PRO-542

DB05793

biotech investigational

Deskripsi

PRO 542 belongs to a new class of drugs, viral-entry inhibitor, which is intended to prevent HIV from entering and infecting cells. PRO 542 (CD4-immunoglobulin G2) is a tetravalent CD4-immunoglobulin fusion protein that broadly neutralizes primary HIV-1 isolates.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

372 Data
Diethylstilbestrol Diethylstilbestrol may increase the thrombogenic activities of PRO-542.
Chlorotrianisene Chlorotrianisene may increase the thrombogenic activities of PRO-542.
Conjugated estrogens Conjugated estrogens may increase the thrombogenic activities of PRO-542.
Estrone Estrone may increase the thrombogenic activities of PRO-542.
Estradiol Estradiol may increase the thrombogenic activities of PRO-542.
Dienestrol Dienestrol may increase the thrombogenic activities of PRO-542.
Ethinylestradiol Ethinylestradiol may increase the thrombogenic activities of PRO-542.
Mestranol Mestranol may increase the thrombogenic activities of PRO-542.
Estriol Estriol may increase the thrombogenic activities of PRO-542.
Estrone sulfate Estrone sulfate may increase the thrombogenic activities of PRO-542.
Quinestrol Quinestrol may increase the thrombogenic activities of PRO-542.
Hexestrol Hexestrol may increase the thrombogenic activities of PRO-542.
Tibolone Tibolone may increase the thrombogenic activities of PRO-542.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may increase the thrombogenic activities of PRO-542.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may increase the thrombogenic activities of PRO-542.
Polyestradiol phosphate Polyestradiol phosphate may increase the thrombogenic activities of PRO-542.
Esterified estrogens Esterified estrogens may increase the thrombogenic activities of PRO-542.
Zeranol Zeranol may increase the thrombogenic activities of PRO-542.
Equol Equol may increase the thrombogenic activities of PRO-542.
Promestriene Promestriene may increase the thrombogenic activities of PRO-542.
Methallenestril Methallenestril may increase the thrombogenic activities of PRO-542.
Epimestrol Epimestrol may increase the thrombogenic activities of PRO-542.
Moxestrol Moxestrol may increase the thrombogenic activities of PRO-542.
Estradiol acetate Estradiol acetate may increase the thrombogenic activities of PRO-542.
Estradiol benzoate Estradiol benzoate may increase the thrombogenic activities of PRO-542.
Estradiol cypionate Estradiol cypionate may increase the thrombogenic activities of PRO-542.
Estradiol valerate Estradiol valerate may increase the thrombogenic activities of PRO-542.
Biochanin A Biochanin A may increase the thrombogenic activities of PRO-542.
Formononetin Formononetin may increase the thrombogenic activities of PRO-542.
Estetrol Estetrol may increase the thrombogenic activities of PRO-542.
Cetuximab The risk or severity of adverse effects can be increased when Cetuximab is combined with PRO-542.
Human immunoglobulin G The risk or severity of adverse effects can be increased when Human immunoglobulin G is combined with PRO-542.
Omalizumab The risk or severity of adverse effects can be increased when Omalizumab is combined with PRO-542.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with PRO-542.
Abciximab The risk or severity of adverse effects can be increased when Abciximab is combined with PRO-542.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with PRO-542.
Indium In-111 satumomab pendetide The risk or severity of adverse effects can be increased when Indium In-111 satumomab pendetide is combined with PRO-542.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with PRO-542.
Trastuzumab The risk or severity of adverse effects can be increased when Trastuzumab is combined with PRO-542.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with PRO-542.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with PRO-542.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with PRO-542.
Digoxin Immune Fab (Ovine) The risk or severity of adverse effects can be increased when Digoxin Immune Fab (Ovine) is combined with PRO-542.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with PRO-542.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with PRO-542.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with PRO-542.
Capromab pendetide The risk or severity of adverse effects can be increased when Capromab pendetide is combined with PRO-542.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with PRO-542.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with PRO-542.
Natalizumab The risk or severity of adverse effects can be increased when Natalizumab is combined with PRO-542.
Palivizumab The risk or severity of adverse effects can be increased when Palivizumab is combined with PRO-542.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with PRO-542.
Bevacizumab The risk or severity of adverse effects can be increased when Bevacizumab is combined with PRO-542.
Technetium Tc-99m arcitumomab The risk or severity of adverse effects can be increased when Technetium Tc-99m arcitumomab is combined with PRO-542.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with PRO-542.
Panitumumab The risk or severity of adverse effects can be increased when Panitumumab is combined with PRO-542.
Ranibizumab The risk or severity of adverse effects can be increased when Ranibizumab is combined with PRO-542.
