Alanosine

DB05540

small molecule investigational

Deskripsi

An amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities.

Struktur Molekul 2D

Berat 149.1054
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

40 Data
Technetium Tc-99m oxidronate Alanosine may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Alanosine.
Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Alanosine.
Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Alanosine.
Methoxy polyethylene glycol-epoetin beta The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Alanosine.
Lidocaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Quinisocaine.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Alanosine.
Ambroxol The risk or severity of methemoglobinemia can be increased when Alanosine is combined with Ambroxol.
Etrasimod The risk or severity of immunosuppression can be increased when Alanosine is combined with Etrasimod.

Target Protein

Aspartate carbamoyltransferase catalytic subunit pyrB
Adenylosuccinate synthetase isozyme 2 ADSS2
Adenylosuccinate synthetase isozyme 1 ADSS1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 18618081
    Kindler HL, Burris HA 3rd, Sandler AB, Oliff IA: A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer. Invest New Drugs. 2009 Feb;27(1):75-81. doi: 10.1007/s10637-008-9160-1. Epub 2008 Jul 11.
  • PMID: 16103098
    Huang Y, Dai Z, Barbacioru C, Sadee W: Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance. Cancer Res. 2005 Aug 15;65(16):7446-54.

Contoh Produk & Brand

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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