Trestolone

DB05830

small molecule investigational

Deskripsi

Trestolone (7?-methyl-19-nortestosterone) is a synthetic androgen developed by the Population Council as a potential candidate drug for use in hormonal male contraceptive methods. In males, regular administration of sufficient quantities of trestolone induces a state of temporary infertility.

Struktur Molekul 2D

Berat 288.431
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

402 Data
Aprepitant The serum concentration of Trestolone can be decreased when it is combined with Aprepitant.
Exenatide Exenatide can cause a decrease in the absorption of Trestolone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Thalidomide Trestolone may increase the thrombogenic activities of Thalidomide.
Tranexamic acid Trestolone may increase the thrombogenic activities of Tranexamic acid.
Clobazam The serum concentration of Trestolone can be decreased when it is combined with Clobazam.
Griseofulvin The metabolism of Trestolone can be increased when combined with Griseofulvin.
Clobetasol propionate The serum concentration of Clobetasol propionate can be increased when it is combined with Trestolone.
Fluocinonide The serum concentration of Fluocinonide can be increased when it is combined with Trestolone.
Hydrocortisone butyrate The serum concentration of Hydrocortisone butyrate can be increased when it is combined with Trestolone.
Desoximetasone The serum concentration of Desoximetasone can be increased when it is combined with Trestolone.
Mometasone The serum concentration of Mometasone can be increased when it is combined with Trestolone.
Fluocortolone The serum concentration of Fluocortolone can be increased when it is combined with Trestolone.
Prednisolone acetate The serum concentration of Prednisolone acetate can be increased when it is combined with Trestolone.
Fluorometholone The serum concentration of Fluorometholone can be increased when it is combined with Trestolone.
Difluocortolone The serum concentration of Difluocortolone can be increased when it is combined with Trestolone.
Flumethasone The serum concentration of Flumethasone can be increased when it is combined with Trestolone.
Methylprednisolone aceponate The serum concentration of Methylprednisolone aceponate can be increased when it is combined with Trestolone.
Bosentan The serum concentration of Trestolone can be decreased when it is combined with Bosentan.
Carbamazepine The serum concentration of Trestolone can be decreased when it is combined with Carbamazepine.
Piperacillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Piperacillin.
Ampicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Ampicillin.
Phenoxymethylpenicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Phenoxymethylpenicillin.
Carbenicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Carbenicillin.
Oxacillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Oxacillin.
Hetacillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Hetacillin.
Benzylpenicilloyl polylysine The therapeutic efficacy of Trestolone can be decreased when used in combination with Benzylpenicilloyl polylysine.
Mezlocillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Mezlocillin.
Cyclacillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Cyclacillin.
Benzylpenicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Benzylpenicillin.
Amoxicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Amoxicillin.
Azlocillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Azlocillin.
Cloxacillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Cloxacillin.
Amdinocillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Amdinocillin.
Bacampicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Bacampicillin.
Meticillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Meticillin.
Pivampicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Pivampicillin.
Pivmecillinam The therapeutic efficacy of Trestolone can be decreased when used in combination with Pivmecillinam.
Ticarcillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Ticarcillin.
Azidocillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Azidocillin.
Carindacillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Carindacillin.
Procaine benzylpenicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Procaine benzylpenicillin.
Sultamicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Sultamicillin.
Temocillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Temocillin.
Epicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Epicillin.
Pheneticillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Pheneticillin.
Carfecillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Carfecillin.
Propicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Propicillin.
Clometocillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Clometocillin.
Sulbenicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Sulbenicillin.
Penamecillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Penamecillin.
Talampicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Talampicillin.
Aspoxicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Aspoxicillin.
Metampicillin The therapeutic efficacy of Trestolone can be decreased when used in combination with Metampicillin.
Lepirudin The therapeutic efficacy of Lepirudin can be decreased when used in combination with Trestolone.
Bivalirudin The therapeutic efficacy of Bivalirudin can be decreased when used in combination with Trestolone.
Alteplase The therapeutic efficacy of Alteplase can be decreased when used in combination with Trestolone.