Galiximab The risk or severity of adverse effects can be increased when Galiximab is combined with PRO-542.
Pexelizumab The risk or severity of adverse effects can be increased when Pexelizumab is combined with PRO-542.
Afelimomab The risk or severity of adverse effects can be increased when Afelimomab is combined with PRO-542.
Epratuzumab The risk or severity of adverse effects can be increased when Epratuzumab is combined with PRO-542.
Bectumomab The risk or severity of adverse effects can be increased when Bectumomab is combined with PRO-542.
Oregovomab The risk or severity of adverse effects can be increased when Oregovomab is combined with PRO-542.
IGN311 The risk or severity of adverse effects can be increased when IGN311 is combined with PRO-542.
Adecatumumab The risk or severity of adverse effects can be increased when Adecatumumab is combined with PRO-542.
Labetuzumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with PRO-542.
Matuzumab The risk or severity of adverse effects can be increased when Matuzumab is combined with PRO-542.
Fontolizumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with PRO-542.
Bavituximab The risk or severity of adverse effects can be increased when Bavituximab is combined with PRO-542.
CR002 The risk or severity of adverse effects can be increased when CR002 is combined with PRO-542.
Rozrolimupab The risk or severity of adverse effects can be increased when Rozrolimupab is combined with PRO-542.
Girentuximab The risk or severity of adverse effects can be increased when Girentuximab is combined with PRO-542.
Obiltoxaximab The risk or severity of adverse effects can be increased when Obiltoxaximab is combined with PRO-542.
XTL-001 The risk or severity of adverse effects can be increased when XTL-001 is combined with PRO-542.
NAV 1800 The risk or severity of adverse effects can be increased when NAV 1800 is combined with PRO-542.
Briakinumab The risk or severity of adverse effects can be increased when Briakinumab is combined with PRO-542.
Otelixizumab The risk or severity of adverse effects can be increased when Otelixizumab is combined with PRO-542.
AMG 108 The risk or severity of adverse effects can be increased when AMG 108 is combined with PRO-542.
Iratumumab The risk or severity of adverse effects can be increased when Iratumumab is combined with PRO-542.
Enokizumab The risk or severity of adverse effects can be increased when Enokizumab is combined with PRO-542.
Ramucirumab The risk or severity of adverse effects can be increased when Ramucirumab is combined with PRO-542.
Farletuzumab The risk or severity of adverse effects can be increased when Farletuzumab is combined with PRO-542.
Veltuzumab The risk or severity of adverse effects can be increased when Veltuzumab is combined with PRO-542.
Ustekinumab The risk or severity of adverse effects can be increased when Ustekinumab is combined with PRO-542.
Trastuzumab emtansine The risk or severity of adverse effects can be increased when Trastuzumab emtansine is combined with PRO-542.
TNX-901 The risk or severity of adverse effects can be increased when PRO-542 is combined with TNX-901.
Inotuzumab ozogamicin The risk or severity of adverse effects can be increased when PRO-542 is combined with Inotuzumab ozogamicin.
RI 624 The risk or severity of adverse effects can be increased when PRO-542 is combined with RI 624.
Stamulumab The risk or severity of adverse effects can be increased when PRO-542 is combined with MYO-029.
CT-011 The risk or severity of adverse effects can be increased when PRO-542 is combined with CT-011.
Leronlimab The risk or severity of adverse effects can be increased when PRO-542 is combined with Leronlimab.
Glembatumumab vedotin The risk or severity of adverse effects can be increased when PRO-542 is combined with Glembatumumab vedotin.
Olaratumab The risk or severity of adverse effects can be increased when PRO-542 is combined with Olaratumab.
IPH 2101 The risk or severity of adverse effects can be increased when PRO-542 is combined with IPH 2101.
TB-402 The risk or severity of adverse effects can be increased when PRO-542 is combined with TB-402.
Caplacizumab The risk or severity of adverse effects can be increased when PRO-542 is combined with Caplacizumab.
IMC-1C11 The risk or severity of adverse effects can be increased when PRO-542 is combined with IMC-1C11.
Eldelumab The risk or severity of adverse effects can be increased when PRO-542 is combined with Eldelumab.
Lumiliximab The risk or severity of adverse effects can be increased when PRO-542 is combined with Lumiliximab.
Canakinumab The risk or severity of adverse effects can be increased when PRO-542 is combined with Canakinumab.

Target Protein

Free fatty acid receptor 4 FFAR4

Referensi & Sumber

Artikel (PubMed)
  • PMID: 15892586
    Castagna A, Biswas P, Beretta A, Lazzarin A: The appealing story of HIV entry inhibitors : from discovery of biological mechanisms to drug development. Drugs. 2005;65(7):879-904.
  • PMID: 14742190
    Jacobson JM, Israel RJ, Lowy I, Ostrow NA, Vassilatos LS, Barish M, Tran DN, Sullivan BM, Ketas TJ, O'Neill TJ, Nagashima KA, Huang W, Petropoulos CJ, Moore JP, Maddon PJ, Olson WC: Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542. Antimicrob Agents Chemother. 2004 Feb;48(2):423-9.

Contoh Produk & Brand

Produk: 0 • International brands: 0
Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul