Stamulumab

DB05915

biotech investigational

Deskripsi

MYO-029 is a human anti-GDF-8 monoclonal antibody, which is being developed to treat muscle-wasting diseases including muscular dystrophy and age-related sarcopenia.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

372 Data
Diethylstilbestrol Diethylstilbestrol may increase the thrombogenic activities of MYO-029.
Chlorotrianisene Chlorotrianisene may increase the thrombogenic activities of MYO-029.
Conjugated estrogens Conjugated estrogens may increase the thrombogenic activities of MYO-029.
Estrone Estrone may increase the thrombogenic activities of MYO-029.
Estradiol Estradiol may increase the thrombogenic activities of MYO-029.
Dienestrol Dienestrol may increase the thrombogenic activities of MYO-029.
Ethinylestradiol Ethinylestradiol may increase the thrombogenic activities of MYO-029.
Mestranol Mestranol may increase the thrombogenic activities of MYO-029.
Estriol Estriol may increase the thrombogenic activities of MYO-029.
Estrone sulfate Estrone sulfate may increase the thrombogenic activities of MYO-029.
Quinestrol Quinestrol may increase the thrombogenic activities of MYO-029.
Hexestrol Hexestrol may increase the thrombogenic activities of MYO-029.
Tibolone Tibolone may increase the thrombogenic activities of MYO-029.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may increase the thrombogenic activities of MYO-029.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may increase the thrombogenic activities of MYO-029.
Polyestradiol phosphate Polyestradiol phosphate may increase the thrombogenic activities of MYO-029.
Esterified estrogens Esterified estrogens may increase the thrombogenic activities of MYO-029.
Zeranol Zeranol may increase the thrombogenic activities of MYO-029.
Equol Equol may increase the thrombogenic activities of MYO-029.
Promestriene Promestriene may increase the thrombogenic activities of MYO-029.
Methallenestril Methallenestril may increase the thrombogenic activities of MYO-029.
Epimestrol Epimestrol may increase the thrombogenic activities of MYO-029.
Moxestrol Moxestrol may increase the thrombogenic activities of MYO-029.
Estradiol acetate Estradiol acetate may increase the thrombogenic activities of MYO-029.
Estradiol benzoate Estradiol benzoate may increase the thrombogenic activities of MYO-029.
Estradiol cypionate Estradiol cypionate may increase the thrombogenic activities of MYO-029.
Estradiol valerate Estradiol valerate may increase the thrombogenic activities of MYO-029.
Biochanin A Biochanin A may increase the thrombogenic activities of MYO-029.
Formononetin Formononetin may increase the thrombogenic activities of MYO-029.
Estetrol Estetrol may increase the thrombogenic activities of MYO-029.
Cetuximab The risk or severity of adverse effects can be increased when Cetuximab is combined with MYO-029.
Human immunoglobulin G The risk or severity of adverse effects can be increased when Human immunoglobulin G is combined with MYO-029.
Omalizumab The risk or severity of adverse effects can be increased when Omalizumab is combined with MYO-029.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with MYO-029.
Abciximab The risk or severity of adverse effects can be increased when Abciximab is combined with MYO-029.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with MYO-029.
Indium In-111 satumomab pendetide The risk or severity of adverse effects can be increased when Indium In-111 satumomab pendetide is combined with MYO-029.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with MYO-029.
Trastuzumab The risk or severity of adverse effects can be increased when Trastuzumab is combined with MYO-029.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with MYO-029.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with MYO-029.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with MYO-029.
Digoxin Immune Fab (Ovine) The risk or severity of adverse effects can be increased when Digoxin Immune Fab (Ovine) is combined with MYO-029.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with MYO-029.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with MYO-029.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with MYO-029.
Capromab pendetide The risk or severity of adverse effects can be increased when Capromab pendetide is combined with MYO-029.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with MYO-029.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with MYO-029.
Natalizumab The risk or severity of adverse effects can be increased when Natalizumab is combined with MYO-029.
Palivizumab The risk or severity of adverse effects can be increased when Palivizumab is combined with MYO-029.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with MYO-029.
Bevacizumab The risk or severity of adverse effects can be increased when Bevacizumab is combined with MYO-029.
Technetium Tc-99m arcitumomab The risk or severity of adverse effects can be increased when Technetium Tc-99m arcitumomab is combined with MYO-029.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with MYO-029.
Panitumumab The risk or severity of adverse effects can be increased when Panitumumab is combined with MYO-029.
Ranibizumab The risk or severity of adverse effects can be increased when Ranibizumab is combined with MYO-029.
Galiximab The risk or severity of adverse effects can be increased when Galiximab is combined with MYO-029.
