Pelitinib

DB05524

small molecule investigational

Deskripsi

Pelitinib (EKB-569) is a potent, low molecular weight, selective, and irreversible inhibitor of epidermal growth factor receptor (EGFR) that is being developed as an anticancer agent.

Struktur Molekul 2D

Berat 467.93
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

39 Data
Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Pelitinib.
Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Pelitinib.
Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Pelitinib.
Methoxy polyethylene glycol-epoetin beta The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Pelitinib.
Lidocaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Quinisocaine.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Pelitinib.
Ambroxol The risk or severity of methemoglobinemia can be increased when Pelitinib is combined with Ambroxol.
Etrasimod The risk or severity of immunosuppression can be increased when Pelitinib is combined with Etrasimod.

Target Protein

Epidermal growth factor receptor EGFR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 16364494
    Yoshimura N, Kudoh S, Kimura T, Mitsuoka S, Matsuura K, Hirata K, Matsui K, Negoro S, Nakagawa K, Fukuoka M: EKB-569, a new irreversible epidermal growth factor receptor tyrosine kinase inhibitor, with clinical activity in patients with non-small cell lung cancer with acquired resistance to gefitinib. Lung Cancer. 2006 Mar;51(3):363-8. Epub 2005 Dec 20.
  • PMID: 18053062
    Palayekar MJ, Herzog TJ: The emerging role of epidermal growth factor receptor inhibitors in ovarian cancer. Int J Gynecol Cancer. 2008 Sep-Oct;18(5):879-90. Epub 2007 Dec 5.

Contoh Produk & Brand

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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