Gantacurium

DB05710

small molecule investigational

Deskripsi

Gantacurium chloride is a new, investigational, non-depolarizing ultra-short acting neuromuscular blocker. It is being developed by Avera Pharmaceuticals.

Struktur Molekul 2D

Berat 993.58
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) 3.09±0.21 minutes
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

The pharmacokinetic parameters are consistent with in situ rapid inactivation by plasma cysteine.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

879 Data
Buprenorphine Gantacurium may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Gantacurium.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Gantacurium.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Gantacurium.
Hydrocodone Gantacurium may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Gantacurium.
Magnesium sulfate The therapeutic efficacy of Gantacurium can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Gantacurium may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Gantacurium may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Gantacurium.
Mirtazapine Gantacurium may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Gantacurium.
Orphenadrine Gantacurium may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Gantacurium may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Gantacurium.
Pramipexole Gantacurium may increase the sedative activities of Pramipexole.
Ropinirole Gantacurium may increase the sedative activities of Ropinirole.
Rotigotine Gantacurium may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Gantacurium.
Sodium oxybate Gantacurium may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Gantacurium may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Gantacurium.
Thalidomide Gantacurium may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Gantacurium may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Secretin porcine The therapeutic efficacy of Secretin porcine can be decreased when used in combination with Gantacurium.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Gantacurium.
Botulinum toxin type A The risk or severity of adverse effects can be increased when Gantacurium is combined with Botulinum toxin type A.
Botulinum toxin type B The risk or severity of adverse effects can be increased when Gantacurium is combined with Botulinum toxin type B.
Ethanol Gantacurium may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Gantacurium may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Gantacurium.
Fluvoxamine The risk or severity of adverse effects can be increased when Gantacurium is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Gantacurium is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Gantacurium is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Gantacurium is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Gantacurium is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Gantacurium is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Gantacurium is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Gantacurium is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Gantacurium is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Gantacurium is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Gantacurium is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Gantacurium is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Gantacurium is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Gantacurium is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Gantacurium is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Gantacurium is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Gantacurium is combined with Alaproclate.
Morphine The risk or severity of adverse effects can be increased when Gantacurium is combined with Morphine.
Codeine The risk or severity of adverse effects can be increased when Gantacurium is combined with Codeine.
Hydromorphone The risk or severity of adverse effects can be increased when Gantacurium is combined with Hydromorphone.
Meperidine The risk or severity of adverse effects can be increased when Gantacurium is combined with Meperidine.
Oxycodone The risk or severity of adverse effects can be increased when Gantacurium is combined with Oxycodone.
Butorphanol The risk or severity of adverse effects can be increased when Gantacurium is combined with Butorphanol.
Dextropropoxyphene The risk or severity of adverse effects can be increased when Gantacurium is combined with Dextropropoxyphene.
Pentazocine The risk or severity of adverse effects can be increased when Gantacurium is combined with Pentazocine.
Sufentanil The risk or severity of adverse effects can be increased when Gantacurium is combined with Sufentanil.
Alfentanil The risk or severity of adverse effects can be increased when Gantacurium is combined with Alfentanil.
Fentanyl The risk or severity of adverse effects can be increased when Gantacurium is combined with Fentanyl.
Nalbuphine The risk or severity of adverse effects can be increased when Gantacurium is combined with Nalbuphine.
Levorphanol The risk or severity of adverse effects can be increased when Gantacurium is combined with Levorphanol.
