Andrographolide

DB05767

small molecule investigational

Deskripsi

Andrographolide (HMPL-004) is a botanical product extracted from a herb that occurs naturally in China. The herb has an extensive history of use in TCM for the treatment of upper respiratory tract infections and other inflammatory and infectious diseases.

Struktur Molekul 2D

Berat 350.455
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

417 Data
Apixaban The risk or severity of adverse effects can be increased when Andrographolide is combined with Apixaban.
Dasatinib Dasatinib may increase the anticoagulant activities of Andrographolide.
Ursodeoxycholic acid The risk or severity of adverse effects can be increased when Andrographolide is combined with Ursodeoxycholic acid.
Glycochenodeoxycholic Acid The risk or severity of adverse effects can be increased when Andrographolide is combined with Glycochenodeoxycholic Acid.
Cholic Acid The risk or severity of adverse effects can be increased when Andrographolide is combined with Cholic Acid.
Glycocholic acid The risk or severity of adverse effects can be increased when Andrographolide is combined with Glycocholic acid.
Deoxycholic acid The risk or severity of adverse effects can be increased when Andrographolide is combined with Deoxycholic acid.
Taurocholic acid The risk or severity of adverse effects can be increased when Andrographolide is combined with Taurocholic acid.
Obeticholic acid The risk or severity of adverse effects can be increased when Andrographolide is combined with Obeticholic acid.
Chenodeoxycholic acid The risk or severity of adverse effects can be increased when Andrographolide is combined with Chenodeoxycholic acid.
Taurochenodeoxycholic acid The risk or severity of adverse effects can be increased when Andrographolide is combined with Taurochenodeoxycholic acid.
Tauroursodeoxycholic acid The risk or severity of adverse effects can be increased when Andrographolide is combined with Tauroursodeoxycholic acid.
Bamet-UD2 The risk or severity of adverse effects can be increased when Andrographolide is combined with Bamet-UD2.
Dehydrocholic acid The risk or severity of adverse effects can be increased when Andrographolide is combined with Dehydrocholic acid.
Hyodeoxycholic Acid The risk or severity of adverse effects can be increased when Andrographolide is combined with Hyodeoxycholic Acid.
Glucosamine Glucosamine may increase the antiplatelet activities of Andrographolide.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Andrographolide is combined with Ibritumomab tiuxetan.
Ibrutinib The risk or severity of adverse effects can be increased when Ibrutinib is combined with Andrographolide.
Obinutuzumab The risk or severity of adverse effects can be increased when Andrographolide is combined with Obinutuzumab.
Pentoxifylline Pentoxifylline may increase the antiplatelet activities of Andrographolide.
Rivaroxaban Andrographolide may increase the anticoagulant activities of Rivaroxaban.
Tipranavir Tipranavir may increase the antiplatelet activities of Andrographolide.
Urokinase Andrographolide may increase the anticoagulant activities of Urokinase.
Vitamin E Vitamin E may increase the antiplatelet activities of Andrographolide.
Pentosan polysulfate The risk or severity of adverse effects can be increased when Pentosan polysulfate is combined with Andrographolide.
Limaprost Limaprost may increase the antiplatelet activities of Andrographolide.
Omega-3 fatty acids Omega-3 fatty acids may increase the antiplatelet activities of Andrographolide.
Tositumomab The risk or severity of adverse effects can be increased when Andrographolide is combined with Tositumomab.
Lepirudin The risk or severity of bleeding can be increased when Andrographolide is combined with Lepirudin.
Bivalirudin The risk or severity of bleeding can be increased when Andrographolide is combined with Bivalirudin.
Alteplase The risk or severity of bleeding can be increased when Andrographolide is combined with Alteplase.
Reteplase The risk or severity of bleeding can be increased when Andrographolide is combined with Reteplase.
Anistreplase The risk or severity of bleeding can be increased when Andrographolide is combined with Anistreplase.
Tenecteplase The risk or severity of bleeding can be increased when Andrographolide is combined with Tenecteplase.
Abciximab The risk or severity of bleeding can be increased when Andrographolide is combined with Abciximab.
Drotrecogin alfa The risk or severity of bleeding can be increased when Andrographolide is combined with Drotrecogin alfa.
Streptokinase The risk or severity of bleeding can be increased when Andrographolide is combined with Streptokinase.
Dicoumarol The risk or severity of bleeding can be increased when Andrographolide is combined with Dicoumarol.
Argatroban The risk or severity of bleeding can be increased when Andrographolide is combined with Argatroban.
Ardeparin The risk or severity of bleeding can be increased when Andrographolide is combined with Ardeparin.
Phenindione The risk or severity of bleeding can be increased when Andrographolide is combined with Phenindione.
Fondaparinux The risk or severity of bleeding can be increased when Andrographolide is combined with Fondaparinux.
Warfarin The risk or severity of bleeding can be increased when Andrographolide is combined with Warfarin.
Phenprocoumon The risk or severity of bleeding can be increased when Andrographolide is combined with Phenprocoumon.
Dipyridamole The risk or severity of bleeding can be increased when Andrographolide is combined with Dipyridamole.
Heparin The risk or severity of bleeding can be increased when Andrographolide is combined with Heparin.
Enoxaparin The risk or severity of bleeding can be increased when Andrographolide is combined with Enoxaparin.
Epoprostenol The risk or severity of bleeding can be increased when Andrographolide is combined with Epoprostenol.
