Bisegliptin is a compound for the treatment of type 2 diabetes. It is an orally active, dipeptidyl peptidase-IV (DPPIV) inhibitor which lowers blood glucose levels by blocking the degradation of the hormone GLP-1 thereby stimulating glucose-dependent insulin secretion and lowering blood glucose levels without hypoglycemic effects.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Pegvisomant | The risk or severity of hypoglycemia can be increased when Pegvisomant is combined with Bisegliptin. |
| Lipoic acid | The risk or severity of hypoglycemia can be increased when Lipoic acid is combined with Bisegliptin. |
| Moxifloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Moxifloxacin. |
| Grepafloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Grepafloxacin. |
| Enoxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Enoxacin. |
| Pefloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Pefloxacin. |
| Ciprofloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Ciprofloxacin. |
| Trovafloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Trovafloxacin. |
| Nalidixic acid | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Nalidixic acid. |
| Rosoxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Rosoxacin. |
| Cinoxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Cinoxacin. |
| Lomefloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Lomefloxacin. |
| Gatifloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Gatifloxacin. |
| Norfloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Norfloxacin. |
| Levofloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Levofloxacin. |
| Gemifloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Gemifloxacin. |
| Ofloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Ofloxacin. |
| Sparfloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Sparfloxacin. |
| Temafloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Temafloxacin. |
| Fleroxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Fleroxacin. |
| Technetium Tc-99m ciprofloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Technetium Tc-99m ciprofloxacin. |
| Garenoxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Garenoxacin. |
| Nemonoxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Nemonoxacin. |
| Flumequine | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Flumequine. |
| Enrofloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Enrofloxacin. |
| Orbifloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Orbifloxacin. |
| Sarafloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Sarafloxacin. |
| Difloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Difloxacin. |
| Pazufloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Pazufloxacin. |
| Prulifloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Prulifloxacin. |
| Delafloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Delafloxacin. |
| Sitafloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Sitafloxacin. |
| Oxolinic acid | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Oxolinic acid. |
| Rufloxacin | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Rufloxacin. |
| Pipemidic acid | The therapeutic efficacy of Bisegliptin can be increased when used in combination with Pipemidic acid. |
| Methyclothiazide | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Methyclothiazide. |
| Chlorthalidone | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Chlorthalidone. |
| Bendroflumethiazide | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Bendroflumethiazide. |
| Metolazone | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Metolazone. |
| Benzthiazide | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Benzthiazide. |
| Hydroflumethiazide | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Hydroflumethiazide. |
| Indapamide | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Indapamide. |
| Chlorothiazide | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Chlorothiazide. |
| Hydrochlorothiazide | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Hydrochlorothiazide. |
| Trichlormethiazide | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Trichlormethiazide. |
| Polythiazide | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Polythiazide. |
| Quinethazone | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Quinethazone. |
| Cyclopenthiazide | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Cyclopenthiazide. |
| Epitizide | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Epitizide. |
| Amitriptyline | Amitriptyline may decrease the hypoglycemic activities of Bisegliptin. |
| Protriptyline | Protriptyline may decrease the hypoglycemic activities of Bisegliptin. |
| Imipramine | Imipramine may decrease the hypoglycemic activities of Bisegliptin. |
| Nortriptyline | Nortriptyline may decrease the hypoglycemic activities of Bisegliptin. |
| Amoxapine | Amoxapine may decrease the hypoglycemic activities of Bisegliptin. |
| Trimipramine | Trimipramine may decrease the hypoglycemic activities of Bisegliptin. |
| Doxepin | Doxepin may decrease the hypoglycemic activities of Bisegliptin. |
| Desipramine | Desipramine may decrease the hypoglycemic activities of Bisegliptin. |
| Clomipramine | Clomipramine may decrease the hypoglycemic activities of Bisegliptin. |
| Amineptine | Amineptine may decrease the hypoglycemic activities of Bisegliptin. |
| Dimetacrine | Dimetacrine may decrease the hypoglycemic activities of Bisegliptin. |
| Butriptyline | Butriptyline may decrease the hypoglycemic activities of Bisegliptin. |
| Dosulepin | Dosulepin may decrease the hypoglycemic activities of Bisegliptin. |
| Tianeptine | Tianeptine may decrease the hypoglycemic activities of Bisegliptin. |
| Oxaprotiline | Oxaprotiline may decrease the hypoglycemic activities of Bisegliptin. |
| Opipramol | Opipramol may decrease the hypoglycemic activities of Bisegliptin. |
| Amitriptylinoxide | Amitriptylinoxide may decrease the hypoglycemic activities of Bisegliptin. |
| Dibenzepin | Dibenzepin may decrease the hypoglycemic activities of Bisegliptin. |
| Quinupramine | Quinupramine may decrease the hypoglycemic activities of Bisegliptin. |
| Melitracen | Melitracen may decrease the hypoglycemic activities of Bisegliptin. |
| Lofepramine | Lofepramine may decrease the hypoglycemic activities of Bisegliptin. |
| Iprindole | Iprindole may decrease the hypoglycemic activities of Bisegliptin. |
| Imipramine oxide | Imipramine oxide may decrease the hypoglycemic activities of Bisegliptin. |
| Glimepiride | Bisegliptin may increase the hypoglycemic activities of Glimepiride. |
| Acetohexamide | Bisegliptin may increase the hypoglycemic activities of Acetohexamide. |
| Chlorpropamide | Bisegliptin may increase the hypoglycemic activities of Chlorpropamide. |
| Tolazamide | Bisegliptin may increase the hypoglycemic activities of Tolazamide. |
| Glyburide | Bisegliptin may increase the hypoglycemic activities of Glyburide. |
| Glipizide | Bisegliptin may increase the hypoglycemic activities of Glipizide. |
| Gliclazide | Bisegliptin may increase the hypoglycemic activities of Gliclazide. |
| Tolbutamide | Bisegliptin may increase the hypoglycemic activities of Tolbutamide. |
| Gliquidone | Bisegliptin may increase the hypoglycemic activities of Gliquidone. |
| Glisoxepide | Bisegliptin may increase the hypoglycemic activities of Glisoxepide. |
| Glibornuride | Bisegliptin may increase the hypoglycemic activities of Glibornuride. |
| Carbutamide | Bisegliptin may increase the hypoglycemic activities of Carbutamide. |
| Metahexamide | Bisegliptin may increase the hypoglycemic activities of Metahexamide. |
| Dapagliflozin | Dapagliflozin may increase the hypoglycemic activities of Bisegliptin. |
| Canagliflozin | Canagliflozin may increase the hypoglycemic activities of Bisegliptin. |
| Leuprolide | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Leuprolide. |
| Goserelin | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Goserelin. |
| Nelfinavir | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Nelfinavir. |
| Indinavir | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Indinavir. |
| Ziprasidone | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Ziprasidone. |
| Etonogestrel | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Etonogestrel. |
| Desogestrel | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Desogestrel. |
| Olanzapine | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Olanzapine. |
| Megestrol acetate | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Megestrol acetate. |
| Clozapine | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Clozapine. |
| Levonorgestrel | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Levonorgestrel. |
| Progesterone | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Progesterone. |
| Chlorpromazine | The therapeutic efficacy of Bisegliptin can be decreased when used in combination with Chlorpromazine. |