High doses of 2000 mg/kg/day in the mouse and rat and ?600 mg/kg/day in the dog were not well tolerated in animal studies. Seletracetam does not possess potential teratogenic, reproductive or embryonic toxicities. Most adverse effects are CNS-related effects, including somnolence, dizziness, feeling drunk, euphoria and nausea which all usually tend to be resolved within 24 hours.
Seletracetam is a pyrrolidone derivative and with a structural similarity to newer generation antiepileptic drug levetiracetam. It binds to the same target as levetiracetam but with higher affinity and has shown potent seizure suppression in models of acquired and genetic epilepsy with high CNS tolerability. It is predicted to have low drug-drug interactions and inhibition or induction of any major human metabolizing enzymes. Seletracetam was in Phase II clinical trials under the supervision of the U.S. Food and Drug Administration (FDA) investigated as treatment of epilepsy and partial epilepsy however its development had been put on hold in July 2007. As of 2010, its production was further halted due to the investigation of a newer antiepileptic agent, brivaracetam.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Ceritinib | Seletracetam may increase the bradycardic activities of Ceritinib. |
| Ivabradine | Seletracetam may increase the bradycardic activities of Ivabradine. |
| Ruxolitinib | Ruxolitinib may increase the bradycardic activities of Seletracetam. |
| Cimetidine | The serum concentration of Seletracetam can be increased when it is combined with Cimetidine. |
| Clopidogrel | The therapeutic efficacy of Clopidogrel can be decreased when used in combination with Seletracetam. |
| Efavirenz | The serum concentration of Seletracetam can be decreased when it is combined with Efavirenz. |
| Melatonin | The therapeutic efficacy of Seletracetam can be decreased when used in combination with Melatonin. |
| Nafcillin | The therapeutic efficacy of Seletracetam can be decreased when used in combination with Nafcillin. |
| Nitroprusside | Seletracetam may increase the hypotensive activities of Nitroprusside. |
| Dantrolene | The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Seletracetam. |
| Lithium citrate | The risk or severity of adverse effects can be increased when Seletracetam is combined with Lithium citrate. |
| Lithium carbonate | The risk or severity of adverse effects can be increased when Seletracetam is combined with Lithium carbonate. |
| Lithium hydroxide | The risk or severity of adverse effects can be increased when Seletracetam is combined with Lithium hydroxide. |
| Boceprevir | The serum concentration of Seletracetam can be increased when it is combined with Boceprevir. |
| Ibutilide | Ibutilide may increase the arrhythmogenic activities of Seletracetam. |
| Hyoscyamine | Hyoscyamine may increase the arrhythmogenic activities of Seletracetam. |
| Atropine | Atropine may increase the arrhythmogenic activities of Seletracetam. |
| Adenosine | Adenosine may increase the arrhythmogenic activities of Seletracetam. |
| Moricizine | Moricizine may increase the arrhythmogenic activities of Seletracetam. |
| Levosimendan | Levosimendan may increase the arrhythmogenic activities of Seletracetam. |
| Procainamide | Procainamide may increase the arrhythmogenic activities of Seletracetam. |
| Tocainide | Tocainide may increase the arrhythmogenic activities of Seletracetam. |
| Flecainide | Flecainide may increase the arrhythmogenic activities of Seletracetam. |
| Encainide | Encainide may increase the arrhythmogenic activities of Seletracetam. |
| Ajmaline | Ajmaline may increase the arrhythmogenic activities of Seletracetam. |
| Aprindine | Aprindine may increase the arrhythmogenic activities of Seletracetam. |
| Azimilide | Azimilide may increase the arrhythmogenic activities of Seletracetam. |
| Carteolol | Seletracetam may increase the arrhythmogenic activities of Carteolol. |
| Metipranolol | Seletracetam may increase the arrhythmogenic activities of Metipranolol. |
| Tedisamil | Seletracetam may increase the arrhythmogenic activities of Tedisamil. |
| Vernakalant | Seletracetam may increase the arrhythmogenic activities of Vernakalant. |
| Cariporide | Seletracetam may increase the arrhythmogenic activities of Cariporide. |
| Xylometazoline | Seletracetam may increase the arrhythmogenic activities of Xylometazoline. |
| Sparteine | Seletracetam may increase the arrhythmogenic activities of Sparteine. |
| Fasudil | Seletracetam may increase the arrhythmogenic activities of Fasudil. |
| Melperone | Seletracetam may increase the arrhythmogenic activities of Melperone. |
| Tropisetron | Seletracetam may increase the arrhythmogenic activities of Tropisetron. |
| Simendan | Seletracetam may increase the arrhythmogenic activities of Simendan. |
| Spiradoline | Seletracetam may increase the arrhythmogenic activities of Spiradoline. |
| Pilsicainide | Seletracetam may increase the arrhythmogenic activities of Pilsicainide. |
| Cicletanine | Seletracetam may increase the arrhythmogenic activities of Cicletanine. |
| Cibenzoline | Seletracetam may increase the arrhythmogenic activities of Cibenzoline. |
