Hepatitis B immune globulin

DB05276

biotech approved investigational

Deskripsi

Long-term hepatitis B immune globulin (HBIG) has been shown to reduce hepatitis B virus (HBV) reinfection in patients transplanted for hepatitis B. Infection with hepatitis B may lead to hepatocellular carcinoma, a type of liver cancer. Therefore, the hepatitis-B vaccines are cancer-preventing vaccines. According to the Centers for Disease Control and Prevention (CDC), the hepatitis B vaccine was the first anti-cancer vaccine.

HBIG is prepared from the plasma of donors who have high antibody levels of the hepatitis B surface antigen. It is extracted from the Cohn fraction II. During the process, viruses are deactivated, and in the final steps, solvents used in the preparation are removed. The preparation is tested for absence of HIV, HCV, herpes virus, and reovirus.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

372 Data
Diethylstilbestrol Diethylstilbestrol may increase the thrombogenic activities of Hepatitis B immune globulin.
Chlorotrianisene Chlorotrianisene may increase the thrombogenic activities of Hepatitis B immune globulin.
Conjugated estrogens Conjugated estrogens may increase the thrombogenic activities of Hepatitis B immune globulin.
Estrone Estrone may increase the thrombogenic activities of Hepatitis B immune globulin.
Estradiol Estradiol may increase the thrombogenic activities of Hepatitis B immune globulin.
Dienestrol Dienestrol may increase the thrombogenic activities of Hepatitis B immune globulin.
Ethinylestradiol Ethinylestradiol may increase the thrombogenic activities of Hepatitis B immune globulin.
Mestranol Mestranol may increase the thrombogenic activities of Hepatitis B immune globulin.
Estriol Estriol may increase the thrombogenic activities of Hepatitis B immune globulin.
Estrone sulfate Estrone sulfate may increase the thrombogenic activities of Hepatitis B immune globulin.
Quinestrol Quinestrol may increase the thrombogenic activities of Hepatitis B immune globulin.
Hexestrol Hexestrol may increase the thrombogenic activities of Hepatitis B immune globulin.
Tibolone Tibolone may increase the thrombogenic activities of Hepatitis B immune globulin.
Synthetic Conjugated Estrogens, A Synthetic Conjugated Estrogens, A may increase the thrombogenic activities of Hepatitis B immune globulin.
Synthetic Conjugated Estrogens, B Synthetic Conjugated Estrogens, B may increase the thrombogenic activities of Hepatitis B immune globulin.
Polyestradiol phosphate Polyestradiol phosphate may increase the thrombogenic activities of Hepatitis B immune globulin.
Esterified estrogens Esterified estrogens may increase the thrombogenic activities of Hepatitis B immune globulin.
Zeranol Zeranol may increase the thrombogenic activities of Hepatitis B immune globulin.
Equol Equol may increase the thrombogenic activities of Hepatitis B immune globulin.
Promestriene Promestriene may increase the thrombogenic activities of Hepatitis B immune globulin.
Methallenestril Methallenestril may increase the thrombogenic activities of Hepatitis B immune globulin.
Epimestrol Epimestrol may increase the thrombogenic activities of Hepatitis B immune globulin.
Moxestrol Moxestrol may increase the thrombogenic activities of Hepatitis B immune globulin.
Estradiol acetate Estradiol acetate may increase the thrombogenic activities of Hepatitis B immune globulin.
Estradiol benzoate Estradiol benzoate may increase the thrombogenic activities of Hepatitis B immune globulin.
Estradiol cypionate Estradiol cypionate may increase the thrombogenic activities of Hepatitis B immune globulin.
Estradiol valerate Estradiol valerate may increase the thrombogenic activities of Hepatitis B immune globulin.
Biochanin A Biochanin A may increase the thrombogenic activities of Hepatitis B immune globulin.
Formononetin Formononetin may increase the thrombogenic activities of Hepatitis B immune globulin.
Estetrol Estetrol may increase the thrombogenic activities of Hepatitis B immune globulin.
Cetuximab The risk or severity of adverse effects can be increased when Cetuximab is combined with Hepatitis B immune globulin.
Human immunoglobulin G The risk or severity of adverse effects can be increased when Human immunoglobulin G is combined with Hepatitis B immune globulin.
Omalizumab The risk or severity of adverse effects can be increased when Omalizumab is combined with Hepatitis B immune globulin.
Adalimumab The risk or severity of adverse effects can be increased when Adalimumab is combined with Hepatitis B immune globulin.
Abciximab The risk or severity of adverse effects can be increased when Abciximab is combined with Hepatitis B immune globulin.
Gemtuzumab ozogamicin The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Hepatitis B immune globulin.
Indium In-111 satumomab pendetide The risk or severity of adverse effects can be increased when Indium In-111 satumomab pendetide is combined with Hepatitis B immune globulin.
Infliximab The risk or severity of adverse effects can be increased when Infliximab is combined with Hepatitis B immune globulin.
Trastuzumab The risk or severity of adverse effects can be increased when Trastuzumab is combined with Hepatitis B immune globulin.
Rituximab The risk or severity of adverse effects can be increased when Rituximab is combined with Hepatitis B immune globulin.
Basiliximab The risk or severity of adverse effects can be increased when Basiliximab is combined with Hepatitis B immune globulin.
Muromonab The risk or severity of adverse effects can be increased when Muromonab is combined with Hepatitis B immune globulin.
Digoxin Immune Fab (Ovine) The risk or severity of adverse effects can be increased when Digoxin Immune Fab (Ovine) is combined with Hepatitis B immune globulin.
Ibritumomab tiuxetan The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Hepatitis B immune globulin.
