Dovitinib is an orally active small molecule that exhibits potent inhibitory activity against multiple RTKs involved in tumor growth and angiogenesis. Preclinical data show that dovitinib works to inhibit multiple kinases associated with different cancers, including acute myeloid leukemia (AML) and multiple myeloma. Chiron currently has three ongoing Phase I clinical trials for dovitinib.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Lomitapide | The metabolism of Lomitapide can be decreased when combined with Dovitinib. |
| Cilostazol | The serum concentration of Cilostazol can be increased when it is combined with Dovitinib. |
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with Dovitinib. |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with Dovitinib. |
| Colchicine | The metabolism of Colchicine can be decreased when combined with Dovitinib. |
| Iloperidone | The metabolism of Iloperidone can be decreased when combined with Dovitinib. |
| Retapamulin | The metabolism of Retapamulin can be decreased when combined with Dovitinib. |
| Tofacitinib | The metabolism of Tofacitinib can be decreased when combined with Dovitinib. |
| Vardenafil | The metabolism of Vardenafil can be decreased when combined with Dovitinib. |
| Eszopiclone | The metabolism of Eszopiclone can be decreased when combined with Dovitinib. |
| Zopiclone | The metabolism of Zopiclone can be decreased when combined with Dovitinib. |
| Lovastatin | The metabolism of Lovastatin can be decreased when combined with Dovitinib. |
| Acetaminophen | The serum concentration of Acetaminophen can be increased when it is combined with Dovitinib. |
| Propacetamol | The serum concentration of Propacetamol can be increased when it is combined with Dovitinib. |
| Alfuzosin | The metabolism of Alfuzosin can be decreased when combined with Dovitinib. |
| Alprazolam | The metabolism of Alprazolam can be decreased when combined with Dovitinib. |
| Warfarin | The serum concentration of Warfarin can be increased when it is combined with Dovitinib. |
| Acenocoumarol | The serum concentration of Acenocoumarol can be increased when it is combined with Dovitinib. |
| (R)-warfarin | The serum concentration of (R)-warfarin can be increased when it is combined with Dovitinib. |
| R,S-Warfarin alcohol | The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Dovitinib. |
| S,R-Warfarin alcohol | The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Dovitinib. |
| (S)-Warfarin | The serum concentration of (S)-Warfarin can be increased when it is combined with Dovitinib. |
| Midazolam | The serum concentration of Midazolam can be increased when it is combined with Dovitinib. |
| Tacrolimus | The serum concentration of Tacrolimus can be increased when it is combined with Dovitinib. |
| Atorvastatin | The metabolism of Atorvastatin can be decreased when combined with Dovitinib. |
| Eluxadoline | The serum concentration of Eluxadoline can be increased when it is combined with Dovitinib. |
| Folic acid | Dovitinib may decrease the excretion rate of Folic acid which could result in a higher serum level. |
| Allopurinol | Dovitinib may decrease the excretion rate of Allopurinol which could result in a higher serum level. |
| Raloxifene | Dovitinib may decrease the excretion rate of Raloxifene which could result in a higher serum level. |
| Celecoxib | Dovitinib may decrease the excretion rate of Celecoxib which could result in a higher serum level. |
| Oxaliplatin | Dovitinib may decrease the excretion rate of Oxaliplatin which could result in a higher serum level. |
| Testosterone | Dovitinib may decrease the excretion rate of Testosterone which could result in a higher serum level. |
| Clofarabine | Dovitinib may decrease the excretion rate of Clofarabine which could result in a higher serum level. |
| Nitrofurantoin | Dovitinib may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level. |
| Riluzole | Dovitinib may decrease the excretion rate of Riluzole which could result in a higher serum level. |
| Sulfasalazine | Dovitinib may decrease the excretion rate of Sulfasalazine which could result in a higher serum level. |
| Glyburide | Dovitinib may decrease the excretion rate of Glyburide which could result in a higher serum level. |
| Tegaserod | Dovitinib may decrease the excretion rate of Tegaserod which could result in a higher serum level. |
| Leflunomide | Dovitinib may decrease the excretion rate of Leflunomide which could result in a higher serum level. |
| Rosuvastatin | Dovitinib may decrease the excretion rate of Rosuvastatin which could result in a higher serum level. |
| Alvocidib | Dovitinib may decrease the excretion rate of Alvocidib which could result in a higher serum level. |
| Teriflunomide | Dovitinib may decrease the excretion rate of Teriflunomide which could result in a higher serum level. |
| Riociguat | Dovitinib may decrease the excretion rate of Riociguat which could result in a higher serum level. |
| Fimasartan | Dovitinib may decrease the excretion rate of Fimasartan which could result in a higher serum level. |
| Delafloxacin | Dovitinib may decrease the excretion rate of Delafloxacin which could result in a higher serum level. |
| Glasdegib | Dovitinib may decrease the excretion rate of Glasdegib which could result in a higher serum level. |
| Testosterone cypionate | Dovitinib may decrease the excretion rate of Testosterone cypionate which could result in a higher serum level. |
| Testosterone enanthate | Dovitinib may decrease the excretion rate of Testosterone enanthate which could result in a higher serum level. |
| Darolutamide | Dovitinib may decrease the excretion rate of Darolutamide which could result in a higher serum level. |