| Nizofenone | Seletracetam may increase the arrhythmogenic activities of Nizofenone. |
| Prajmaline | Seletracetam may increase the arrhythmogenic activities of Prajmaline. |
| Tiracizine | Seletracetam may increase the arrhythmogenic activities of Tiracizine. |
| Ethacizine | Seletracetam may increase the arrhythmogenic activities of Ethacizine. |
| Lorajmine | Seletracetam may increase the arrhythmogenic activities of Lorajmine. |
| Bunaftine | Seletracetam may increase the arrhythmogenic activities of Bunaftine. |
| Lorcainide | Seletracetam may increase the arrhythmogenic activities of Lorcainide. |
| Hydroquinine | Seletracetam may increase the arrhythmogenic activities of Hydroquinine. |
| Bioallethrin | Seletracetam may increase the arrhythmogenic activities of Bioallethrin. |
| Fosfructose | Seletracetam may increase the arrhythmogenic activities of Fosfructose. |
| Hydroquinidine | Seletracetam may increase the arrhythmogenic activities of Hydroquinidine. |
| SOR-C13 | Seletracetam may increase the arrhythmogenic activities of SOR-C13. |
| Digoxin | Digoxin may increase the arrhythmogenic activities of Seletracetam. |
| Acetyldigitoxin | Acetyldigitoxin may increase the arrhythmogenic activities of Seletracetam. |
| Deslanoside | Deslanoside may increase the arrhythmogenic activities of Seletracetam. |
| Cymarin | Seletracetam may increase the arrhythmogenic activities of Cymarin. |
| Metildigoxin | Seletracetam may increase the arrhythmogenic activities of Metildigoxin. |
| Acetyldigoxin | Seletracetam may increase the arrhythmogenic activities of Acetyldigoxin. |
| Niguldipine | Seletracetam may increase the arrhythmogenic activities of Niguldipine. |
| Bretylium | Bretylium may increase the arrhythmogenic activities of Seletracetam. |
| Isradipine | Isradipine may increase the arrhythmogenic activities of Seletracetam. |
| Diltiazem | Diltiazem may increase the arrhythmogenic activities of Seletracetam. |
| Trimethadione | Trimethadione may increase the arrhythmogenic activities of Seletracetam. |
| Amlodipine | Amlodipine may increase the arrhythmogenic activities of Seletracetam. |
| Nimodipine | Nimodipine may increase the arrhythmogenic activities of Seletracetam. |
| Lercanidipine | Lercanidipine may increase the arrhythmogenic activities of Seletracetam. |
| Lamotrigine | Lamotrigine may increase the arrhythmogenic activities of Seletracetam. |
| Cinnarizine | Cinnarizine may increase the arrhythmogenic activities of Seletracetam. |
| Nicardipine | Nicardipine may increase the arrhythmogenic activities of Seletracetam. |
| Verapamil | Verapamil may increase the arrhythmogenic activities of Seletracetam. |
| Losartan | Losartan may increase the arrhythmogenic activities of Seletracetam. |
| Levomenthol | Levomenthol may increase the arrhythmogenic activities of Seletracetam. |
| Zonisamide | Zonisamide may increase the arrhythmogenic activities of Seletracetam. |
| Nitrendipine | Nitrendipine may increase the arrhythmogenic activities of Seletracetam. |
| Perhexiline | Perhexiline may increase the arrhythmogenic activities of Seletracetam. |
| Bepridil | Bepridil may increase the arrhythmogenic activities of Seletracetam. |
| Nimesulide | Nimesulide may increase the arrhythmogenic activities of Seletracetam. |
| Prenylamine | Prenylamine may increase the arrhythmogenic activities of Seletracetam. |
| Cyclandelate | Cyclandelate may increase the arrhythmogenic activities of Seletracetam. |
| Flunarizine | Flunarizine may increase the arrhythmogenic activities of Seletracetam. |
| Fluspirilene | Fluspirilene may increase the arrhythmogenic activities of Seletracetam. |
| Clevidipine | Clevidipine may increase the arrhythmogenic activities of Seletracetam. |
| Methsuximide | Methsuximide may increase the arrhythmogenic activities of Seletracetam. |
| Nylidrin | Seletracetam may increase the arrhythmogenic activities of Nylidrin. |
| Ziconotide | Seletracetam may increase the arrhythmogenic activities of Ziconotide. |
| Dotarizine | Seletracetam may increase the arrhythmogenic activities of Dotarizine. |
| Nilvadipine | Seletracetam may increase the arrhythmogenic activities of Nilvadipine. |
| Tranilast | Seletracetam may increase the arrhythmogenic activities of Tranilast. |
| Agmatine | Seletracetam may increase the arrhythmogenic activities of Agmatine. |
| Fendiline | Seletracetam may increase the arrhythmogenic activities of Fendiline. |
| Eperisone | Seletracetam may increase the arrhythmogenic activities of Eperisone. |
| Trimebutine | Seletracetam may increase the arrhythmogenic activities of Trimebutine. |
| Pinaverium | Seletracetam may increase the arrhythmogenic activities of Pinaverium. |
| Nicorandil | Seletracetam may increase the arrhythmogenic activities of Nicorandil. |
| Barnidipine | Seletracetam may increase the arrhythmogenic activities of Barnidipine. |
| Aranidipine | Seletracetam may increase the arrhythmogenic activities of Aranidipine. |
| Azelnidipine | Seletracetam may increase the arrhythmogenic activities of Azelnidipine. |
| Benidipine | Seletracetam may increase the arrhythmogenic activities of Benidipine. |