KOS-1584 is a second-generation epothilone. Epothilones are anticancer agents with a taxane-like mechanism of action that have demonstrated activity in taxane-resistant tumors. KOS-1584 is a second-generation compound with increased potency, favorable tissue distribution, and ease of formulation.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Eliglustat | The metabolism of Eliglustat can be decreased when combined with KOS-1584. |
| Ibrutinib | The metabolism of Ibrutinib can be decreased when combined with KOS-1584. |
| Alfentanil | The serum concentration of Alfentanil can be increased when it is combined with KOS-1584. |
| Buspirone | The metabolism of Buspirone can be decreased when combined with KOS-1584. |
| Carbamazepine | The metabolism of Carbamazepine can be decreased when combined with KOS-1584. |
| Cisapride | The serum concentration of Cisapride can be increased when it is combined with KOS-1584. |
| Disopyramide | KOS-1584 may increase the QTc-prolonging activities of Disopyramide. |
| Estazolam | The serum concentration of Estazolam can be increased when it is combined with KOS-1584. |
| Quinine | The serum concentration of Quinine can be increased when it is combined with KOS-1584. |
| Quinidine | The serum concentration of Quinidine can be increased when it is combined with KOS-1584. |
| Repaglinide | The serum concentration of Repaglinide can be increased when it is combined with KOS-1584. |
| Sirolimus | The metabolism of Sirolimus can be decreased when combined with KOS-1584. |
| Temsirolimus | The metabolism of Temsirolimus can be decreased when combined with KOS-1584. |
| Terfenadine | The serum concentration of Terfenadine can be increased when it is combined with KOS-1584. |
| Triazolam | The serum concentration of Triazolam can be increased when it is combined with KOS-1584. |
| Cilostazol | The metabolism of Cilostazol can be decreased when combined with KOS-1584. |
| Colchicine | The metabolism of Colchicine can be decreased when combined with KOS-1584. |
| Iloperidone | The metabolism of Iloperidone can be decreased when combined with KOS-1584. |
| Retapamulin | The metabolism of Retapamulin can be decreased when combined with KOS-1584. |
| Tofacitinib | The metabolism of Tofacitinib can be decreased when combined with KOS-1584. |
| Vardenafil | The metabolism of Vardenafil can be decreased when combined with KOS-1584. |
| Eszopiclone | The metabolism of Eszopiclone can be decreased when combined with KOS-1584. |
| Zopiclone | The metabolism of Zopiclone can be decreased when combined with KOS-1584. |
| Lovastatin | The metabolism of Lovastatin can be decreased when combined with KOS-1584. |
| Alfuzosin | The metabolism of Alfuzosin can be decreased when combined with KOS-1584. |
| Alprazolam | The serum concentration of Alprazolam can be increased when it is combined with KOS-1584. |
| Warfarin | The serum concentration of Warfarin can be increased when it is combined with KOS-1584. |
| Acenocoumarol | The serum concentration of Acenocoumarol can be increased when it is combined with KOS-1584. |
| (R)-warfarin | The serum concentration of (R)-warfarin can be increased when it is combined with KOS-1584. |
| R,S-Warfarin alcohol | The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with KOS-1584. |
| S,R-Warfarin alcohol | The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with KOS-1584. |
| (S)-Warfarin | The serum concentration of (S)-Warfarin can be increased when it is combined with KOS-1584. |
| Midazolam | The serum concentration of Midazolam can be increased when it is combined with KOS-1584. |
| Tacrolimus | The serum concentration of Tacrolimus can be increased when it is combined with KOS-1584. |
| Telaprevir | The serum concentration of Telaprevir can be increased when it is combined with KOS-1584. |
| Picosulfuric acid | The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with KOS-1584. |
| Vintafolide | The serum concentration of Vintafolide can be increased when it is combined with KOS-1584. |
| Vincamine | The serum concentration of Vincamine can be increased when it is combined with KOS-1584. |
| Acetyldigitoxin | The serum concentration of Acetyldigitoxin can be increased when it is combined with KOS-1584. |
| Deslanoside | The serum concentration of Deslanoside can be increased when it is combined with KOS-1584. |
| Ouabain | The serum concentration of Ouabain can be increased when it is combined with KOS-1584. |
| Oleandrin | The serum concentration of Oleandrin can be increased when it is combined with KOS-1584. |
| Cymarin | The serum concentration of Cymarin can be increased when it is combined with KOS-1584. |
| Proscillaridin | The serum concentration of Proscillaridin can be increased when it is combined with KOS-1584. |
| Metildigoxin | The serum concentration of Metildigoxin can be increased when it is combined with KOS-1584. |
| Lanatoside C | The serum concentration of Lanatoside C can be increased when it is combined with KOS-1584. |
| Gitoformate | The serum concentration of Gitoformate can be increased when it is combined with KOS-1584. |
| Acetyldigoxin | The serum concentration of Acetyldigoxin can be increased when it is combined with KOS-1584. |