Tositumomab The risk or severity of adverse effects can be increased when Tositumomab is combined with Hepatitis B immune globulin.
Alemtuzumab The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Hepatitis B immune globulin.
Capromab pendetide The risk or severity of adverse effects can be increased when Capromab pendetide is combined with Hepatitis B immune globulin.
Efalizumab The risk or severity of adverse effects can be increased when Efalizumab is combined with Hepatitis B immune globulin.
Antithymocyte immunoglobulin (rabbit) The risk or severity of adverse effects can be increased when Antithymocyte immunoglobulin (rabbit) is combined with Hepatitis B immune globulin.
Natalizumab The risk or severity of adverse effects can be increased when Natalizumab is combined with Hepatitis B immune globulin.
Palivizumab The risk or severity of adverse effects can be increased when Palivizumab is combined with Hepatitis B immune globulin.
Daclizumab The risk or severity of adverse effects can be increased when Daclizumab is combined with Hepatitis B immune globulin.
Bevacizumab The risk or severity of adverse effects can be increased when Bevacizumab is combined with Hepatitis B immune globulin.
Technetium Tc-99m arcitumomab The risk or severity of adverse effects can be increased when Technetium Tc-99m arcitumomab is combined with Hepatitis B immune globulin.
Eculizumab The risk or severity of adverse effects can be increased when Eculizumab is combined with Hepatitis B immune globulin.
Panitumumab The risk or severity of adverse effects can be increased when Panitumumab is combined with Hepatitis B immune globulin.
Ranibizumab The risk or severity of adverse effects can be increased when Ranibizumab is combined with Hepatitis B immune globulin.
Galiximab The risk or severity of adverse effects can be increased when Galiximab is combined with Hepatitis B immune globulin.
Pexelizumab The risk or severity of adverse effects can be increased when Pexelizumab is combined with Hepatitis B immune globulin.
Afelimomab The risk or severity of adverse effects can be increased when Afelimomab is combined with Hepatitis B immune globulin.
Epratuzumab The risk or severity of adverse effects can be increased when Epratuzumab is combined with Hepatitis B immune globulin.
Bectumomab The risk or severity of adverse effects can be increased when Bectumomab is combined with Hepatitis B immune globulin.
Oregovomab The risk or severity of adverse effects can be increased when Oregovomab is combined with Hepatitis B immune globulin.
IGN311 The risk or severity of adverse effects can be increased when IGN311 is combined with Hepatitis B immune globulin.
Adecatumumab The risk or severity of adverse effects can be increased when Adecatumumab is combined with Hepatitis B immune globulin.
Labetuzumab The risk or severity of adverse effects can be increased when Labetuzumab is combined with Hepatitis B immune globulin.
Matuzumab The risk or severity of adverse effects can be increased when Matuzumab is combined with Hepatitis B immune globulin.
Fontolizumab The risk or severity of adverse effects can be increased when Fontolizumab is combined with Hepatitis B immune globulin.
Bavituximab The risk or severity of adverse effects can be increased when Bavituximab is combined with Hepatitis B immune globulin.
CR002 The risk or severity of adverse effects can be increased when CR002 is combined with Hepatitis B immune globulin.
Rozrolimupab The risk or severity of adverse effects can be increased when Rozrolimupab is combined with Hepatitis B immune globulin.
Girentuximab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Girentuximab.
Obiltoxaximab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Obiltoxaximab.
XTL-001 The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with XTL-001.
NAV 1800 The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with NAV 1800.
Briakinumab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Briakinumab.
Otelixizumab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Otelixizumab.
AMG 108 The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with AMG 108.
Iratumumab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Iratumumab.
Enokizumab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Enokizumab.
Ramucirumab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Ramucirumab.
Farletuzumab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Farletuzumab.
Veltuzumab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Veltuzumab.
Ustekinumab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Ustekinumab.
Trastuzumab emtansine The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Trastuzumab emtansine.
PRO-542 The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with PRO-542.
TNX-901 The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with TNX-901.
Inotuzumab ozogamicin The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Inotuzumab ozogamicin.
RI 624 The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with RI 624.
Stamulumab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with MYO-029.
CT-011 The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with CT-011.
Leronlimab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Leronlimab.
Glembatumumab vedotin The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Glembatumumab vedotin.
Olaratumab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Olaratumab.
IPH 2101 The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with IPH 2101.
TB-402 The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with TB-402.
Caplacizumab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Caplacizumab.
IMC-1C11 The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with IMC-1C11.
Eldelumab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Eldelumab.
Lumiliximab The risk or severity of adverse effects can be increased when Hepatitis B immune globulin is combined with Lumiliximab.

