Peringatan Keamanan

Acute oral toxicity (LD50) in rat is 10001 mg/kg.

Silver sulfadiazine

DB05245

small molecule approved vet_approved

Deskripsi

Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns.

Struktur Molekul 2D

Berat 357.137
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

54 Data
Magnesium The serum concentration of Magnesium can be decreased when it is combined with Silver sulfadiazine.
Benzylpenicillin Silver sulfadiazine may decrease the excretion rate of Benzylpenicillin which could result in a higher serum level.
Estetrol The therapeutic efficacy of Estetrol can be decreased when used in combination with Silver sulfadiazine.
Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen The therapeutic efficacy of Allogeneic cultured keratinocytes and dermal fibroblasts in murine collagen can be decreased when used in combination with Silver sulfadiazine.
Insulin human The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin human.
Insulin lispro The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin lispro.
Insulin glargine The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin glargine.
Insulin pork The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin pork.
Insulin aspart The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin aspart.
Insulin detemir The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin detemir.
Insulin glulisine The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin glulisine.
NN344 The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with NN344.
Insulin beef The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin beef.
Insulin degludec The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin degludec.
Insulin argine The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin argine.
Insulin peglispro The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin peglispro.
Insulin tregopil The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin tregopil.
Chloroprocaine The therapeutic efficacy of Silver sulfadiazine can be decreased when used in combination with Chloroprocaine.
Lidocaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Benzocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Quinisocaine.
Cisatracurium Silver sulfadiazine may increase the neuromuscular blocking activities of Cisatracurium.
Ambroxol The risk or severity of methemoglobinemia can be increased when Silver sulfadiazine is combined with Ambroxol.
Fecal microbiota The therapeutic efficacy of Fecal microbiota can be decreased when used in combination with Silver sulfadiazine.
Vibrio cholerae CVD 103-HgR strain live antigen The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Silver sulfadiazine.
Insulin icodec The risk or severity of hypoglycemia can be increased when Silver sulfadiazine is combined with Insulin icodec.

Target Protein

DNA
Dihydropteroate synthase folP

Referensi & Sumber

Synthesis reference: Charles L. Fox, Jr., Shanta M. Modak, Paul Fox, "Wound dressing comprising silver sulfadiazine incorporated in animal tissue and method of preparation." U.S. Patent US4599226, issued September, 1977.
Artikel (PubMed)
  • PMID: 15825409
    Fox CL Jr, Modak SM: Mechanism of silver sulfadiazine action on burn wound infections. Antimicrob Agents Chemother. 1974 Jun;5(6):582-8.
  • PMID: 8029478
    Russell AD, Hugo WB: Antimicrobial activity and action of silver. Prog Med Chem. 1994;31:351-70.
  • PMID: 15823649
    Percival SL, Bowler PG, Russell D: Bacterial resistance to silver in wound care. J Hosp Infect. 2005 May;60(1):1-7.

Contoh Produk & Brand

Produk: 80 • International brands: 3
Produk
  • Dermazin Crm 1%
    Cream • 1 % • Topical • Canada • Approved
  • Flamazine
    Cream • 1 % • Topical • Canada • Approved
  • Flamazine C
    Cream • - • Topical • Canada • Approved
  • Hydrogel AG Silver Antimicrobial Wound Dressing
    Gel • 1 kg/1kg • Topical • US • OTC
  • RayaSore Kit
    Kit • - • Topical • US
  • Silvadene
    Cream • 10 mg/1g • Topical • US • Approved
  • Silvadene
    Cream • 10 mg/1g • Topical • US • Approved
  • Silvadene
    Cream • 10 mg/1g • Topical • US • Approved
Menampilkan 8 dari 80 produk.
International Brands
  • Dermazin
  • Flamazine
  • Silverol

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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