Pimagedine has been developed by Synvista Therapeutics, Inc for the treatment of diabetic kidney disease. It is an advanced glycation end product inhibitor which manages diabetic nephropathy, either alone or in combination with other therapies. It is beneficial in treating patients with diabetic nephropathy.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Tipiracil | The excretion of Tipiracil can be decreased when combined with Pimagedine. |
| Varenicline | The excretion of Varenicline can be decreased when combined with Pimagedine. |
| Prazosin | The serum concentration of Prazosin can be increased when it is combined with Pimagedine. |
| Solriamfetol | The serum concentration of Solriamfetol can be increased when it is combined with Pimagedine. |
| Ranitidine | The serum concentration of Ranitidine can be increased when it is combined with Pimagedine. |
| Linagliptin | The serum concentration of Linagliptin can be increased when it is combined with Pimagedine. |
| Choline salicylate | The serum concentration of Choline salicylate can be increased when it is combined with Pimagedine. |
| Choline | The serum concentration of Choline can be increased when it is combined with Pimagedine. |
| Metformin | The serum concentration of Metformin can be increased when it is combined with Pimagedine. |
| Norepinephrine | The serum concentration of Norepinephrine can be increased when it is combined with Pimagedine. |
| Reserpine | The serum concentration of Reserpine can be increased when it is combined with Pimagedine. |
| Pramipexole | The serum concentration of Pramipexole can be increased when it is combined with Pimagedine. |
| Epinephrine | The serum concentration of Epinephrine can be increased when it is combined with Pimagedine. |
| Lamivudine | The serum concentration of Lamivudine can be increased when it is combined with Pimagedine. |
| Amantadine | The serum concentration of Amantadine can be increased when it is combined with Pimagedine. |
| Dopamine | The serum concentration of Dopamine can be increased when it is combined with Pimagedine. |
| Memantine | The serum concentration of Memantine can be increased when it is combined with Pimagedine. |
| Histamine | The serum concentration of Histamine can be increased when it is combined with Pimagedine. |
| Agmatine | The serum concentration of Agmatine can be increased when it is combined with Pimagedine. |
| Nafamostat | The serum concentration of Nafamostat can be increased when it is combined with Pimagedine. |
| Dofetilide | The serum concentration of Dofetilide can be increased when it is combined with Pimagedine. |
| Cisplatin | The serum concentration of Cisplatin can be increased when it is combined with Pimagedine. |
| Oxaliplatin | The serum concentration of Oxaliplatin can be increased when it is combined with Pimagedine. |
| Procainamide | The serum concentration of Procainamide can be increased when it is combined with Pimagedine. |
| Dalfampridine | The serum concentration of Dalfampridine can be increased when it is combined with Pimagedine. |
| Clofarabine | The serum concentration of Clofarabine can be increased when it is combined with Pimagedine. |
| Gentamicin | The serum concentration of Gentamicin can be increased when it is combined with Pimagedine. |