Pexelizumab The risk or severity of adverse effects can be increased when Pexelizumab is combined with MYO-029.
Afelimomab The risk or severity of adverse effects can be increased when Afelimomab is combined with MYO-029.
Epratuzumab The risk or severity of adverse effects can be increased when Epratuzumab is combined with MYO-029.
Bectumomab The risk or severity of adverse effects can be increased when Bectumomab is combined with MYO-029.
Oregovomab The risk or severity of adverse effects can be increased when Oregovomab is combined with MYO-029.
IGN311 The risk or severity of adverse effects can be increased when IGN311 is combined with MYO-029.
Adecatumumab The risk or severity of adverse effects can be increased when Adecatumumab is combined with MYO-029.
Labetuzumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with MYO-029.
Matuzumab The risk or severity of adverse effects can be increased when Matuzumab is combined with MYO-029.
Fontolizumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with MYO-029.
Bavituximab The risk or severity of adverse effects can be increased when Bavituximab is combined with MYO-029.
CR002 The risk or severity of adverse effects can be increased when CR002 is combined with MYO-029.
Rozrolimupab The risk or severity of adverse effects can be increased when Rozrolimupab is combined with MYO-029.
Girentuximab The risk or severity of adverse effects can be increased when Girentuximab is combined with MYO-029.
Obiltoxaximab The risk or severity of adverse effects can be increased when Obiltoxaximab is combined with MYO-029.
XTL-001 The risk or severity of adverse effects can be increased when XTL-001 is combined with MYO-029.
NAV 1800 The risk or severity of adverse effects can be increased when NAV 1800 is combined with MYO-029.
Briakinumab The risk or severity of adverse effects can be increased when Briakinumab is combined with MYO-029.
Otelixizumab The risk or severity of adverse effects can be increased when Otelixizumab is combined with MYO-029.
AMG 108 The risk or severity of adverse effects can be increased when AMG 108 is combined with MYO-029.
Iratumumab The risk or severity of adverse effects can be increased when Iratumumab is combined with MYO-029.
Enokizumab The risk or severity of adverse effects can be increased when Enokizumab is combined with MYO-029.
Ramucirumab The risk or severity of adverse effects can be increased when Ramucirumab is combined with MYO-029.
Farletuzumab The risk or severity of adverse effects can be increased when Farletuzumab is combined with MYO-029.
Veltuzumab The risk or severity of adverse effects can be increased when Veltuzumab is combined with MYO-029.
Ustekinumab The risk or severity of adverse effects can be increased when Ustekinumab is combined with MYO-029.
Trastuzumab emtansine The risk or severity of adverse effects can be increased when Trastuzumab emtansine is combined with MYO-029.
PRO-542 The risk or severity of adverse effects can be increased when PRO-542 is combined with MYO-029.
TNX-901 The risk or severity of adverse effects can be increased when TNX-901 is combined with MYO-029.
Inotuzumab ozogamicin The risk or severity of adverse effects can be increased when Inotuzumab ozogamicin is combined with MYO-029.
RI 624 The risk or severity of adverse effects can be increased when RI 624 is combined with MYO-029.
CT-011 The risk or severity of adverse effects can be increased when MYO-029 is combined with CT-011.
Leronlimab The risk or severity of adverse effects can be increased when MYO-029 is combined with Leronlimab.
Glembatumumab vedotin The risk or severity of adverse effects can be increased when MYO-029 is combined with Glembatumumab vedotin.
Olaratumab The risk or severity of adverse effects can be increased when MYO-029 is combined with Olaratumab.
IPH 2101 The risk or severity of adverse effects can be increased when MYO-029 is combined with IPH 2101.
TB-402 The risk or severity of adverse effects can be increased when MYO-029 is combined with TB-402.
Caplacizumab The risk or severity of adverse effects can be increased when MYO-029 is combined with Caplacizumab.
IMC-1C11 The risk or severity of adverse effects can be increased when MYO-029 is combined with IMC-1C11.
Eldelumab The risk or severity of adverse effects can be increased when MYO-029 is combined with Eldelumab.
Lumiliximab The risk or severity of adverse effects can be increased when MYO-029 is combined with Lumiliximab.
Canakinumab The risk or severity of adverse effects can be increased when MYO-029 is combined with Canakinumab.

Target Protein

Growth/differentiation factor 8 MSTN

Referensi & Sumber

Artikel (PubMed)
  • PMID: 18335515
    Wagner KR, Fleckenstein JL, Amato AA, Barohn RJ, Bushby K, Escolar DM, Flanigan KM, Pestronk A, Tawil R, Wolfe GI, Eagle M, Florence JM, King WM, Pandya S, Straub V, Juneau P, Meyers K, Csimma C, Araujo T, Allen R, Parsons SA, Wozney JM, Lavallie ER, Mendell JR: A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy. Ann Neurol. 2008 May;63(5):561-71. doi: 10.1002/ana.21338.
  • PMID: 17432227
    Sunada Y: Therapeutic strategies for muscular dystrophy by myostatin inhibition. Rinsho Shinkeigaku. 2006 Nov;46(11):942-4.
  • PMID: 12459784
    Bogdanovich S, Krag TO, Barton ER, Morris LD, Whittemore LA, Ahima RS, Khurana TS: Functional improvement of dystrophic muscle by myostatin blockade. Nature. 2002 Nov 28;420(6914):418-21.

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