Sertindole, a neuroleptic, is one of the newer antipsychotic medications available. Serdolect is developed by the Danish pharmaceutical company H. Lundbeck. It is a phenylindole derivative used in the treatment of schizophrenia. It was first marketed in 1996 in several European countries before being withdrawn two years later because of numerous cardiac adverse effects. It has once again been approved and should soon be available on the French and Australian market.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Buprenorphine | Sertindole may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Sertindole. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Sertindole. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Sertindole. |
| Hydrocodone | Sertindole may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Magnesium sulfate | The therapeutic efficacy of Sertindole can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Sertindole may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Sertindole may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Sertindole. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Sertindole. |
| Orphenadrine | Sertindole may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Sertindole may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Sertindole. |
| Rotigotine | Sertindole may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Sertindole. |
| Sodium oxybate | Sertindole may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Suvorexant | Sertindole may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Sertindole. |
| Thalidomide | Sertindole may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Sertindole may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Amisulpride | Sertindole may increase the antipsychotic activities of Amisulpride. |
| Methylphenidate | The risk or severity of adverse effects can be increased when Sertindole is combined with Methylphenidate. |
| Metoclopramide | The risk or severity of adverse effects can be increased when Metoclopramide is combined with Sertindole. |
| Quinagolide | The therapeutic efficacy of Quinagolide can be decreased when used in combination with Sertindole. |
| Sulpiride | Sertindole may increase the antipsychotic activities of Sulpiride. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Sertindole. |
| Lithium citrate | Lithium citrate may increase the neurotoxic activities of Sertindole. |
| Lithium hydroxide | Lithium hydroxide may increase the neurotoxic activities of Sertindole. |
| Mequitazine | Sertindole may increase the arrhythmogenic activities of Mequitazine. |
| Linezolid | The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Sertindole. |
| Dicoumarol | The risk or severity of adverse effects can be increased when Sertindole is combined with Dicoumarol. |
| Phenindione | The risk or severity of adverse effects can be increased when Sertindole is combined with Phenindione. |
| Coumarin | The risk or severity of adverse effects can be increased when Sertindole is combined with Coumarin. |
| Tioclomarol | The risk or severity of adverse effects can be increased when Sertindole is combined with Tioclomarol. |
| Warfarin | The risk or severity of adverse effects can be increased when Sertindole is combined with Warfarin. |
| Phenprocoumon | The risk or severity of adverse effects can be increased when Sertindole is combined with Phenprocoumon. |
| Acenocoumarol | The risk or severity of adverse effects can be increased when Sertindole is combined with Acenocoumarol. |
| 4-hydroxycoumarin | The risk or severity of adverse effects can be increased when Sertindole is combined with 4-hydroxycoumarin. |
| (R)-warfarin | The risk or severity of adverse effects can be increased when Sertindole is combined with (R)-warfarin. |
| Ethyl biscoumacetate | The risk or severity of adverse effects can be increased when Sertindole is combined with Ethyl biscoumacetate. |
| Fluindione | The risk or severity of adverse effects can be increased when Sertindole is combined with Fluindione. |
| Clorindione | The risk or severity of adverse effects can be increased when Sertindole is combined with Clorindione. |
| Diphenadione | The risk or severity of adverse effects can be increased when Sertindole is combined with Diphenadione. |
| (S)-Warfarin | The risk or severity of adverse effects can be increased when Sertindole is combined with (S)-Warfarin. |
| Mirabegron | The serum concentration of Sertindole can be increased when it is combined with Mirabegron. |
| Mirtazapine | Sertindole may increase the serotonergic activities of Mirtazapine. |
| Ethanol | Sertindole may increase the central nervous system depressant (CNS depressant) activities of Ethanol. |
| Azelastine | Sertindole may increase the central nervous system depressant (CNS depressant) activities of Azelastine. |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Sertindole. |
| Zimelidine | The risk or severity of adverse effects can be increased when Sertindole is combined with Zimelidine. |
| Dapoxetine | The risk or severity of adverse effects can be increased when Sertindole is combined with Dapoxetine. |
| Seproxetine | The risk or severity of adverse effects can be increased when Sertindole is combined with Seproxetine. |
| Citalopram | The risk or severity of QTc prolongation can be increased when Sertindole is combined with Citalopram. |