Remifentanil The risk or severity of adverse effects can be increased when Gantacurium is combined with Remifentanil.
Diphenoxylate The risk or severity of adverse effects can be increased when Gantacurium is combined with Diphenoxylate.
Oxymorphone The risk or severity of adverse effects can be increased when Gantacurium is combined with Oxymorphone.
Dezocine The risk or severity of adverse effects can be increased when Gantacurium is combined with Dezocine.
Levacetylmethadol The risk or severity of adverse effects can be increased when Gantacurium is combined with Levacetylmethadol.
Methadyl acetate The risk or severity of adverse effects can be increased when Gantacurium is combined with Methadyl acetate.
Dihydroetorphine The risk or severity of adverse effects can be increased when Gantacurium is combined with Dihydroetorphine.
Diamorphine The risk or severity of adverse effects can be increased when Gantacurium is combined with Diamorphine.
Ethylmorphine The risk or severity of adverse effects can be increased when Gantacurium is combined with Ethylmorphine.
Etorphine The risk or severity of adverse effects can be increased when Gantacurium is combined with Etorphine.
Dextromoramide The risk or severity of adverse effects can be increased when Gantacurium is combined with Dextromoramide.
Desomorphine The risk or severity of adverse effects can be increased when Gantacurium is combined with Desomorphine.
Carfentanil The risk or severity of adverse effects can be increased when Gantacurium is combined with Carfentanil.
Dihydrocodeine The risk or severity of adverse effects can be increased when Gantacurium is combined with Dihydrocodeine.
Alphacetylmethadol The risk or severity of adverse effects can be increased when Gantacurium is combined with Alphacetylmethadol.
Dihydromorphine The risk or severity of adverse effects can be increased when Gantacurium is combined with Dihydromorphine.
Ketobemidone The risk or severity of adverse effects can be increased when Gantacurium is combined with Ketobemidone.
DPDPE The risk or severity of adverse effects can be increased when Gantacurium is combined with DPDPE.
Lofentanil The risk or severity of adverse effects can be increased when Gantacurium is combined with Lofentanil.
Opium The risk or severity of adverse effects can be increased when Gantacurium is combined with Opium.
Normethadone The risk or severity of adverse effects can be increased when Gantacurium is combined with Normethadone.
Piritramide The risk or severity of adverse effects can be increased when Gantacurium is combined with Piritramide.
Alphaprodine The risk or severity of adverse effects can be increased when Gantacurium is combined with Alphaprodine.
Meptazinol The risk or severity of adverse effects can be increased when Gantacurium is combined with Meptazinol.
Phenoperidine The risk or severity of adverse effects can be increased when Gantacurium is combined with Phenoperidine.
Phenazocine The risk or severity of adverse effects can be increased when Gantacurium is combined with Phenazocine.
Tilidine The risk or severity of adverse effects can be increased when Gantacurium is combined with Tilidine.
Carfentanil, C-11 The risk or severity of adverse effects can be increased when Gantacurium is combined with Carfentanil, C-11.
Naltrexone The risk or severity of adverse effects can be increased when Gantacurium is combined with Naltrexone.
Bezitramide The risk or severity of adverse effects can be increased when Gantacurium is combined with Bezitramide.
Nicomorphine The risk or severity of adverse effects can be increased when Gantacurium is combined with Nicomorphine.
Benzhydrocodone The risk or severity of adverse effects can be increased when Gantacurium is combined with Benzhydrocodone.
Naloxegol The risk or severity of adverse effects can be increased when Gantacurium is combined with Naloxegol.
Mecamylamine The risk or severity of adverse effects can be increased when Mecamylamine is combined with Gantacurium.
Tropicamide The risk or severity of adverse effects can be increased when Tropicamide is combined with Gantacurium.
Amantadine The risk or severity of adverse effects can be increased when Amantadine is combined with Gantacurium.
Cyclopentolate The risk or severity of adverse effects can be increased when Cyclopentolate is combined with Gantacurium.
Pentolinium The risk or severity of adverse effects can be increased when Pentolinium is combined with Gantacurium.
Trimethaphan The risk or severity of adverse effects can be increased when Trimethaphan is combined with Gantacurium.

Target Protein

Neuronal acetylcholine receptor subunit alpha-3 CHRNA3

Referensi & Sumber

Artikel (PubMed)
  • PMID: 15087619
    Heerdt PM, Kang R, The' A, Hashim M, Mook RJ Jr, Savarese JJ: Cardiopulmonary effects of the novel neuromuscular blocking drug GW280430A (AV430A) in dogs. Anesthesiology. 2004 Apr;100(4):846-51.
  • PMID: 15087618
    Savarese JJ, Belmont MR, Hashim MA, Mook RA Jr, Boros EE, Samano V, Patel SS, Feldman PL, Schultz JA, McNulty M, Spitzer T, Cohn DL, Morgan P, Wastila WB: Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: a comparison with mivacurium. Anesthesiology. 2004 Apr;100(4):835-45.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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