrin. |
| Guanabenz | Nylidrin may decrease the antihypertensive activities of Guanabenz. |
| Sumatriptan | The risk or severity of hypertension can be increased when Sumatriptan is combined with Nylidrin. |
| Isoflurane | The risk or severity of hypertension can be increased when Isoflurane is combined with Nylidrin. |
| Minaprine | The risk or severity of hypertension can be increased when Minaprine is combined with Nylidrin. |
| Propofol | The risk or severity of hypertension can be increased when Propofol is combined with Nylidrin. |
| Bitolterol | The risk or severity of hypertension can be increased when Bitolterol is combined with Nylidrin. |
| Naratriptan | The risk or severity of hypertension can be increased when Naratriptan is combined with Nylidrin. |
| Rizatriptan | The risk or severity of hypertension can be increased when Rizatriptan is combined with Nylidrin. |
| Frovatriptan | The risk or severity of hypertension can be increased when Frovatriptan is combined with Nylidrin. |
| Arbutamine | The risk or severity of hypertension can be increased when Arbutamine is combined with Nylidrin. |
| Moclobemide | The risk or severity of hypertension can be increased when Moclobemide is combined with Nylidrin. |
| Desflurane | The risk or severity of hypertension can be increased when Desflurane is combined with Nylidrin. |
| Isocarboxazid | The risk or severity of hypertension can be increased when Isocarboxazid is combined with Nylidrin. |
| Arformoterol | The risk or severity of hypertension can be increased when Arformoterol is combined with Nylidrin. |
| Pirbuterol | The risk or severity of hypertension can be increased when Pirbuterol is combined with Nylidrin. |
| Ephedra sinica root | The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Nylidrin. |
| Rasagiline | The risk or severity of hypertension can be increased when Rasagiline is combined with Nylidrin. |
| Bambuterol | The risk or severity of hypertension can be increased when Bambuterol is combined with Nylidrin. |
| 4-Methoxyamphetamine | The risk or severity of hypertension can be increased when 4-Methoxyamphetamine is combined with Nylidrin. |
| Phendimetrazine | The risk or severity of hypertension can be increased when Phendimetrazine is combined with Nylidrin. |
| Pargyline | Nylidrin may decrease the antihypertensive activities of Pargyline. |
| Epicaptopril | The risk or severity of hypertension can be increased when Epicaptopril is combined with Nylidrin. |
| Taxifolin | The risk or severity of hypertension can be increased when Taxifolin is combined with Nylidrin. |
| Clorgiline | The risk or severity of hypertension can be increased when Clorgiline is combined with Nylidrin. |
| 1-benzylimidazole | The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Nylidrin. |
| Iproniazid | The risk or severity of hypertension can be increased when Iproniazid is combined with Nylidrin. |
| Nialamide | The risk or severity of hypertension can be increased when Nialamide is combined with Nylidrin. |