BL-1020

DB05687

small molecule investigational

Deskripsi

BL-1020 is a first in class novel compound for the treatment of schizophrenia. It is being developed by BioLineRx (BioLine).

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Orally available.

Metabolisme

BL-1020, after oral administration, crosses the blood brain barrier intact and is metabolized to GABA and perphenazine.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

824 Data
Buprenorphine BL-1020 may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of BL-1020.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of BL-1020.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of BL-1020.
Hydrocodone BL-1020 may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of BL-1020.
Magnesium sulfate The therapeutic efficacy of BL-1020 can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine BL-1020 may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of BL-1020.
Mirtazapine BL-1020 may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of BL-1020.
Orphenadrine BL-1020 may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde BL-1020 may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of BL-1020.
Pramipexole BL-1020 may increase the sedative activities of Pramipexole.
Ropinirole BL-1020 may increase the sedative activities of Ropinirole.
Rotigotine BL-1020 may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with BL-1020.
Sodium oxybate BL-1020 may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant BL-1020 may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of BL-1020.
Thalidomide BL-1020 may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem BL-1020 may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Amisulpride BL-1020 may increase the antipsychotic activities of Amisulpride.
Methylphenidate The risk or severity of adverse effects can be increased when BL-1020 is combined with Methylphenidate.
Dexmethylphenidate The risk or severity of adverse effects can be increased when BL-1020 is combined with Dexmethylphenidate.
Metoclopramide The risk or severity of adverse effects can be increased when Metoclopramide is combined with BL-1020.
Quinagolide The therapeutic efficacy of Quinagolide can be decreased when used in combination with BL-1020.
Sulpiride BL-1020 may increase the antipsychotic activities of Sulpiride.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with BL-1020.
Lithium citrate Lithium citrate may increase the neurotoxic activities of BL-1020.
Lithium hydroxide Lithium hydroxide may increase the neurotoxic activities of BL-1020.
Mequitazine BL-1020 may increase the arrhythmogenic activities of Mequitazine.
Tetrabenazine The risk or severity of adverse effects can be increased when BL-1020 is combined with Tetrabenazine.
Deutetrabenazine The risk or severity of adverse effects can be increased when BL-1020 is combined with Deutetrabenazine.
Thiopental The risk or severity of adverse effects can be increased when BL-1020 is combined with Thiopental.
Metyrosine The risk or severity of extrapyramidal symptoms and CNS depression can be increased when Metyrosine is combined with BL-1020.
Ethanol BL-1020 may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine BL-1020 may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of BL-1020.
Fluvoxamine The risk or severity of adverse effects can be increased when BL-1020 is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when BL-1020 is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when BL-1020 is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when BL-1020 is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when BL-1020 is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when BL-1020 is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when BL-1020 is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when BL-1020 is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when BL-1020 is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when BL-1020 is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when BL-1020 is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when BL-1020 is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when BL-1020 is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when BL-1020 is combined with Seproxetine.
Levomilnacipran The risk or severity of adverse effects can be increased when Levomilnacipran is combined with BL-1020.
Indalpine The risk or severity of adverse effects can be increased when BL-1020 is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when BL-1020 is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when BL-1020 is combined with Alaproclate.
Esmolol The serum concentration of Esmolol can be increased when it is combined with BL-1020.
Betaxolol The serum concentration of Betaxolol can be increased when it is combined with BL-1020.
Metoprolol The serum concentration of Metoprolol can be increased when it is combined with BL-1020.
Atenolol The serum concentration of Atenolol can be increased when it is combined with BL-1020.
Timolol The serum concentration of Timolol can be increased when it is combined with BL-1020.
Sotalol The serum concentration of Sotalol can be increased when it is combined with BL-1020.
Propranolol The serum concentration of Propranolol can be increased when it is combined with BL-1020.
Labetalol The serum concentration of Labetalol can be increased when it is combined with BL-1020.
Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with BL-1020.
Alprenolol The serum concentration of Alprenolol can be increased when it is combined with BL-1020.
Pindolol The serum concentration of Pindolol can be increased when it is combined with BL-1020.
Carvedilol The serum concentration of Carvedilol can be increased when it is combined with BL-1020.
Propafenone The serum concentration of Propafenone can be increased when it is combined with BL-1020.
Acebutolol The serum concentration of Acebutolol can be increased when it is combined with BL-1020.
Nadolol The serum concentration of Nadolol can be increased when it is combined with BL-1020.
Bevantolol The serum concentration of Bevantolol can be increased when it is combined with BL-1020.
Practolol The serum concentration of Practolol can be increased when it is combined with BL-1020.
Penbutolol The serum concentration of Penbutolol can be increased when it is combined with BL-1020.
Oxprenolol The serum concentration of Oxprenolol can be increased when it is combined with BL-1020.
Dexpropranolol The serum concentration of Dexpropranolol can be increased when it is combined with BL-1020.
Celiprolol The serum concentration of Celiprolol can be increased when it is combined with BL-1020.
Nebivolol The serum concentration of Nebivolol can be increased when it is combined with BL-1020.
Bufuralol The serum concentration of Bufuralol can be increased when it is combined with BL-1020.
Bopindolol The serum concentration of Bopindolol can be increased when it is combined with BL-1020.
Bupranolol The serum concentration of Bupranolol can be increased when it is combined with BL-1020.
Indenolol The serum concentration of Indenolol can be increased when it is combined with BL-1020.
Arotinolol The serum concentration of Arotinolol can be increased when it is combined with BL-1020.
Levobetaxolol The serum concentration of Levobetaxolol can be increased when it is combined with BL-1020.
Talinolol The serum concentration of Talinolol can be increased when it is combined with BL-1020.
Anisodamine The serum concentration of Anisodamine can be increased when it is combined with BL-1020.
Bucindolol The serum concentration of Bucindolol can be increased when it is combined with BL-1020.
Esatenolol The serum concentration of Esatenolol can be increased when it is combined with BL-1020.
Cloranolol The serum concentration of Cloranolol can be increased when it is combined with BL-1020.
Mepindolol The serum concentration of Mepindolol can be increased when it is combined with BL-1020.
Epanolol The serum concentration of Epanolol can be increased when it is combined with BL-1020.
Tertatolol The serum concentration of Tertatolol can be increased when it is combined with BL-1020.
Landiolol The serum concentration of Landiolol can be increased when it is combined with BL-1020.
Morphine The risk or severity of hypotension and CNS depression can be increased when BL-1020 is combined with Morphine.
Codeine The risk or severity of hypotension and CNS depression can be increased when BL-1020 is combined with Codeine.
Hydromorphone The risk or severity of hypotension and CNS depression can be increased when BL-1020 is combined with Hydromorphone.
Meperidine The risk or severity of hypotension and CNS depression can be increased when BL-1020 is combined with Meperidine.
Oxycodone The risk or severity of hypotension and CNS depression can be increased when BL-1020 is combined with Oxycodone.

Target Protein

D(2) dopamine receptor DRD2
5-hydroxytryptamine receptor 2A HTR2A

Referensi & Sumber

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Sekuens Gen/Protein (FASTA)

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