Target Protein

HBsAg S gene

Referensi & Sumber

Artikel (PubMed)
  • PMID: 9425940
    Ghany MG, Ayola B, Villamil FG, Gish RG, Rojter S, Vierling JM, Lok AS: Hepatitis B virus S mutants in liver transplant recipients who were reinfected despite hepatitis B immune globulin prophylaxis. Hepatology. 1998 Jan;27(1):213-22.

Contoh Produk & Brand

Produk: 33 • International brands: 0
Produk
  • H-big
    Liquid • 1.5 unit / mL • Intramuscular • Canada • Approved
  • HepaGam B
    Solution • 312 [iU]/1mL • Intramuscular; Intravenous • US • Approved
  • HepaGam B
    Solution • 312 [iU]/1mL • Intramuscular; Intravenous • US • Approved
  • HepaGam B
    Injection, solution • 50 mg/1mL • Intramuscular; Intravenous • US • Approved
  • HepaGam B
    Injection, solution • 50 mg/1mL • Intramuscular; Intravenous • US • Approved
  • HepaGam B
    Injection, solution • 312 [iU]/1mL • Intramuscular; Intravenous • US • Approved
  • HepaGam B
    Injection, solution • 312 [iU]/1mL • Intramuscular; Intravenous • US • Approved
  • HepaGam B
    Injection, solution • 312 [iU]/1mL • Intramuscular; Intravenous • US • Approved
Menampilkan 8 dari 33 produk.

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