| Peruvoside | The serum concentration of Peruvoside can be increased when it is combined with KOS-1584. |
| Cyclosporine | The metabolism of Cyclosporine can be decreased when combined with KOS-1584. |
| Dicoumarol | The serum concentration of Dicoumarol can be increased when it is combined with KOS-1584. |
| Phenindione | The serum concentration of Phenindione can be increased when it is combined with KOS-1584. |
| Coumarin | The serum concentration of Coumarin can be increased when it is combined with KOS-1584. |
| Tioclomarol | The serum concentration of Tioclomarol can be increased when it is combined with KOS-1584. |
| Ethyl biscoumacetate | The serum concentration of Ethyl biscoumacetate can be increased when it is combined with KOS-1584. |
| Diphenadione | The serum concentration of Diphenadione can be increased when it is combined with KOS-1584. |
| 4-hydroxycoumarin | The serum concentration of 4-hydroxycoumarin can be increased when it is combined with KOS-1584. |
| Fluindione | The serum concentration of Fluindione can be increased when it is combined with KOS-1584. |
| Clorindione | The serum concentration of Clorindione can be increased when it is combined with KOS-1584. |
| Oxtriphylline | The metabolism of Oxtriphylline can be decreased when combined with KOS-1584. |
| Doxofylline | The metabolism of Doxofylline can be decreased when combined with KOS-1584. |
| Bamifylline | The metabolism of Bamifylline can be decreased when combined with KOS-1584. |
| Acefylline | The metabolism of Acefylline can be decreased when combined with KOS-1584. |
| Bufylline | The metabolism of Bufylline can be decreased when combined with KOS-1584. |
| Fenethylline | The metabolism of Fenethylline can be decreased when combined with KOS-1584. |
| Proxyphylline | The metabolism of Proxyphylline can be decreased when combined with KOS-1584. |
| Bromotheophylline | The metabolism of Bromotheophylline can be decreased when combined with KOS-1584. |
| Pentoxifylline | The metabolism of Pentoxifylline can be decreased when combined with KOS-1584. |
| 8-azaguanine | The metabolism of 8-azaguanine can be decreased when combined with KOS-1584. |
| 7,9-Dimethylguanine | The metabolism of 7,9-Dimethylguanine can be decreased when combined with KOS-1584. |
| Xanthine | The metabolism of Xanthine can be decreased when combined with KOS-1584. |
| 7-Deazaguanine | The metabolism of 7-Deazaguanine can be decreased when combined with KOS-1584. |
| Guanine | The metabolism of Guanine can be decreased when combined with KOS-1584. |
| 9-Methylguanine | The metabolism of 9-Methylguanine can be decreased when combined with KOS-1584. |
| Peldesine | The metabolism of Peldesine can be decreased when combined with KOS-1584. |
| Hypoxanthine | The metabolism of Hypoxanthine can be decreased when combined with KOS-1584. |
| 9-Deazaguanine | The metabolism of 9-Deazaguanine can be decreased when combined with KOS-1584. |
| Valomaciclovir | The metabolism of Valomaciclovir can be decreased when combined with KOS-1584. |
| 3-isobutyl-1-methyl-7H-xanthine | The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with KOS-1584. |
| Uric acid | The metabolism of Uric acid can be decreased when combined with KOS-1584. |
| 6-O-benzylguanine | The metabolism of 6-O-benzylguanine can be decreased when combined with KOS-1584. |
| Lisofylline | The metabolism of Lisofylline can be decreased when combined with KOS-1584. |
| Lobucavir | The metabolism of Lobucavir can be decreased when combined with KOS-1584. |
| Cafedrine | The metabolism of Cafedrine can be decreased when combined with KOS-1584. |
| Theodrenaline | The metabolism of Theodrenaline can be decreased when combined with KOS-1584. |
| Etamiphylline | The metabolism of Etamiphylline can be decreased when combined with KOS-1584. |
| Pentifylline | The metabolism of Pentifylline can be decreased when combined with KOS-1584. |
| Furafylline | The metabolism of Furafylline can be decreased when combined with KOS-1584. |
| Theobromine | The metabolism of Theobromine can be decreased when combined with KOS-1584. |
| Propentofylline | The metabolism of Propentofylline can be decreased when combined with KOS-1584. |
| Caffeine | The metabolism of Caffeine can be decreased when combined with KOS-1584. |
| 8-chlorotheophylline | The metabolism of 8-chlorotheophylline can be decreased when combined with KOS-1584. |
| Mercaptopurine | The metabolism of Mercaptopurine can be decreased when combined with KOS-1584. |
| PCS-499 | The metabolism of PCS-499 can be decreased when combined with KOS-1584. |
| Methylergometrine | The serum concentration of Methylergometrine can be increased when it is combined with KOS-1584. |
| Lisuride | The serum concentration of Lisuride can be increased when it is combined with KOS-1584. |
| Nicergoline | The serum concentration of Nicergoline can be increased when it is combined with KOS-1584. |
| Ergoloid mesylate | The serum concentration of Ergoloid mesylate can be increased when it is combined with KOS-1584. |
| Pergolide | The serum concentration of Pergolide can be increased when it is combined with KOS-1584. |
| Ergometrine | The serum concentration of Ergometrine can be increased when it is combined with KOS-1584. |