Peringatan Keamanan

Oral rat LD50: 780mg/kg

Mianserin

DB06148

small molecule approved investigational

Deskripsi

A tetracyclic compound with antidepressant effects. Mianserin was previously available internationally, however in most markets it has been phased out in favour of mirtazapine.

Struktur Molekul 2D

Berat 264.3648
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 10-17 hours
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Absorbed following oral administration.

Metabolisme

Hepatic.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1548 Data
Deferasirox The serum concentration of Mianserin can be increased when it is combined with Deferasirox.
Peginterferon alfa-2b The serum concentration of Mianserin can be increased when it is combined with Peginterferon alfa-2b.
Leflunomide The serum concentration of Mianserin can be decreased when it is combined with Leflunomide.
Teriflunomide The serum concentration of Mianserin can be decreased when it is combined with Teriflunomide.
Valsartan Mianserin may decrease the antihypertensive activities of Valsartan.
Ramipril Mianserin may decrease the antihypertensive activities of Ramipril.
Remikiren Mianserin may decrease the antihypertensive activities of Remikiren.
Torasemide Mianserin may decrease the antihypertensive activities of Torasemide.
Guanadrel Mianserin may decrease the antihypertensive activities of Guanadrel.
Olmesartan Mianserin may decrease the antihypertensive activities of Olmesartan.
Chlorthalidone Mianserin may decrease the antihypertensive activities of Chlorthalidone.
Nitroprusside Mianserin may decrease the antihypertensive activities of Nitroprusside.
Minoxidil Mianserin may decrease the antihypertensive activities of Minoxidil.
Treprostinil Mianserin may decrease the antihypertensive activities of Treprostinil.
Bendroflumethiazide Mianserin may decrease the antihypertensive activities of Bendroflumethiazide.
Prazosin Mianserin may decrease the antihypertensive activities of Prazosin.
Fosinopril Mianserin may decrease the antihypertensive activities of Fosinopril.
Trandolapril Mianserin may decrease the antihypertensive activities of Trandolapril.
Metolazone Mianserin may decrease the antihypertensive activities of Metolazone.
Benazepril Mianserin may decrease the antihypertensive activities of Benazepril.
Cyclothiazide Mianserin may decrease the antihypertensive activities of Cyclothiazide.
Candoxatril Mianserin may decrease the antihypertensive activities of Candoxatril.
Mecamylamine Mianserin may decrease the antihypertensive activities of Mecamylamine.
Moexipril Mianserin may decrease the antihypertensive activities of Moexipril.
Lisinopril Mianserin may decrease the antihypertensive activities of Lisinopril.
Nitroglycerin Mianserin may decrease the antihypertensive activities of Nitroglycerin.
Hydroflumethiazide Mianserin may decrease the antihypertensive activities of Hydroflumethiazide.
Cryptenamine Mianserin may decrease the antihypertensive activities of Cryptenamine.
Perindopril Mianserin may decrease the antihypertensive activities of Perindopril.
Candesartan cilexetil Mianserin may decrease the antihypertensive activities of Candesartan cilexetil.
Fenoldopam Mianserin may decrease the antihypertensive activities of Fenoldopam.
Eprosartan Mianserin may decrease the antihypertensive activities of Eprosartan.
Chlorothiazide Mianserin may decrease the antihypertensive activities of Chlorothiazide.
Quinapril Mianserin may decrease the antihypertensive activities of Quinapril.
Telmisartan Mianserin may decrease the antihypertensive activities of Telmisartan.
Hydrochlorothiazide Mianserin may decrease the antihypertensive activities of Hydrochlorothiazide.
Trichlormethiazide Mianserin may decrease the antihypertensive activities of Trichlormethiazide.
Deserpidine Mianserin may decrease the antihypertensive activities of Deserpidine.
Pentolinium Mianserin may decrease the antihypertensive activities of Pentolinium.
Trimethaphan Mianserin may decrease the antihypertensive activities of Trimethaphan.
Diazoxide Mianserin may decrease the antihypertensive activities of Diazoxide.
Bretylium Mianserin may decrease the antihypertensive activities of Bretylium.
Terazosin Mianserin may decrease the antihypertensive activities of Terazosin.
Epoprostenol Mianserin may decrease the antihypertensive activities of Epoprostenol.
Polythiazide Mianserin may decrease the antihypertensive activities of Polythiazide.
Cilazapril Mianserin may decrease the antihypertensive activities of Cilazapril.
Saprisartan Mianserin may decrease the antihypertensive activities of Saprisartan.
Spirapril Mianserin may decrease the antihypertensive activities of Spirapril.
Dexpropranolol Mianserin may decrease the antihypertensive activities of Dexpropranolol.
Tienilic acid Mianserin may decrease the antihypertensive activities of Tienilic acid.
Diethylnorspermine Mianserin may decrease the antihypertensive activities of Diethylnorspermine.
Temocapril Mianserin may decrease the antihypertensive activities of Temocapril.
Trimazosin Mianserin may decrease the antihypertensive activities of Trimazosin.
Nicorandil Mianserin may decrease the antihypertensive activities of Nicorandil.
Rauwolfia serpentina root Mianserin may decrease the antihypertensive activities of Rauwolfia serpentina root.
Enalaprilat Mianserin may decrease the antihypertensive activities of Enalaprilat.
Angiotensin 1-7 Mianserin may decrease the antihypertensive activities of Angiotensin 1-7.
Imidapril Mianserin may decrease the antihypertensive activities of Imidapril.
BQ-123 Mianserin may decrease the antihypertensive activities of BQ-123.
Cicletanine Mianserin may decrease the antihypertensive activities of Cicletanine.
Zofenopril Mianserin may decrease the antihypertensive activities of Zofenopril.
Guanoxan Mianserin may decrease the antihypertensive activities of Guanoxan.
Delapril Mianserin may decrease the antihypertensive activities of Delapril.
Vincamine Mianserin may decrease the antihypertensive activities of Vincamine.
Linsidomine Mianserin may decrease the antihypertensive activities of Linsidomine.
Guanoxabenz Mianserin may decrease the antihypertensive activities of Guanoxabenz.
Tolonidine Mianserin may decrease the antihypertensive activities of Tolonidine.
Endralazine Mianserin may decrease the antihypertensive activities of Endralazine.
Cadralazine Mianserin may decrease the antihypertensive activities of Cadralazine.
Cyclopenthiazide Mianserin may decrease the antihypertensive activities of Cyclopenthiazide.
Bietaserpine Mianserin may decrease the antihypertensive activities of Bietaserpine.
Guanazodine Mianserin may decrease the antihypertensive activities of Guanazodine.
Methoserpidine Mianserin may decrease the antihypertensive activities of Methoserpidine.
Guanoclor Mianserin may decrease the antihypertensive activities of Guanoclor.
Muzolimine Mianserin may decrease the antihypertensive activities of Muzolimine.
Xipamide Mianserin may decrease the antihypertensive activities of Xipamide.
Candesartan Mianserin may decrease the antihypertensive activities of Candesartan.
Tocopherylquinone Mianserin may decrease the antihypertensive activities of Tocopherylquinone.
Benazeprilat Mianserin may decrease the antihypertensive activities of Benazeprilat.
Fosinoprilat Mianserin may decrease the antihypertensive activities of Fosinoprilat.
Ramiprilat Mianserin may decrease the antihypertensive activities of Ramiprilat.
Perindoprilat Mianserin may decrease the antihypertensive activities of Perindoprilat.
Quinaprilat Mianserin may decrease the antihypertensive activities of Quinaprilat.
Furosemide Mianserin may decrease the antihypertensive activities of Furosemide.
Enalapril Mianserin may decrease the antihypertensive activities of Enalapril.
Captopril Mianserin may decrease the antihypertensive activities of Captopril.
Nimodipine Mianserin may decrease the antihypertensive activities of Nimodipine.
Nisoldipine Mianserin may decrease the antihypertensive activities of Nisoldipine.
Bosentan Mianserin may decrease the antihypertensive activities of Bosentan.
Doxazosin Mianserin may decrease the antihypertensive activities of Doxazosin.
Bisoprolol Mianserin may decrease the antihypertensive activities of Bisoprolol.
Losartan Mianserin may decrease the antihypertensive activities of Losartan.
Eplerenone Mianserin may decrease the antihypertensive activities of Eplerenone.
Indapamide Mianserin may decrease the antihypertensive activities of Indapamide.
Tadalafil Mianserin may decrease the antihypertensive activities of Tadalafil.
Irbesartan Mianserin may decrease the antihypertensive activities of Irbesartan.
Nitrendipine Mianserin may decrease the antihypertensive activities of Nitrendipine.
Guanethidine Mianserin may decrease the antihypertensive activities of Guanethidine.
Hydralazine Mianserin may decrease the antihypertensive activities of Hydralazine.
Nebivolol Mianserin may decrease the antihypertensive activities of Nebivolol.