| Tazemetostat | Dovitinib may decrease the excretion rate of Tazemetostat which could result in a higher serum level. |
| Conjugated estrogens | Dovitinib may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level. |
| Gefitinib | Dovitinib may decrease the excretion rate of Gefitinib which could result in a higher serum level. |
| Cerivastatin | Dovitinib may decrease the excretion rate of Cerivastatin which could result in a higher serum level. |
| Prazosin | Dovitinib may decrease the excretion rate of Prazosin which could result in a higher serum level. |
| Zidovudine | Dovitinib may decrease the excretion rate of Zidovudine which could result in a higher serum level. |
| Ritonavir | Dovitinib may decrease the excretion rate of Ritonavir which could result in a higher serum level. |
| Ivermectin | Dovitinib may decrease the excretion rate of Ivermectin which could result in a higher serum level. |
| Sumatriptan | Dovitinib may decrease the excretion rate of Sumatriptan which could result in a higher serum level. |
| Mycophenolate mofetil | Dovitinib may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level. |
| Lamivudine | Dovitinib may decrease the excretion rate of Lamivudine which could result in a higher serum level. |
| Donepezil | Dovitinib may decrease the excretion rate of Donepezil which could result in a higher serum level. |
| Ezetimibe | Dovitinib may decrease the excretion rate of Ezetimibe which could result in a higher serum level. |
| Topotecan | Dovitinib may decrease the excretion rate of Topotecan which could result in a higher serum level. |
| Mitoxantrone | Dovitinib may decrease the excretion rate of Mitoxantrone which could result in a higher serum level. |
| Camptothecin | Dovitinib may decrease the excretion rate of Camptothecin which could result in a higher serum level. |
| Pitavastatin | The metabolism of Pitavastatin can be decreased when combined with Dovitinib. |
| Afatinib | Dovitinib may decrease the excretion rate of Afatinib which could result in a higher serum level. |
| Tenofovir alafenamide | The serum concentration of Tenofovir alafenamide can be increased when it is combined with Dovitinib. |
| Pravastatin | Dovitinib may decrease the excretion rate of Pravastatin which could result in a higher serum level. |
| Dactinomycin | Dovitinib may decrease the excretion rate of Dactinomycin which could result in a higher serum level. |
| Simeprevir | Dovitinib may decrease the excretion rate of Simeprevir which could result in a higher serum level. |
| Apixaban | Dovitinib may decrease the excretion rate of Apixaban which could result in a higher serum level. |
| Dolutegravir | Dovitinib may decrease the excretion rate of Dolutegravir which could result in a higher serum level. |
| Sofosbuvir | Dovitinib may decrease the excretion rate of Sofosbuvir which could result in a higher serum level. |
| Lenvatinib | Dovitinib may decrease the excretion rate of Lenvatinib which could result in a higher serum level. |
| Ombitasvir | Dovitinib may decrease the excretion rate of Ombitasvir which could result in a higher serum level. |
| Velpatasvir | Dovitinib may decrease the excretion rate of Velpatasvir which could result in a higher serum level. |
| Talazoparib | The serum concentration of Talazoparib can be increased when it is combined with Dovitinib. |
| Duvelisib | Dovitinib may decrease the excretion rate of Duvelisib which could result in a higher serum level. |
| Voxilaprevir | Dovitinib may decrease the excretion rate of Voxilaprevir which could result in a higher serum level. |
| Rucaparib | Dovitinib may decrease the excretion rate of Rucaparib which could result in a higher serum level. |
| Lusutrombopag | Dovitinib may decrease the excretion rate of Lusutrombopag which could result in a higher serum level. |
| Pibrentasvir | Dovitinib may decrease the excretion rate of Pibrentasvir which could result in a higher serum level. |
| Glecaprevir | Dovitinib may decrease the excretion rate of Glecaprevir which could result in a higher serum level. |
| Tucatinib | Dovitinib may decrease the excretion rate of Tucatinib which could result in a higher serum level. |
| Rivaroxaban | Dovitinib may decrease the excretion rate of Rivaroxaban which could result in a higher serum level. |
| Selumetinib | Dovitinib may decrease the excretion rate of Selumetinib which could result in a higher serum level. |
| Pralatrexate | Dovitinib may decrease the excretion rate of Pralatrexate which could result in a higher serum level. |
| Ripretinib | Dovitinib may decrease the excretion rate of Ripretinib which could result in a higher serum level. |
| Daunorubicin | Dovitinib may decrease the excretion rate of Daunorubicin which could result in a higher serum level. |
| Fostemsavir | Dovitinib may decrease the excretion rate of Fostemsavir which could result in a higher serum level. |
| Pralsetinib | Dovitinib may decrease the excretion rate of Pralsetinib which could result in a higher serum level. |
| Trilaciclib | Dovitinib may decrease the excretion rate of Trilaciclib which could result in a higher serum level. |
| Aripiprazole | The metabolism of Aripiprazole can be decreased when combined with Dovitinib. |
| Aripiprazole lauroxil | The metabolism of Aripiprazole lauroxil can be decreased when combined with Dovitinib. |
| Valsartan | The excretion of Valsartan can be decreased when combined with Dovitinib. |
| Torasemide | The excretion of Torasemide can be decreased when combined with Dovitinib. |
| Caspofungin | The excretion of Caspofungin can be decreased when combined with Dovitinib. |
| Bosentan | The excretion of Bosentan can be decreased when combined with Dovitinib. |
| Enalapril | The excretion of Enalapril can be decreased when combined with Dovitinib. |