Urokinase The therapeutic efficacy of Urokinase can be decreased when used in combination with Trestolone.
Reteplase The therapeutic efficacy of Reteplase can be decreased when used in combination with Trestolone.
Anistreplase The therapeutic efficacy of Anistreplase can be decreased when used in combination with Trestolone.
Tenecteplase The therapeutic efficacy of Tenecteplase can be decreased when used in combination with Trestolone.
Abciximab The therapeutic efficacy of Abciximab can be decreased when used in combination with Trestolone.
Drotrecogin alfa The therapeutic efficacy of Drotrecogin alfa can be decreased when used in combination with Trestolone.
Streptokinase The therapeutic efficacy of Streptokinase can be decreased when used in combination with Trestolone.
Dicoumarol The therapeutic efficacy of Dicoumarol can be decreased when used in combination with Trestolone.
Argatroban The therapeutic efficacy of Argatroban can be decreased when used in combination with Trestolone.
Ardeparin The therapeutic efficacy of Ardeparin can be decreased when used in combination with Trestolone.
Phenindione The therapeutic efficacy of Phenindione can be decreased when used in combination with Trestolone.
Fondaparinux The therapeutic efficacy of Fondaparinux can be decreased when used in combination with Trestolone.
Warfarin The therapeutic efficacy of Warfarin can be decreased when used in combination with Trestolone.
Pentosan polysulfate The therapeutic efficacy of Pentosan polysulfate can be decreased when used in combination with Trestolone.
Phenprocoumon The therapeutic efficacy of Phenprocoumon can be decreased when used in combination with Trestolone.
Dipyridamole The therapeutic efficacy of Dipyridamole can be decreased when used in combination with Trestolone.
Heparin The therapeutic efficacy of Heparin can be decreased when used in combination with Trestolone.
Enoxaparin The therapeutic efficacy of Enoxaparin can be decreased when used in combination with Trestolone.
Epoprostenol The therapeutic efficacy of Epoprostenol can be decreased when used in combination with Trestolone.
Acenocoumarol The therapeutic efficacy of Acenocoumarol can be decreased when used in combination with Trestolone.
4-hydroxycoumarin The therapeutic efficacy of 4-hydroxycoumarin can be decreased when used in combination with Trestolone.
Coumarin The therapeutic efficacy of Coumarin can be decreased when used in combination with Trestolone.
Ximelagatran The therapeutic efficacy of Ximelagatran can be decreased when used in combination with Trestolone.
Desmoteplase The therapeutic efficacy of Desmoteplase can be decreased when used in combination with Trestolone.
Defibrotide The therapeutic efficacy of Defibrotide can be decreased when used in combination with Trestolone.
Ancrod The therapeutic efficacy of Ancrod can be decreased when used in combination with Trestolone.
Beraprost The therapeutic efficacy of Beraprost can be decreased when used in combination with Trestolone.
Prasugrel The therapeutic efficacy of Prasugrel can be decreased when used in combination with Trestolone.
Rivaroxaban The therapeutic efficacy of Rivaroxaban can be decreased when used in combination with Trestolone.
Sulodexide The therapeutic efficacy of Sulodexide can be decreased when used in combination with Trestolone.
Semuloparin The therapeutic efficacy of Semuloparin can be decreased when used in combination with Trestolone.
Idraparinux The therapeutic efficacy of Idraparinux can be decreased when used in combination with Trestolone.
Cangrelor The therapeutic efficacy of Cangrelor can be decreased when used in combination with Trestolone.
Astaxanthin The therapeutic efficacy of Astaxanthin can be decreased when used in combination with Trestolone.
Apixaban The therapeutic efficacy of Apixaban can be decreased when used in combination with Trestolone.
Otamixaban The therapeutic efficacy of Otamixaban can be decreased when used in combination with Trestolone.
Amediplase The therapeutic efficacy of Amediplase can be decreased when used in combination with Trestolone.
Dabigatran etexilate The therapeutic efficacy of Dabigatran etexilate can be decreased when used in combination with Trestolone.
Danaparoid The therapeutic efficacy of Danaparoid can be decreased when used in combination with Trestolone.
Dalteparin The therapeutic efficacy of Dalteparin can be decreased when used in combination with Trestolone.
Tinzaparin The therapeutic efficacy of Tinzaparin can be decreased when used in combination with Trestolone.
(R)-warfarin The therapeutic efficacy of (R)-warfarin can be decreased when used in combination with Trestolone.
Ethyl biscoumacetate The therapeutic efficacy of Ethyl biscoumacetate can be decreased when used in combination with Trestolone.
Nadroparin The therapeutic efficacy of Nadroparin can be decreased when used in combination with Trestolone.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17460095
    Walton MJ, Kumar N, Baird DT, Ludlow H, Anderson RA: 7alpha-methyl-19-nortestosterone (MENT) vs testosterone in combination with etonogestrel implants for spermatogenic suppression in healthy men. J Androl. 2007 Sep-Oct;28(5):679-88. Epub 2007 Apr 25.
  • PMID: 12141943
    Ramachandra SG, Ramesh V, Krishnamurthy HN, Kumar N, Sundaram K, Hardy MP, Rao AJ: Effect of chronic administration of 7alpha-methyl-19-nortestosterone on serum testosterone, number of spermatozoa and fertility in adult male bonnet monkeys (Macaca radiata). Reproduction. 2002 Aug;124(2):301-9.

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