Acenocoumarol The risk or severity of bleeding can be increased when Andrographolide is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of bleeding can be increased when Andrographolide is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of bleeding can be increased when Andrographolide is combined with Coumarin.
Ximelagatran The risk or severity of bleeding can be increased when Andrographolide is combined with Ximelagatran.
Desmoteplase The risk or severity of bleeding can be increased when Andrographolide is combined with Desmoteplase.
Defibrotide The risk or severity of bleeding can be increased when Andrographolide is combined with Defibrotide.
Ancrod The risk or severity of bleeding can be increased when Andrographolide is combined with Ancrod.
Beraprost The risk or severity of bleeding can be increased when Andrographolide is combined with Beraprost.
Prasugrel The risk or severity of bleeding can be increased when Andrographolide is combined with Prasugrel.
Sulodexide The risk or severity of bleeding can be increased when Andrographolide is combined with Sulodexide.
Semuloparin The risk or severity of bleeding can be increased when Andrographolide is combined with Semuloparin.
Idraparinux The risk or severity of bleeding can be increased when Andrographolide is combined with Idraparinux.
Cangrelor The risk or severity of bleeding can be increased when Andrographolide is combined with Cangrelor.
Astaxanthin The risk or severity of bleeding can be increased when Andrographolide is combined with Astaxanthin.
Otamixaban The risk or severity of bleeding can be increased when Andrographolide is combined with Otamixaban.
Amediplase The risk or severity of bleeding can be increased when Andrographolide is combined with Amediplase.
Danaparoid The risk or severity of bleeding can be increased when Andrographolide is combined with Danaparoid.
Dalteparin The risk or severity of bleeding can be increased when Andrographolide is combined with Dalteparin.
Tinzaparin The risk or severity of bleeding can be increased when Andrographolide is combined with Tinzaparin.
(R)-warfarin The risk or severity of bleeding can be increased when Andrographolide is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of bleeding can be increased when Andrographolide is combined with Ethyl biscoumacetate.
Nadroparin The risk or severity of bleeding can be increased when Andrographolide is combined with Nadroparin.
Triflusal The risk or severity of bleeding can be increased when Andrographolide is combined with Triflusal.
Ticagrelor The risk or severity of bleeding can be increased when Andrographolide is combined with Ticagrelor.
Ditazole The risk or severity of bleeding can be increased when Andrographolide is combined with Ditazole.
Vorapaxar The risk or severity of bleeding can be increased when Andrographolide is combined with Vorapaxar.
Edoxaban The risk or severity of bleeding can be increased when Andrographolide is combined with Edoxaban.
Sodium citrate The risk or severity of bleeding can be increased when Andrographolide is combined with Sodium citrate.
Dextran The risk or severity of bleeding can be increased when Andrographolide is combined with Dextran.
Bemiparin The risk or severity of bleeding can be increased when Andrographolide is combined with Bemiparin.
Parnaparin The risk or severity of bleeding can be increased when Andrographolide is combined with Parnaparin.
Desirudin The risk or severity of bleeding can be increased when Andrographolide is combined with Desirudin.
Antithrombin Alfa The risk or severity of bleeding can be increased when Andrographolide is combined with Antithrombin Alfa.
Protein C The risk or severity of bleeding can be increased when Andrographolide is combined with Protein C.
Antithrombin III human The risk or severity of bleeding can be increased when Andrographolide is combined with Antithrombin III human.
Letaxaban The risk or severity of bleeding can be increased when Andrographolide is combined with Letaxaban.
Darexaban The risk or severity of bleeding can be increased when Andrographolide is combined with Darexaban.
Betrixaban The risk or severity of bleeding can be increased when Andrographolide is combined with Betrixaban.
Nafamostat The risk or severity of bleeding can be increased when Andrographolide is combined with Nafamostat.
Monteplase The risk or severity of bleeding can be increased when Andrographolide is combined with Monteplase.
Gabexate The risk or severity of bleeding can be increased when Andrographolide is combined with Gabexate.
Fluindione The risk or severity of bleeding can be increased when Andrographolide is combined with Fluindione.
Protein S human The risk or severity of bleeding can be increased when Andrographolide is combined with Protein S human.
Brinase The risk or severity of bleeding can be increased when Andrographolide is combined with Brinase.
Clorindione The risk or severity of bleeding can be increased when Andrographolide is combined with Clorindione.
Diphenadione The risk or severity of bleeding can be increased when Andrographolide is combined with Diphenadione.
Tioclomarol The risk or severity of bleeding can be increased when Andrographolide is combined with Tioclomarol.
Melagatran The risk or severity of bleeding can be increased when Andrographolide is combined with Melagatran.
Saruplase The risk or severity of bleeding can be increased when Andrographolide is combined with Saruplase.
(S)-Warfarin The risk or severity of bleeding can be increased when Andrographolide is combined with (S)-Warfarin.
Tocopherylquinone The risk or severity of bleeding can be increased when Andrographolide is combined with Tocopherylquinone.
Dabigatran The risk or severity of bleeding can be increased when Andrographolide is combined with Dabigatran.

Target Protein

Tumor necrosis factor TNF
Interleukin-1 beta IL1B
Interleukin-6 IL6
Nuclear factor NF-kappa-B p100 subunit NFKB2
Nuclear factor NF-kappa-B p105 subunit NFKB1

Referensi & Sumber

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Sekuens Gen/Protein (FASTA)

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