| Sertraline | The risk or severity of adverse effects can be increased when Sertindole is combined with Sertraline. |
| Sibutramine | The risk or severity of adverse effects can be increased when Sertindole is combined with Sibutramine. |
| Milnacipran | The risk or severity of adverse effects can be increased when Sertindole is combined with Milnacipran. |
| Desvenlafaxine | The risk or severity of serotonin syndrome can be increased when Desvenlafaxine is combined with Sertindole. |
| Levomilnacipran | The risk or severity of serotonin syndrome can be increased when Sertindole is combined with Levomilnacipran. |
| Indalpine | The risk or severity of adverse effects can be increased when Sertindole is combined with Indalpine. |
| Alaproclate | The risk or severity of adverse effects can be increased when Sertindole is combined with Alaproclate. |
| Carbidopa | The therapeutic efficacy of Carbidopa can be decreased when used in combination with Sertindole. |
| Cabergoline | The therapeutic efficacy of Cabergoline can be decreased when used in combination with Sertindole. |
| Tolcapone | The therapeutic efficacy of Tolcapone can be decreased when used in combination with Sertindole. |
| Metixene | The therapeutic efficacy of Metixene can be decreased when used in combination with Sertindole. |
| Trihexyphenidyl | The therapeutic efficacy of Trihexyphenidyl can be decreased when used in combination with Sertindole. |
| Procyclidine | The therapeutic efficacy of Procyclidine can be decreased when used in combination with Sertindole. |
| Profenamine | The therapeutic efficacy of Profenamine can be decreased when used in combination with Sertindole. |
| Entacapone | The therapeutic efficacy of Entacapone can be decreased when used in combination with Sertindole. |
| Lisuride | The therapeutic efficacy of Lisuride can be decreased when used in combination with Sertindole. |
| Apomorphine | The therapeutic efficacy of Apomorphine can be decreased when used in combination with Sertindole. |
| Biperiden | The therapeutic efficacy of Biperiden can be decreased when used in combination with Sertindole. |
| Amantadine | The therapeutic efficacy of Amantadine can be decreased when used in combination with Sertindole. |
| Memantine | The therapeutic efficacy of Memantine can be decreased when used in combination with Sertindole. |
| Pergolide | The therapeutic efficacy of Pergolide can be decreased when used in combination with Sertindole. |
| Levodopa | The therapeutic efficacy of Levodopa can be decreased when used in combination with Sertindole. |
| Rasagiline | The therapeutic efficacy of Rasagiline can be decreased when used in combination with Sertindole. |
| 3,5-Dinitrocatechol | The therapeutic efficacy of 3,5-Dinitrocatechol can be decreased when used in combination with Sertindole. |
| Etilevodopa | The therapeutic efficacy of Etilevodopa can be decreased when used in combination with Sertindole. |
| Safinamide | The therapeutic efficacy of Safinamide can be decreased when used in combination with Sertindole. |
| Ifenprodil | The therapeutic efficacy of Ifenprodil can be decreased when used in combination with Sertindole. |
| Dexetimide | The therapeutic efficacy of Dexetimide can be decreased when used in combination with Sertindole. |
| Opicapone | The therapeutic efficacy of Opicapone can be decreased when used in combination with Sertindole. |
| Piribedil | The therapeutic efficacy of Piribedil can be decreased when used in combination with Sertindole. |
| Benserazide | The therapeutic efficacy of Benserazide can be decreased when used in combination with Sertindole. |
| Tropatepine | The therapeutic efficacy of Tropatepine can be decreased when used in combination with Sertindole. |
| Melevodopa | The therapeutic efficacy of Melevodopa can be decreased when used in combination with Sertindole. |
| Dihydroergocryptine | The therapeutic efficacy of Dihydroergocryptine can be decreased when used in combination with Sertindole. |
| Phenglutarimide | The therapeutic efficacy of Phenglutarimide can be decreased when used in combination with Sertindole. |
| Mazaticol | The therapeutic efficacy of Mazaticol can be decreased when used in combination with Sertindole. |
| Etybenzatropine | The therapeutic efficacy of Etybenzatropine can be decreased when used in combination with Sertindole. |
| Budipine | The therapeutic efficacy of Budipine can be decreased when used in combination with Sertindole. |
| Bornaprine | The therapeutic efficacy of Bornaprine can be decreased when used in combination with Sertindole. |
| Etanautine | The therapeutic efficacy of Etanautine can be decreased when used in combination with Sertindole. |
| Dexpramipexole | The therapeutic efficacy of Dexpramipexole can be decreased when used in combination with Sertindole. |
| Bromocriptine | The therapeutic efficacy of Bromocriptine can be decreased when used in combination with Sertindole. |
| Methylene blue | Sertindole may increase the serotonergic activities of Methylene blue. |
| Trospium | The metabolism of Sertindole can be decreased when combined with Trospium. |
| Cyproheptadine | The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Sertindole. |
| Propiomazine | The risk or severity of CNS depression can be increased when Propiomazine is combined with Sertindole. |
| Tolterodine | The metabolism of Sertindole can be decreased when combined with Tolterodine. |