Target Protein

Alpha-2A adrenergic receptor ADRA2A
5-hydroxytryptamine receptor 2A HTR2A
5-hydroxytryptamine receptor 2C HTR2C
Histamine H1 receptor HRH1
Sodium-dependent noradrenaline transporter SLC6A2
Sodium-dependent serotonin transporter SLC6A4
Histamine H4 receptor HRH4
5-hydroxytryptamine receptor 1A HTR1A
Alpha-2C adrenergic receptor ADRA2C
5-hydroxytryptamine receptor 2B HTR2B
5-hydroxytryptamine receptor 1F HTR1F
Alpha-2B adrenergic receptor ADRA2B
D(3) dopamine receptor DRD3
Kappa-type opioid receptor OPRK1
Sodium-dependent dopamine transporter SLC6A3
5-hydroxytryptamine receptor 7 HTR7
D(2) dopamine receptor DRD2
5-hydroxytryptamine receptor 6 HTR6
Alpha-1 adrenergic receptors ADRA1A
D(1) dopamine receptor DRD1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 8764331
    Koyama E, Chiba K, Tani M, Ishizaki T: Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers. J Pharmacol Exp Ther. 1996 Jul;278(1):21-30.
  • PMID: 8627567
    de Boer TH, Nefkens F, van Helvoirt A, van Delft AM: Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan. J Pharmacol Exp Ther. 1996 May;277(2):852-60.
  • PMID: 9232538
    Kelder J, Funke C, De Boer T, Delbressine L, Leysen D, Nickolson V: A comparison of the physicochemical and biological properties of mirtazapine and mianserin. J Pharm Pharmacol. 1997 Apr;49(4):403-11.
  • PMID: 7002830
    Petrie WM, Wilson WH, Ban TA, Guy W, Schaffer JD: Mianserin: determination of therapeutic dose range. Int Pharmacopsychiatry. 1980;15(2):111-7. doi: 10.1159/000468421.
  • PMID: 359311
    Brogden RN, Heel RC, Speight TM, Avery GS: Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs. 1978 Oct;16(4):273-301. doi: 10.2165/00003495-197816040-00001.

Contoh Produk & Brand

Produk: 0 • International brands: 6
International Brands
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  • Depnon
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  • Lumin
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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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